Best Multiethnic Podcasts (2025)

1
184: High-Accuracy Multiethnic XGBoost for Skin Cancer Identification 17:44

Play Pause

8d ago17:44

17:44

️ Episode 184: High-Accuracy Multiethnic XGBoost for Skin Cancer Identification In this episode of PaperCast Base by Base, we explore a large-scale study that builds a risk factor–based XGBoost model using the All of Us cohort to accurately identify patients with skin cancer across diverse ancestries. Study Highlights: Analyzing more than 400,000 p…

1
191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI 19:17

1d ago19:17

19:17

️ Episode 191: CATphishing: Synthetic Learning as an Alternative to Federated Learning in MRI In this episode of PaperCast Base by Base, we explore a Nature Communications study that proposes CATphishing—an approach that uses latent diffusion models to generate site-specific synthetic 3D brain MRIs for collaborative training without sharing raw dat…

1
190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes 15:43

3d ago15:43

15:43

️ Episode 190: Single-Cell Networks Reveal Cell Type–Specific Mechanisms in Type 2 Diabetes In this episode of PaperCast Base by Base, we explore how a network-based analysis of single-cell RNA sequencing from human pancreatic islets uncovers cell type–specific gene-regulatory changes that help explain type 2 diabetes pathophysiology. Study Highlig…

1
189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms 14:22

4d ago14:22

14:22

️ Episode 189: DNA methylation patterns facilitate tracing the origin of neuroendocrine neoplasms In this episode of PaperCast Base by Base, we explore how genome-wide DNA methylation profiling can pinpoint the organ of origin for neuroendocrine neoplasms (NEN), with a special focus on lesions detected in the liver and long-debated “primary hepatic…

1
The In-Between Sky with Alison Hart 58:39

2d ago58:39

58:39

This week on Militantly Mixed I’m joined by the brilliant Alison Hart, an OG Mixed Cousin who first appeared on Episode 24 back in 2018 with the release of her debut novel, Mostly White. Alison returns to share her stunning new novel, The In-between Sky, and we dive into creativity, identity, and what it means to write from a Mixed-race perspective…

1
188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis 16:51

5d ago16:51

16:51

️ Episode 188: Proteomics + Machine Learning for Lyme Neuroborreliosis Diagnosis In this episode of PaperCast Base by Base, we explore how large‑scale mass‑spectrometry proteomics of cerebrospinal fluid and plasma, paired with supervised machine learning, can distinguish Lyme neuroborreliosis from viral meningitis and non‑LNB controls in adults. St…

1
187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors 16:13

6d ago16:13

16:13

️ Episode 187: Gapped PARP + Tumor‑Targeted TOP1 in Advanced Tumors In this episode of PaperCast Base by Base, we explore a phase I dose‑escalation trial that pairs a tumor‑targeted topoisomerase I inhibitor (CRLX101, a nanoparticle camptothecin) with optimized, gapped scheduling of the PARP inhibitor olaparib to reduce toxicity while preserving ef…

1
186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome 15:22

7d ago15:22

15:22

️ Episode 186: TNFα–TGFβ Axis Disrupts Nasal Epithelium in Post‑COVID Syndrome In this episode of PaperCast Base by Base, we explore a single‑cell RNA‑seq study of nasal biopsies showing that persistent immune signaling—not residual virus—drives aberrant epithelial differentiation in people with post‑COVID syndrome. fileciteturn1file0 Study High…

1
Don't Let Go 34:59

7d ago34:59

34:59

Are you tired, overwhelmed, or wondering if you can keep holding on to your faith? King Hezekiah's story reminds us what's possible when we refuse to let go of God. In 2 Kings 18, we meet Hezekiah—a king who "clung to the Lord" and didn't depart from following Him. Unlike other kings who did right "but" left compromises in place, Hezekiah went all …

1
185: Altered Milk Tryptophan in Women Living with HIV 14:59

7d ago14:59

14:59

️ Episode 185: Altered Milk Tryptophan in Women Living with HIV In this episode of PaperCast Base by Base, we explore a longitudinal metabolomics study of human milk that reveals how maternal HIV infection reshapes tryptophan metabolism across lactation, with potential implications for infant immunity, growth, and neurodevelopment. Study Highlights…

1
183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences 18:05

10d ago18:05

18:05

️ Episode 183: The Genetic Lottery Goes to School: Better Schools Compensate for Genetic Differences In this episode of PaperCast Base by Base, we explore a large causal study from Norway asking whether school quality can offset genetic differences in students’ academic skills. Using parent–offspring genetic trios from the Norwegian Mother, Father,…

1
182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome 16:18

11d ago16:18

16:18

️ Episode 182: Genotypic, Functional, and Phenotypic Characterization in CTNNB1 Neurodevelopmental Syndrome In this episode of PaperCast Base by Base, we explore a large cross-sectional cohort study that integrates genetics, cellular functional assays, and deep phenotyping to map the landscape of CTNNB1 neurodevelopmental syndrome. The authors anal…

1
181: Creatine Transporter SLC6A8: Conservation and Variant Impact 12:44

11d ago12:44

12:44

️ Episode 181: Creatine Transporter SLC6A8: Conservation and Variant Impact In this episode of PaperCast Base by Base, we explore how the creatine transporter gene SLC6A8 (CRT1) is evolutionarily conserved across terrestrial mammals and how disease-associated variants alter creatine uptake in vitro, shedding light on genotype–phenotype relationship…

1
Militantly Mixed: Quick Update — Transition Pains & Platform Changes 11:10

9d ago11:10

11:10

Even though Militantly Mixed is still on Mental Health hiatus, I wanted to drop a quick update for my Mixed Cousins about a few important tech transitions because of technical difficulties. First, I recently switched the email domain, and some of you may be getting spam, spoofing, or phishing warnings when you receive emails from me. I’m working on…

1
180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction 22:11

13d ago22:11

22:11

️ Episode 180: Leveraging Global Genetics Resources for Equitable Polygenic Prediction In this episode of PaperCast Base by Base, we explore how multi-ancestry genome-wide association study resources and modern polygenic score methodologies can improve prediction accuracy across African, East Asian, and European populations, with a focus on practic…

1
Stay Humble 41:21

14d ago41:21

41:21

Ever wonder how someone doing everything right can still lose their way? King Uzziah started strong—16 years old, reigning 52 years, blessed by God with military victories and prosperity. But somewhere along the way, pride crept in. This sermon from our "Crowned But Compromised" series walks through the sobering story of King Uzziah (also called Az…

1
179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases 16:49

14d ago16:49

16:49

️ Episode 179: Mosaicism for Autosomal Trisomies: Maternal Age, UPD, and Reproductive History in 1,266 Cases In this episode of PaperCast Base by Base, we explore a comprehensive literature analysis of 1,266 reported cases of autosomal trisomy mosaicism, contrasting prenatal cohorts—true fetal mosaicism and confined placental mosaicism—with postnat…

1
178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications 15:59

14d ago15:59

15:59

️ Episode 178: TP53 Reduced Penetrance: Predictive Features and Clinical Implications In this episode of PaperCast Base by Base, we explore how a large ClinVar-anchored analysis integrates functional assays, computational predictors, immunogenicity estimates, allele frequencies, and clinical presentation to identify TP53 variants with reduced penet…

1
177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition 17:04

15d ago17:04

17:04

️ Episode 177: Biallelic MCM8/MCM9 Variants: From Hypogonadism to Cancer Predisposition In this episode of PaperCast Base by Base, we explore a multi‑cohort clinical–genomic study that delineates the phenotype of individuals with biallelic germline variants in MCM8 or MCM9, clarifying links to polyposis and early‑onset cancers in addition to the lo…

1
176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma 19:32

16d ago19:32

19:32

️ Episode 176: FAHD1 and the Pyruvate-Driven Evolution of Hepatocellular Carcinoma In this episode of PaperCast Base by Base, we explore how multi-omics integration—spanning single-cell transcriptomics, spatial mapping, and causal genetic inference—uncovers a pyruvate-hyperactive epithelial subpopulation in hepatocellular carcinoma and identifies F…

1
175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk 19:13

17d ago19:13

19:13

️ Episode 175: Predictive Prioritization of Pancreatic Enhancers Linked to Disease Risk In this episode of PaperCast Base by Base, we explore how enhancer–promoter 3D chromatin maps from five primary human pancreatic cell types were transformed into graph “tree” models to quantify enhancer connectivity and prioritize elements most critical for cell…

1
174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility 16:40

18d ago16:40

16:40

️ Episode 174: TMEM217–SLC9C1: Wiring the cAMP Switch for Sperm Motility and Male Fertility In this episode of PaperCast Base by Base, we explore a PNAS study revealing how TMEM217 forms a complex with the sperm-specific Na+/H+ exchanger SLC9C1 to organize cAMP signaling, sustain motility, and enable fertilization in mice. Study Highlights: Using p…

1
Disarm - the Animated Short Film 48:14

17d ago48:14

48:14

In this episode of Militantly Mixed, Sharmane sits down with the creative team behind Disarm, an animated short film that captures the painful yet powerful intersections of identity, grief, and resilience in the wake of anti-Asian violence. Following the 2021 Atlanta spa shootings, Disarm tells the story of a young woman navigating multiple layers …

1
173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset 20:12

20d ago20:12

20:12

️ Episode 173: Bottlebrush Block Copolymer Shields Muscles and Prevents DMD Onset In this episode of PaperCast Base by Base, we explore a PNAS study showing how a synthetic bottlebrush block copolymer can act as a powerful membrane stabilizer to protect dystrophin-deficient muscle in Duchenne muscular dystrophy. Study Highlights: Researchers engine…

1
172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense 19:44

20d ago19:44

19:44

️ Episode 172: When Random DNA Fights Back: De Novo Gene Birth as Antiphage Defense In this episode of PaperCast Base by Base, we explore a PNAS study showing that short, previously nongenic DNA sequences can quickly evolve into genes that help bacteria survive phage attack, illuminating early steps of gene birth and the host–virus arms race. file…

1
Who Are You? 40:53

21d ago40:53

40:53

When everything you've relied on shifts—when the voices that guided you are gone—who will you become? Kylie unpacks the story of King Joash, a boy hidden in God's temple who grew up to be king. Raised by a faithful priest, Joash restored the temple and honored God—but only while his mentor was alive. When that voice disappeared, Joash listened to d…

1
171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? 16:14

22d ago16:14

16:14

️ Episode 171: Virulence Hierarchies in the Tuberculosis Complex—What Makes Some Lineages Deadlier? In this episode of PaperCast Base by Base, we explore a new PNAS study that directly compares the virulence of Mycobacterium tuberculosis, M. bovis, and M. orygis across natural and laboratory hosts to uncover why animal-adapted lineages can be so de…

1
170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans 17:03

23d ago17:03

17:03

️ Episode 170: Maternal Age, Meiotic Recombination Failure, and Triploidy in Humans In this episode of PaperCast Base by Base, we explore how maternal age and failures of meiotic recombination shape the origins of triploid conceptions in humans, drawing on large-scale preimplantation genetic testing datasets from ICSI-derived embryos. Study Highlig…

1
169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance 21:13

23d ago21:13

21:13

️ Episode 169: Deep mutational scanning of the insulin receptor guides precision therapy for insulin resistance In this episode of PaperCast Base by Base, we explore how a comprehensive deep mutational scan of the human insulin receptor ectodomain maps the effects of ~14,000 missense variants on surface expression, insulin binding, and downstream s…

1
168: Low circulating miR-190a-5p predicts progression of chronic kidney disease 19:10

25d ago19:10

19:10

️ Episode 168: Low circulating miR-190a-5p predicts progression of chronic kidney disease In this episode of PaperCast Base by Base, we explore how unbiased small RNA sequencing and multi-cohort validation identify circulating miR-190a-5p as a prognostic marker of chronic kidney disease that reflects tubular health and points to a potential therape…

1
167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution 21:40

25d ago21:40

21:40

️ Episode 167: DeepScence: Detecting Senescent Cells at Single-Cell and Spatial Resolution In this episode of PaperCast Base by Base, we explore a Cell Genomics study introducing DeepScence, a deep-learning autoencoder that leverages a compact “CoreScence” gene set to identify senescent cells across single-cell and spatial transcriptomics data, out…

1
What are You Making Peace With? 39:11

27d ago39:11

39:11

Are you keeping the peace in areas where God is calling you to stand out? King Jehoshaphat loved God and did what was right—but he made one compromise that changed everything. He made peace with King Ahab, one of the most wicked kings in Israel's history. This alliance almost cost him his life and opened the door for rebellion in the next generatio…

1
166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments 13:37

27d ago13:37

13:37

️ Episode 166: Molecular Squeezing: How Coronin, Cofilin, and AIP1 Rapidly Disassemble Actin Filaments In this episode of PaperCast Base by Base, we explore a Cell study that uses single-particle cryo-EM to reveal the stepwise, synergistic mechanism by which coronin, cofilin, and AIP1 drive rapid actin filament disassembly in eukaryotic cells. Stud…

1
165: Protist Genomics: Key to Understanding Eukaryotic Evolution 19:24

28d ago19:24

19:24

️ Episode 165: Protist Genomics: Key to Understanding Eukaryotic Evolution In this episode of PaperCast Base by Base, we explore how accelerating protist genomics—spanning single-cell approaches, metagenomics, and long-read assemblies—unlocks deep insights into eukaryotic evolution, symbiosis, organelle origins, ecosystem dynamics, and the methodol…

1
164: m6A in the coding sequence: linking deposition, translation, and decay 14:46

29d ago14:46

14:46

️ Episode 164: m6A in the coding sequence: linking deposition, translation, and decay In this episode of PaperCast Base by Base, we explore how N6-methyladenosine (m6A) marks within coding sequences orchestrate a fast, translation-coupled route to mRNA decay, and how splicing- and chromatin-linked mechanisms shape where those marks are placed acros…

1
163: Animal origins: looping back in time 14:18

30d ago14:18

14:18

️ Episode 163: Animal origins: looping back in time In this episode of PaperCast Base by Base, we explore how chromatin folding mechanisms emerged alongside animal evolution, focusing on a Spotlight article that synthesizes high-resolution 3D genome maps across unicellular relatives of animals and early-branching metazoans to probe when enhancer–pr…

1
162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities 20:15

1M ago20:15

20:15

️ Episode 162: Spatially Resolved microRNA Expression in Tissues: Technologies, Challenges, and Opportunities In this episode of PaperCast Base by Base, we explore how emerging “spatial miRNomics” methods map microRNA expression directly within intact tissues, revealing cell- and region-specific regulatory patterns that bulk and even single-cell as…

1
161: Decoding Genomic Landscapes of Introgression 20:55

1M ago20:55

20:55

️ Episode 161: Decoding Genomic Landscapes of Introgression In this episode of PaperCast Base by Base, we explore how modern population genetics dissects the genomic footprints of introgression across species, reviewing summary statistic approaches, probabilistic modeling, and supervised learning, and showing how these methods reveal adaptive and g…

1
160: The Long‑Read Leap in Single‑Cell Omics 15:36

1M ago15:36

15:36

By Gustavo Barra

1
159: The Untapped Potential of Short‑Read Sequencing in Biodiversity Research 15:56

1M ago15:56

15:56

️ Episode 159: The Untapped Potential of Short‑Read Sequencing in Biodiversity Research In this episode of PaperCast Base by Base, we explore how modern short‑read sequencing and genome skimming are reshaping biodiversity science—from rapid species identification and biomass estimation to scalable phylogenomics and holobiont studies—while keeping c…

1
158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost? 22:35

1M ago22:35

22:35

️ Episode 158: Interruptions in Repeat Expansion Diseases: How Are They Gained and Lost? In this episode of PaperCast Base by Base, we explore how small sequence changes—“interruptions”—within expanded tandem repeats shape the onset and severity of repeat expansion disorders, and a new mechanistic model that may explain how these interruptions are …

1
Dont Forget The High Places 38:30

1M ago38:30

38:30

By Dr. Brian Taylor

1
157: Synthetic gametes and the non-identity problem: the babies of tomorrow 14:32

1M ago14:32

14:32

️ Episode 157: Synthetic gametes and the non-identity problem: the babies of tomorrow In this episode of PaperCast Base by Base, we explore how synthetic DNA technologies may enable the creation of synthetic gametes and why this possibility forces a rethinking of identity, harm, and responsibility in human reproduction. Study Highlights: The author…

1
156: RAEFISH: Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution 17:07

1M ago17:07

17:07

️ Episode 156: RAEFISH: Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution In this episode of PaperCast Base by Base, we explore RAEFISH, a reverse-padlock amplicon-encoding FISH method that delivers whole-transcriptome imaging at single-molecule resolution without sequencing. The study demonstrates genome-scale cove…

1
155: EIF3A/EIF3B Loss-of-Function: A Cardiocraniofacial Neurodevelopmental Syndrome 15:53

1M ago15:53

15:53

️ Episode 155: EIF3A/EIF3B Loss-of-Function: A Cardiocraniofacial Neurodevelopmental Syndrome In this episode of PaperCast Base by Base, we explore how loss-of-function variants in EIF3A and EIF3B—core components of the eIF3 translation initiation complex—cause a multisystem disorder marked by congenital heart defects, craniofacial differences, and…

1
154: Multiple-testing corrections in selection scans using identity-by-descent segments 20:05

1M ago20:05

20:05

️ Episode 154: Multiple-testing corrections in selection scans using identity-by-descent segments In this episode of PaperCast Base by Base, we explore how Temple and Browning develop principled genome-wide significance thresholds for IBD-based scans of recent positive selection by explicitly modeling correlation along the genome. Study Highlights:…

1
153: Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits 15:13

1M ago15:13

15:13

️ Episode 153: Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits In this episode of PaperCast Base by Base, we explore a large skeletal muscle eQTL meta-analysis that integrates GTEx and FUSION data to pinpoint regulatory variants and genes underlying muscular and cardiometabolic …

1
152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia 16:53

1M ago16:53

16:53

️ Episode 152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia In this episode of PaperCast Base by Base, we explore a validated single‑well multiplex digital droplet PCR (ddPCR) assay that reconstructs the TPSAB1 locus by quantifying α‑ and β‑tryptase copy numbers to diagnose hereditary alpha tryptasemia (HαT) in symptomatic patients. St…

1
151: EQA of ctDNA Mutation Testing Across the COIN Consortium 16:21

1M ago16:21

16:21

️ Episode 151: EQA of ctDNA Mutation Testing Across the COIN Consortium In this episode of PaperCast Base by Base, we explore how 16 Dutch laboratories evaluated their real‑world workflows for circulating tumor DNA (ctDNA) mutation testing across BRAF, EGFR, and KRAS using a coordinated external quality assessment within the COIN consortium. Study …

1
A Generous People 41:09

1M ago41:09

41:09

By Dr. Brian Taylor