Best Model Fine Tuning Podcasts (2025)

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How OpenAI Builds for 800 Million Weekly Users: Model Specialization and Fine-Tuning 53:24

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21d ago53:24

53:24

In this episode, a16z GP Martin Casado sits down with Sherwin Wu, Head of Engineering for the OpenAI Platform, to break down how OpenAI organizes its platform across models, pricing, and infrastructure, and how it is shifting from a single general-purpose model to a portfolio of specialized systems, custom fine-tuning options, and node-based agent …

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Do Revenue and Margins Still Matter in AI? 1:02:30

20h ago1:02:30

1:02:30

In this episode, we’re sharing a conversation with David George, General Partner at a16z on the firm’s growth investing team. David has been involved in backing many of the defining companies of this era and is now investing behind a new wave of AI startups. This discussion goes deep into how the a16z growth practice operates: how the team hires an…

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The Crime Crisis In America and How Technology Fixes It 59:30

1d ago59:30

59:30

What if America tried to eliminate crime instead of just reacting to it? Not with slogans, but with staffing, technology, and strategy scaled to the problem. In this episode, Erik Torenberg speaks with Garrett Langley, founder and CEO of Flock Safety, and Ben Horowitz, cofounder of a16z, about what is happening in the cities that are trying. Flock …

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Ryo Lu (Cursor): AI Turns Designers to Developers 52:01

3d ago52:01

52:01

Ryo Lu spent years watching his designs die in meetings. Then he discovered the tool that lets designers ship code at the speed of thought: Cursor, the company where Ryo is now Head of Design. In this episode, a16z General Partner Jennifer Li sits down with Ryo to discuss why "taste" is the wrong framework for understanding the future, why purposef…

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AMA | December 2025 3:36:43

4d ago3:36:43

3:36:43

Welcome to the December 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the que…

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AI Eats the World: Benedict Evans on the Next Platform Shift 1:02:50

6d ago1:02:50

1:02:50

AI is reshaping the tech landscape, but a big question remains: is this just another platform shift, or something closer to electricity or computing in scale and impact? Some industries may be transformed. Others may barely feel it. Tech giants are racing to reorient their strategies, yet most people still struggle to find an everyday use case. Tha…

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Episode 5: How Anthropic Engineers use AI, Spec Driven Development, and LLM Psychological Profiles 57:02

7d ago57:02

57:02

In this episode, Shimin and Dan explore the evolving landscape of AI in software engineering, discussing the implications of the Cloud Opus 4.5 sole document, the ethical considerations of AI models, and the impact of AI on developer productivity. They delve into spec-driven development, the latest advancements in AI models like DeepSeek v3.2, and …

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Quantum Fluctuations: Did Random Energy Spark the Entire Universe? 27:56

1h ago27:56

27:56

https://www.theforbiddenknowledgenetwork.com Could the entire cosmos have emerged from nothing? According to leading theories in quantum physics, random fluctuations in the vacuum of space may have triggered the Big Bang—producing time, matter, and the laws of physics from an unstable sea of energy. But if our universe was born from a quantum event…

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How the Best CEOs Delegate 57:34

8d ago57:34

57:34

Jonathan Swanson has built two rare successes: Thumbtack, the home-services marketplace, and Athena, the fast-growing platform that pairs ambitious people with world-class personal assistants. Today he runs a 4,000-person company, invests on the side, and raises four kids — all by designing his life around leverage. a16z General Partner, Erik Toren…

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The $3 Trillion AI Coding Opportunity 37:59

10d ago37:59

37:59

Originally published on the a16z Infra podcast. We're resurfacing it here for our main feed audience. AI coding is already actively changing how software gets built. a16z Infra Partners Yoko Li and Guido Appenzeller break down how "agents with environments" are changing the dev loop; why repos and PRs may need new abstractions; and where ROI is sho…

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The 80-Year Bet: Why Naveen Rao Is Rebuilding the Computer from Scratch 30:11

10d ago30:11

30:11

Naveen Rao is cofounder and CEO of Unconventional AI, an AI chip startup building analog computing systems designed specifically for intelligence. Previously, Naveen led AI at Databricks and founded two successful companies: Mosaic (cloud computing) and Nervana (AI accelerators, acquired by Intel). In this episode, a16z’s Matt Bornstein sits down w…

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338 | Ryan Patterson on the Physics of Neutrinos 1:26:21

11d ago1:26:21

1:26:21

The story goes that Wolfgang Pauli, who first proposed the existence of neutrinos, was embarrassed to have done so, as it was considered uncouth to hypothesize new particles that could not be detected. Modern physicists have no such scruples, of course, but more importantly neutrinos turn out to be very detectable, given sufficient resources and ex…

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Episode 4: Open AI Code Red, TPU vs GPU and More Autonomous Coding Agents 1:04:22

14d ago1:04:22

1:04:22

In this episode of Artificial Developer Intelligence, hosts Shimin and Dan discuss the evolving landscape of AI in software engineering, touching on topics such as OpenAI's recent challenges, the significance of Google TPUs, and effective techniques for working with large language models. They also delve into a deep dive on general agentic memory, …

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What Comes After ChatGPT? The Mother of ImageNet Predicts The Future 1:01:56

14d ago1:01:56

1:01:56

Fei-Fei Li is a Stanford professor, co-director of Stanford Institute for Human-Centered Artificial Intelligence, and co-founder of World Labs. She created ImageNet, the dataset that sparked the deep learning revolution. Justin Johnson is her former PhD student, ex-professor at Michigan, ex-Meta researcher, and now co-founder of World Labs. Togethe…

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#750: re:Invent 2025 - Day 3 Wrapup 22:42

5d ago22:42

22:42

It is the end of re:Invent! Simon and Jillian share some updates and also take a moment to reflect on 2025.By Amazon Web Services

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How AI Created the Fastest Product Cycle in History 50:54

15d ago50:54

50:54

Recently, a16z General Partner Anish Acharya joined Ollie Forsyth on NEW ECONOMIES. They talked about why consumer tech is surging again, how AI is enabling 100M-user products at unprecedented speed, and what founders need to understand heading into 2026 — from distribution shifts to founder mindset to the mechanics behind the fastest product cycle…

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#749: re:Invent 2025 - Swami Sivasubramanian Keynote 27:07

9d ago27:07

27:07

Simon and Jillian catch you up on the highlights from today's keynote PLUS all the "pre:Invent" announcements that took place prior to the event!By Amazon Web Services

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Why AI Moats Still Matter (And How They've Changed) 51:31

16d ago51:31

51:31

a16z General Partners David Haber, Alex Rampell, and Erik Torenberg discuss why 19 out of 20 AI startups building the same thing will die - and why the survivor might charge $20,000 for what used to cost $20. They expose the "janitorial services paradox" (why the most boring software is most defensible), explain why OpenAI won't compete with your o…

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#748: re:Invent 2025 - Matt Garman Keynote 39:14

2d ago39:14

39:14

In this episode, Matt Garman's 2025 re:Invent keynote unveils exciting AI advancements, including Amazon Nova to Lite, a cost-effective reasoning model, and Amazon Nova 2 Sonic, a new speech-to-text model. The keynote also covers Security, Storage, Compute, Networking, and a whole lot more!By Amazon Web Services

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How To Lead | Ben Horowitz on My First Million 1:10:40

17d ago1:10:40

1:10:40

A16Z co-founder Ben Horowitz joins Shaan Puri and Sam Parr on My First Million to talk about how to be a great leader. Resources: Follow Ben on X: https://x.com/bhorowitz Follow Shaan on X: https://x.com/ShaanVP Follow Sam on X: https://x.com/thesamparr Stay Updated: If you enjoyed this episode, be sure to like, subscribe, and share with your frien…

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337 | Kevin Zollman on Game Theory, Signals, and Meaning 1:17:37

18d ago1:17:37

1:17:37

Game theory is a way of quantitatively describing what happens any time one thing interacts with another thing, when both things have goals and potential rewards. That's a pretty broad class of interesting events, so it is unsurprising that game theory is a useful way of thinking about everything from international relations to the evolution of pea…

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The $700 Billion AI Productivity Problem No One's Talking About 58:17

18d ago58:17

58:17

Russ Fradin sold his first company for $300M. He’s back in the arena with Larridin, helping companies measure just how successful their AI actually is. In this episode, Russ sits down with a16z General Partner Alex Rampell to reveal why the measurement infrastructure that unlocked internet advertising's trillion-dollar boom is exactly what's missin…

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Claude Opus 4.5, Olmo 3, and a Paper on Diffusion + Auto Regression 47:45

20d ago47:45

47:45

In this episode of Artificial Developer Intelligence, hosts Shimin and Dan explore the latest advancements in AI models, including the release of Claude Opus 4.5 and Gemini 3. They discuss the implications of these models on software engineering, the rise of open-source models like Olmo 3, and the enhancements in the Claude Developer Platform. The …

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It's Gemini 3 Week! And How to Persuade an LLM to Call You a Jerk 58:49

20d ago58:49

58:49

In this episode of Artificial Developer Intelligence, hosts Shimin and Dan explore the latest developments in AI, including Google's Gemini 3 model and its implications for software engineering. They discuss the rise of AI-driven cybersecurity threats, the concept of world models, and the evolving landscape of software development techniques. The c…

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AI Benchmarks, Tech Radar, and Limits of Current LLM Architectures 51:49

20d ago51:49

51:49

In this episode of Artificial Developer Intelligence, hosts Shimin and Dan explore the rapidly evolving landscape of AI, discussing recent news, benchmarking challenges, and the implications of AGI as a conspiracy theory. They delve into the latest techniques in AI development, ethical considerations, and the potential impact of AI on human intelli…

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Ben Horowitz: Why Open Source AI Will Determine America's Future 46:50

22d ago46:50

46:50

Ben Horowitz reveals why the US already lost the AI culture war to China—and it wasn't the technology that failed. While Biden's team played Manhattan Project with closed models, Chinese developers quietly captured the open-source heartbeat of global AI through DeepSeek, now running inside every major US company and university lab. The kicker: Goog…

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The Secret Marketing Strategy That Built a16z: From Zero to Legendary VC Firm 59:55

23d ago59:55

59:55

Marc Andreessen and Ben Horowitz sit down with Margit Wennmachers—the woman who turned two unknown entrepreneurs with $300 million and zero investing track record into the most talked-about firm in venture capital. She unpacks how they weaponized transparency in an industry built on secrecy, why Fortune's cover story triggered a cartel meltdown, an…

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How Marc Andreessen Actually Uses AI 34:02

24d ago34:02

34:02

Half a billion people can access the world’s best AI on their phone. So why are most using it to write emails while only some are using it to build empires? In this conversation with Mark Halperin from Next Up, Marc Andreessen reveals why small bakeries are beating Fortune 500 companies at AI adoption, how to turn ChatGPT into your personal board o…

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The 2045 Superintelligence Timeline: Epoch AI’s Data-Driven Forecast 1:00:10

25d ago1:00:10

1:00:10

Epoch AI researchers reveal why Anthropic might beat everyone to the first gigawatt datacenter, why AI could solve the Riemann hypothesis in 5 years, and what 30% GDP growth actually looks like. They explain why "energy bottlenecks" are just companies complaining about paying 2x for power instead of getting it cheap, why 10% of current jobs will va…

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#747: Unpacking Automated Reasoning: From Mathematical Logic to Practical AI Security 38:02

18d ago38:02

38:02

Discover how AWS leverages automated reasoning to enhance AI safety, trustworthiness, and decision-making. Byron Cook (Vice President and Distinguished Scientist) explains the evolution of reasoning tools from limited, PhD-driven solutions to scalable, user-friendly systems embedded in everyday business operations. He highlights real-world examples…

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336 | Anil Ananthaswamy on the Mathematics of Neural Nets and AI 1:14:11

25d ago1:14:11

1:14:11

Machine learning using neural networks has led to a remarkable leap forward in artificial intelligence, and the technological and social ramifications have been discussed at great length. To understand the origin and nature of this progress, it is useful to dig at least a little bit into the mathematical and algorithmic structures underlying these …

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Robinhood CEO: Making Everyone An Owner 1:05:02

28d ago1:05:02

1:05:02

Vlad Tenev built Robinhood by breaking every rule Wall Street wrote: zero commissions when competitors charged $10, mobile-first when "serious" investors demanded desktop, a brand that made finance feel like rebellion instead of a club you'd never join. By 2021 they'd forced every major brokerage to slash fees and attracted millions who'd never own…

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Can Community Banks Survive the Next SVB? | ModernFi CEO Paolo Bertolotti and Former Comptroller Gene Ludwig 43:42

29d ago43:42

43:42

The former bank regulator who invented deposit networks just revealed why SVB's collapse was inevitable—and why the solution that could have saved them is finally being rebuilt. Gene Ludwig ran the OCC during the Clinton administration, created a half-trillion-dollar market solving a problem his Aunt Betty faced riding buses between banks, then wat…

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Ben Horowitz & Marc Andreessen: Why Silicon Valley Turned Against Defense (And How We’re Fixing It) 1:16:13

30d ago1:16:13

1:16:13

Palmer Luckey got fired from Meta for backing the wrong candidate—now he's the hero saving American defense, and that shift tells you everything about how fast the ground moved beneath Silicon Valley's feet. For decades, tech and defense were allies, then came 15 years of hostility so visceral that Google employees revolted over a Pentagon AI contr…

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AMA | November 2025 3:34:18

1M ago3:34:18

3:34:18

Welcome to the November 2025 Ask Me Anything episode of Mindscape! These monthly excursions are funded by Patreon supporters (who are also the ones asking the questions). We take questions asked by Patreons, whittle them down to a more manageable number -- based primarily on whether I have anything interesting to say about them, not whether the que…

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Emmett Shear on Building AI That Actually Cares: Beyond Control and Steering 1:10:36

1M ago1:10:36

1:10:36

Emmett Shear, founder of Twitch and former OpenAI interim CEO, challenges the fundamental assumptions driving AGI development. In this conversation with Erik Torenberg and Séb Krier, Shear argues that the entire "control and steering" paradigm for AI alignment is fatally flawed. Instead, he proposes "organic alignment" - teaching AI systems to genu…

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#746: AWS Regional Planning Tool, MCP Proxy for AWS, and Lots More!!! 30:01

30d ago30:01

30:01

There are so many updates this week you might need two cups of coffee! Simon and Jillian guide your way.By Amazon Web Services

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Can America Win The AI Biotech Race Against China? | Lada Nuzhna & Elliot Hershberg 1:02:23

1M ago1:02:23

1:02:23

Two venture capitalists dissect why biotech burns billions while China runs trials in weeks—and why the next Genentech won't look anything like the last one. Elliot Hershberg reveals the "three horsemen" strangling drug development as costs explode to $2.5 billion per approval, while Lada Nuzhna exposes how investigator-initiated trials in Shanghai…

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The Cosmic Egg: Where Ancient Myths and Modern Physics Meet 27:24

1M ago27:24

27:24

https://www.TheForbiddenKnowledgeNetwork.com Across cultures and continents, ancient civilizations spoke of a Cosmic Egg — a primordial sphere that cracked open to create the universe. Thousands of years later, modern physics reveals a startling parallel: the universe may have originated from a single ultra-dense point containing all matter, energy…

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The Frontier of Spatial Intelligence with Fei-Fei Li 44:11

1M ago44:11

44:11

Fei-Fei Li and Justin Johnson are pioneers in AI. While the world has only recently witnessed a surge in consumer AI, they have long been laying the groundwork for the innovations transforming industries today. With the recent launch of Marble, the first product from their company World Labs, we are revisiting this conversation to explore the ideas…

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Rocket Companies CEO: Here’s How to Fix the Housing Crisis 55:55

1M ago55:55

55:55

The Empire State Building took 110 days to build—today, changing a window would take two years. Alex Rampell (a16z) and Varun Krishna (Rocket CEO) expose how asset inflation turned housing from the American Dream into a wealth transfer machine where the median homebuyer age jumped from 30 to 38 in just fourteen years. While Silicon Valley burns bil…

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Grant Lee: Building Gamma’s AI Presentation Company to 100 Million Users 53:17

1M ago53:17

53:17

Grant Lee was told Gamma was "the worst idea ever heard" by an investor who hung up mid-Zoom—yet he built it to 100 million users and $100M ARR without spending a dollar on advertising. While competitors hired aggressively, Grant's team of seven refused to grow, dedicating 25% of their tiny team to design and personally onboarding every influencer …

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Michael Truell: How Cursor Builds at the Speed of AI 27:30

1M ago27:30

27:30

When four MIT grads decided to build a code editor while everyone else was building AI agents, they created the fastest-growing developer tool ever built. Cursor CEO Michael Truell joins a16z’s Martin Casado to discuss the deliberate constraints that led to breakthroughs: why they rejected the "democratization" narrative to focus on power users, ho…

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335 | Andrew Jaffe on Models, Probability, and the Universe 1:17:38

1M ago1:17:38

1:17:38

Science has an incredibly impressive track record of uncovering nonintuitive ideas about the universe that turn out to be surprisingly accurate. It can be tempting to think of scientific discoveries as being carefully constructed atop a rock-solid foundation. In reality, scientific progress is tentative and fallible. Scientists propose models, assi…

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#745: Accelerating Cloud Migration: How Occidental Petroleum Transformed with Terraform and AFT 20:19

1M ago20:19

20:19

This episode features a deep dive into Occidental Petroleum’s cloud migration journey, emphasizing automation and scalability. Brian Moore, a Cloud Architect at Occidental Petroleum, discusses how they used Terraform and AFT to streamline account provisioning, manage complex network architectures, and improve operational efficiency. The conversatio…

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a16z's State of Crypto: The $4 Trillion Milestone and What's Next' 1:38:31

1M ago1:38:31

1:38:31

The regulatory environment has completely inverted. Stablecoins are now a top 20 holder of US treasuries. Every major bank wants in. In a16z Crypto's 2025 State of Crypto report, Daren Matsuoka (Head of Data) and Eddy Lazzarin (CTO) reveal how crypto hit $4 trillion market cap while fundamentally reshaping how institutions think about payments, wit…

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Amjad Masad & Adam D’Angelo: How Far Are We From AGI? 1:02:44

1M ago1:02:44

1:02:44

Adam D’Angelo (Quora/Poe) thinks we're 5 years from automating remote work. Amjad Masad (Replit) thinks we're brute-forcing intelligence without understanding it. In this conversation, two technical founders who are building the AI future disagree on almost everything: whether LLMs are hitting limits, if we're anywhere close to AGI, and what happen…

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Mark Zuckerberg & Priscilla Chan: How AI Will Cure All Disease 45:21

1M ago45:21

45:21

Priscilla Chan and Mark Zuckerberg join a16z’s Ben Horowitz, Erik Torenberg, and Vineeta Agarwala to share how the Chan Zuckerberg Initiative is building the computational tools that will accelerate the cure, prevention, and management of all disease by century's end. They explain why basic science needs $100 million-scale projects that traditional…

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Seeing The Future from AI Companions to Personal Software 50:20

1M ago50:20

50:20

Eugenia Kuyda, CEO of Wabi and AI pioneer behind Replika, joins Erik, Anish, and Justine to reveal how personal software will transform from a developer monopoly to a creative medium for all. She exposes why command-line AI interfaces are the new MS-DOS, explains how mini-apps will become as shareable as TikToks, and details her decade-long journey…

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ElevenLabs CEO: Why Voice is the Next AI Interface 31:14

1M ago31:14

31:14

ElevenLabs CEO and co‑founder Mati Staniszewski joins Jennifer Li to explain how the team ships research‑grade AI at lightning speed—from text‑to‑speech and fully licensed AI music to real‑time voice agents—and why voice is the next interface for human‑computer interaction. He shares the small, autonomous team model, global hiring approach, and how…