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CCO Oncology Podcast

Clinical Care Options

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Updates on new data and best practices in the care of patients with cancer across a wide variety of solid tumors and hematologic malignancies from Clinical Care Options. Gain practical clinical insights and strategies and earn CME/CE credit for selected episodes.
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The EMJ Podcast is an educational podcast for healthcare professionals that covers the forefront of clinical practice, offering insights into the cutting edge of medicine. Through conversations with key opinion leaders, our host, physician and entrepreneur Jonathan Sackier, explores the latest trends and innovations, covering a number of clinical specialties, including oncology, dermatology, urology, cardiology, and many more.
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In this episode, host Jonathan Sackier is joined by Andrew Dunbar, Assistant Professor in the Department of Hematopoietic Biology and Malignancy at the University of Texas MD Anderson Cancer Center, Houston, USA. Dunbar discusses his research into myeloproliferative neoplasms, what drives disease progression and resistance, and promising targets fo…
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Tolaney focuses on advancing breast cancer treatment through innovative clinical research. She has been instrumental in developing novel therapies and leading key clinical trials, particularly for early-stage HER2-positive breast cancer.   Timestamps  00:09 – Introduction 01:12 – What is HER2-positive breast cancer? 03:00 – Key trials Tolaney has l…
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Stephanie Rutledge joins host Saranya Ravindran to unpack the mental health dimensions of alcohol use disorder. From co-occurring conditions and behavioural strategies like motivational interviewing to the role of family and community support, this episode explores how integrated care can strengthen recovery. Timestamps: 1:44 – Why hepatology 3:25 …
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In this rapid-fire episode, Stephanie Rutledge answers key questions on alcohol in hepatology, from mental health challenges in alcohol use disorder to transplant misconceptions, emerging therapies, and the impact of lifestyle changes like Dry January. It provides a concise, insightful overview in just minutes. Timestamps: 1:08 – Treating alcohol u…
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Listen in as Zev A. Wainberg, MD; Paul E. Oberstein, MD; and Mark O’Hara, MD, discuss the evolving treatment landscape for metastatic pancreatic cancer, including: How patients often present with disease-related symptoms Treatment selection considerations for the first-line and second-line setting How to approach palliative care discussions with pa…
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In this week's episode, we'll learn about how TET2 is often mutated in myeloid malignancies and clonal hematopoiesis. In new work, expansion of Tet2-mutant HSPCs was dependent on Ncoa4, the cargo receptor mediating ferritinophagy. We’ll iron out the implications. After that: a double-oh-seven license to kill in T-cell leukemia/lymphoma. WU-CART-007…
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This podcast and accompanying promotional content has been created in collaboration with and funded by  Biogen. This information is intended for healthcare professionals. The presented content includes mentions of the Skyclarys▼ (omaveloxolone) EU-approved label. Prescribing information for omaveloxolone can be found here. Friedreich's ataxia (FA) …
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In the final episode, Debby Bogaert discusses how cutting-edge microbiome science is being translated into practice. From novel vaccine approaches to strategies that support the developing microbiome, this conversation highlights how research can drive new preventive solutions to reduce pneumococcal disease and promote healthier lives for children …
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In part two, Debby Bogaert unpacks her pioneering research on the infant respiratory microbiome. Discover how early microbial communities in the airways influence immunity, infection risk, and long-term respiratory health — and why nurturing the microbiome could play a critical role in disease prevention. 0:38- Microbiome and Resilience Against Inf…
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In this episode, Dr Brad Kahl and Dr Noopur Raje discuss the recent advances and emerging data for CAR T-cell therapy in lymphomas and multiple myeloma including the latest evidence from long-term clinical trial follow-up and real-world data, plus new data with CAR T-cell therapies in new lymphoma settings and novel CAR T-cell therapies currently u…
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In this first deep dive, Debby Bogaert explores the global burden of pneumococcal disease in young children and compares its impact with RSV and flu. She discusses how pneumococcus colonises the respiratory tract, the role of co-infections, and the importance of vaccination. Listeners will also learn how early life factors and microbiome recovery s…
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Get to know Debby Bogaert in this fast-paced quickfire round. She shares the most overlooked aspect of pneumococcal disease, clears up common misconceptions, and reveals the biggest surprise from her research. From advice for new parents to public health leaders, this bite-sized episode is packed with insights Timestamps: 2:14- Overlooked aspect of…
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In this week's episode we'll learn about targeting NPM1 in acute myeloid leukemia. Researchers report the first clinical evidence of a menin inhibitor inducing complete remissions in AML with a NPM1 mutation. This validates NPM1 as a new therapeutic target in AML, alongside FLT3, IDH1/2, and KMT2A. Also on the podcast: targeting CD137 to prevent gr…
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Blood Editor, Dr. Thomas Coates interviews Dr. Emanuele Angelucci on his paper, "How I manage iron overload in the hematopoietic cell transplantation setting" which is featured in Blood's "How I Treat Series on Iron Overload in Hematologic Disorders". See the full How I Treat series in volume 145 issue 4 of Blood.…
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In this episode, host Saranya Ravindran is joined by Toby Maher to explore the often-overlooked world of interstitial lung diseases. From clarifying common misconceptions to highlighting AI innovations and personalised treatments, the series dives deep into what clinicians need to know about these serious lung conditions. Whether you're new to inte…
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In this episode, host Saranya Ravindran is joined by Toby Maher to explore the often-overlooked world of interstitial lung diseases. From clarifying common misconceptions to highlighting AI innovations and personalised treatments, the series dives deep into what clinicians need to know about these serious lung conditions. Whether you're new to inte…
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In this episode, Drs William J. Gradishar, Heather McArthur, and Joanne Mortimer address audience questions from a recent live event on the use of CDK4/6 inhibitors in patients with early and metastatic breast cancer, including: Genomic testing options for assessing risk of recurrence Adjuvant treatment duration and holidays with CDK4/6 inhibitors …
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In this episode, host Saranya Ravindran is joined by Toby Maher to explore the often-overlooked world of interstitial lung diseases. From clarifying common misconceptions to highlighting AI innovations and personalised treatments, the series dives deep into what clinicians need to know about these serious lung conditions. Whether you're new to inte…
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In this episode, host Saranya Ravindran is joined by Toby Maher to explore the often-overlooked world of interstitial lung diseases. From clarifying common misconceptions to highlighting AI innovations and personalised treatments, the series dives deep into what clinicians need to know about these serious lung conditions. Whether you're new to inte…
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In this episode of Onc Now, host Jonathan Sackier welcomes Komal Jhaveri, Breast Medical Oncologist and clinical investigator at Memorial Sloan Kettering Cancer Center, New York, USA. Known for her trailblazing work in HER2-positive, HER2-low, and hormone receptor-positive breast cancers, Komal Jhaveri discusses how molecular subtyping, antibody-dr…
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In this week's episode we'll learn about how by combining PET response with circulating tumor DNA, or ctDNA, in newly treated patients with follicular lymphoma, investigators identify those patients likely to progress within 24 months of initial treatment, also known as POD24. After that: Immune hotspots in aplastic anemia. These newly identified h…
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In the final episode of this series on preventative medicine, Vinod Patel discusses how integrated care models, professional training, and patient education improve diabetes outcomes. From chronic fatigue clinics to national screening programs, this episode highlights how innovation in education and collaboration can transform diabetes care across …
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What do retinal scans reveal about diabetes complications? In Part 2, Vinod Patel shares insights from his clinical research on diabetic retinopathy, including key risk factors, the impact of hypertension, and the future of screening using advanced imaging tools. A must-listen for clinicians and anyone curious about the eyes-diabetes connection. Ti…
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In this week's episode, we’ll learn more about how exogenous CD19 stimulation affects CAR T-cell persistence in B-cell acute lymphoblastic leukemia treated with CD19 CAR T-cell therapy; new algorithms that incorporate sequential rapid immune-assays, intended to improve diagnosis of heparin-induced thrombocytopenia, and resource-adaptive survival pr…
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Vinod Patel joins host Catherine Glass to explore how technology, early intervention, and integrated care are changing diabetes prevention. Learn about the ‘Alphabet Strategy’, machine learning in postpartum prediabetes prediction, and the growing role of glucagon-like peptide-1 (GLP-1) injectables. This episode unpacks how we can identify and redu…
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In this episode, Dr. Daniel Morgensztern and Dr. Jonathan Strosberg discuss the emerging role of DLL3-targeted agents in the management of extrapulmonary neuroendocrine carcinomas, including: The clinical implications of using DLL3 as a therapeutic target The impact of emerging DLL3-targeted therapies on evolving treatment paradigms How to incorpor…
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In this episode, host Jonathan Sackier is joined by Emanuele Angelucci, Director of Hematology and Cellular Therapies and Director of the Stem Cell Transplant and Cellular Therapies Program at the Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Ospedale Policlinico San Martino Hospital in Genoa, Italy. Timestamps  00:00 – Introduction …
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In this episode, listen to Kelly Romo, PharmD, BCOP; and Shauna Kraft, PharmD, BCOP, share their takeaways from a live webinar on available emerging subcutaneous immunotherapy options for patients with cancer including: Basic mechanism of action and role of hyaluronidase in subcutaneous immunotherapy formulation and available dosing/schedules Avail…
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In this deeply personal episode, Jonathan Sackier speaks with Zoe Strickland, author of To Grief With Love, about how she navigated the loss of her son and found space for healing through creative expression and connection. They reflect on the evolving nature of grief, the importance of making space for sadness, and the small but powerful ways we c…
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In this week's episode, we’ll learn more about the effects of daratumumab maintenance on minimal residual disease in patients with newly diagnosed, transplant-eligible multiple myeloma; the role of neutrophils in the pathophysiology of myeloproliferative neoplasms; and a genome-wide association study that identified novel genetic loci associated wi…
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In this series, host Catherine Glass speaks with David Cosio about  the complex and often overlooked relationship between anxiety and chronic pain. They explore the neurobiological underpinnings of both conditions, how they influence each other, and what the future of integrated pain management may look like, from AI to psychedelics and beyond. 0:4…
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In this episode, host Catherine Glass speaks with David Cosio about  the complex and often overlooked relationship between anxiety and chronic pain. They explore the neurobiological underpinnings of both conditions, how they influence each other, and what the future of integrated pain management may look like, from AI to psychedelics and beyond.…
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In this episode of Onc Now, host Jonathan Sackier is joined by Simon Lord, Associate Professor in Experimental Cancer Therapeutics, University of Oxford, UK, to discuss translating scientific breakthroughs into real-world treatments. With deep expertise in precision medicine and a passion for innovation in oncology, Lord brings a unique perspective…
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In this series, host Catherine Glass speaks with David Cosio about  the complex and often overlooked relationship between anxiety and chronic pain. They explore the neurobiological underpinnings of both conditions, how they influence each other, and what the future of integrated pain management may look like, from AI to psychedelics and beyond. Tim…
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In this series, host Catherine Glass speaks with David Cosio about  the complex and often overlooked relationship between anxiety and chronic pain. They explore the neurobiological underpinnings of both conditions, how they influence each other, and what the future of integrated pain management may look like, from AI to psychedelics and beyond.…
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In this week's episode we'll learn more about enhanced transplant characteristics; targeting the JAK-STAT pathway with ruxolitinib in patients with adult-onset Still’s disease and macrophage activation syndrome; and a pair of trials demonstrating lack of benefit for the anti-CD47 monoclonal antibody magrolimab in newly diagnosed acute myeloid leuke…
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In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and wha…
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In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and wha…
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In this episode of Onc Now, host Jonathan Sackier is joined by Stephen Freedland, Surgical Oncologist at Cedars-Sinai Medical Center, Los Angeles, California, USA, to discuss the intersections of biology, behaviour, and bias in prostate cancer. From diet and exercise to disparities in outcomes and promising data on enzalutamide, Freedland challenge…
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In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and wha…
  continue reading
 
In the second episode of our Rare Lung Diseases podcast mini-series, host Saranya Ravindran delves into the complexities of pulmonary arterial hypertension (PAH) with Neal Chaisson, Assistant Professor of Medicine at the Cleveland Clinic. Chaisson shares insights into why PAH remains under-recognised, the nuances of detection and diagnosis, and wha…
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In this podcast, Max S. Topp, MD, and Pier Luigi Zinzani, MD, PhD, explore the current and future implications of some of their top choices of studies in lymphomas and ALL presented at the EHA and ICML 2025 meetings. Program Abstracts: POLARGO: Rituximab, Gemcitabine and Oxaliplatin ± Polatuzumab Vedotin for R/R DLBCL ECHO: Rituximab-Bendamustine ±…
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In this episode, Kevin Kalinsky, MD, MS, FASCO, and Sara M. Tolaney, MD, MPH, discuss the most clinically relevant data in breast cancer presented at the 2025 ASCO Annual Meeting, including: DESTINY-Breast09: phase III trial of trastuzumab deruxtecan with or without pertuzumab vs THP as first-line treatment of HER2-positive advanced/metastatic brea…
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In this episode, listen to Laura M. Spring, MD; and Shipra Gandhi, MD, MS, share their takeaways from a large educational program on available and emerging first-line treatment options for patients with HER2-positive mBC: Emerging new data from the phase IIII DESTINY-Breast09 trial of first-line treatment with trastuzumab deruxtecan ± pertuzumab vs…
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In this episode, Eunice Wang, MD and Eytan Stein, MD explore the latest key clinical updates on menin inhibitors in AML. This episode unpacks evolving treatment strategies and what these developments mean for patient care. Presenters: Eytan M. Stein, MD Chief, Leukemia Service Director, Program for Drug Development in Leukemia Associate Attending P…
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In this week's episode, we'll learn about a JAK inhibitor to prevent complications of CD19-directed CAR T-cell therapy. In a phase 2 study, itacitinib was well tolerated and demonstrated promising reductions in the incidence of cytokine release syndrome and neurotoxicity. After that: investigators report direct interactions between ChAdOx1 and plat…
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