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SKRAPS: Deep Dive

Caprino Studio

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SKRAPS is your podcast where we, on your behalf explore the stories of sparks of scientific brilliance in science and innovation. SKRAPS is the word sparks spelt backwards and also a play on the idea that ideas are written on back of a napkin or scraps of paper. We explore stories of people in science, while elaborating on the scientific details so that experts and non-experts can relate to science better in today's whimsical world that acts to spread mis-information.
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Safe and Effective

Human Factors Cast

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If you're interested in staying informed about the latest developments in medical human factors and user experience, then Safe and Effective is the podcast for you. We bring you lessons learned, case studies, and regulatory updates, through our conversations with experts from industry, academia, and government to share their insights and experiences with you. Join us as we explore the world of human factors and its impact on the medical field. Whether you're an industry expert or a novice lo ...
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How do we even know what constitutes the heart beat? What was the reason for all those abnormal rhythms of the heart? Why does it happen? The answer lies in the small, cylindrical glass tube called the micropipetter, which was used to create a microelectrode. Here it is, on how the microelectrode changed the face of cardiology. SKRAPS is your podca…
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Join us in our latest episode of Safe and Effective, where we take a deep (and possibly exasperated) dive into one of the most debated regulatory guidances in the drug-device combination product world — the FDA’s Comparative Analyses and Comparative Use Human Factors Studies Guidance — with none other than our dear friend, industry powerhouse, and …
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What connects Tudor England, Ann Boleyn, Henry the VIII, autonomic nervous system and a flash mob like wave of a deadly disease? There is only way to find out. Inspired by this paper and Dr. Ali Christy's X thread. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of sparks of brilliance…
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This story was inspired by the post on X by Dr. Farsad Mostashari. Center for Disease Control has been at the forefront of many of the alerts (true and false) and now it's officially gone... This is a sombre take on what has happened. SKRAPS is your podcast, where we on your behalf explores unsaid, underappreciated and sometimes, untold stories of …
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I can no longer be silent. I really believed better for us. Despite all the division in this country, I believed in the true American spirit. That when we are in crisis, we rally, we come together, we unify, we stand next to each other, and we support each other, and we fight for each other. But I guess those times are over. Or maybe they were neve…
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Join us in our latest episode of Safe and Effective, where we dive headfirst into the wild and wonderful world of integrating agile development methodologies into HF (Human Factors) and UX (User Experience) research operations, with none other than our friend, favorite human, and podcast bestie, Nick Roome. We kick things off by tackling age-old qu…
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Join us in our latest episode of Safe and Effective, where we welcome our new friend Kate Preston and our Human Factors Cast family member Barry Kirby to have a chat with us about AI in Healthcare and Medical Device and Development and HumanFactors and its current and future challenges, as well as the implications for such. AI in medical device dev…
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Join us in our latest episode of Safe and Effective, where we welcome back our good friend Dr. Albert Boquet to talk about using an existing framework, such as HFACS, to develop a unified use error classification system and database to add as a tool to the human factors engineering process in the medical device and combination product (development)…
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Join us in our latest ‘Let’s Get Real’ episode of Safe and Effective, where we delve into a nuanced and multi-faceted conversation with Rebecca Grier, a behavioral science expert in human factors and UX in the tech industry, discussing the broader issues of inequities and inequalities faced by women in the workplace, with a focus on behavioral scie…
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In today’s episode of Safe and Effective we are featuring an excerpt of the previously recorded Human Factors Cast show in which Nick Roome and our host Heidi Mehrzad shared their personal experiences living with ADHD and AuDHD/ASD and discussed the various ways in which their neurodiversity impacts their lives. From professional to personal relati…
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Join us in our latest episode of Safe and Effective, in which we launch our newest segment ‘Let’s Get Real’ - where we drop all filters and stop masking and get real about special and sometimes sensitive topics and issues. In our first ever Let’s Get Real segment we talk with Christy Harper, usability expert and co-founder of End-to-End User Resear…
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Join us in our fourth episode of Safe and Effective, where we dive deep with Helene Quie, regulatory and clinical expert, and founder and CEO of Qmed Consulting A/S in Copenhagen, Denmark. Together, we explore the pivotal role of a collaborative approach between clinical and human factors teams in order to align with regulatory requirements as well…
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In our third episode of Safe and Effective, we talk to Bert Boquet about the intricacies of the ever-present data debate of qualitative vs. quantitative in the sphere of medical human factors summative (validation) studies. In our discussion we shed light on the complexities of choosing the right data type and formulating an effective experiment de…
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In our second episode of Safe and Effective, we bring you multi-faceted conversation about human factors in medical device development from the unique perspective of a device engineer, Maggie Reiff. We talk to Maggie about her experience with integrating human factors into the device engineering process and what her lessons learned along the way we…
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In the premiere episode of Safe and Effective we bring you an exciting blend of regulatory insights and live interviews from this years HFES Healthcare Symposium in Orlando, Florida. In our first regulatory roundup segment ever we talk to Janet Creaser about the FDA’s newest human factors draft guidance released in December 2022, Content of Human F…
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If you're interested in staying informed about the latest developments in medical human factors and user experience, then Safe and Effective is the podcast for you. We bring you lessons learned, case studies, and regulatory updates, through our conversations with experts from industry, academia, and government to share their insights and experience…
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JoJo and Arun are producing some key content that will make you turn your heads in disbelief. Until then, we thought it would be good to get your mind focussed on that wonderful molecule - serotonin that has received fresh life due to its impact on mental health, be it with psychedelics or with electrical stimulation for depression etc. This episod…
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What Is a BCI? And just as importantly, what isn’t a BCI? This is an unusual episode and an incredibly fun one. Arun and JoJo enlisted some of the field’s top folks to talk through what’s in and what’s out in this exciting field. Amy Kruse is a general partner at Prime Movers Lab and a self-professed Founder turned Funder (and a neuroscientist by t…
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At SKRAPS, we are always looking to get behind the veil of the happenings in the field. We want to go beyond the facade of the news headlines. In recognition of this, we are now reading the slug for part 1 of candid conversations or plainly put - “Cutting through the crap in Bioelectronics”. So, we are joining Dr. Robert Spoelgen, Head of Bioelectr…
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Julia Child was a master. She was not a classically trained chef, but pursued cooking as a hobby. Her super power? Passion. A passion for making gastronomy accessible, to deliver an honest and attainable presentation, and she possessed a pure, unadulterated joy for her craft. While Michael Ackermann isn’t a neurotechnolgy hobbyist, he does share ot…
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Skraps is turning two. Or is it our second anniversary? I can't quite decide so let's celebrate both. Join us as we walk down memory lane with some highlights (and hopefully no lowlights) of the past two years of their audio partnership. Re-live some of our favorite moments - laughter, tears, learning, and even occasionally, listening. We revisit e…
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Hello friends and dear listeners, Recently, we were urged by a couple of our British listeners and experienced audio producers in the podcasting space, to nominate our last season’s science documentary podcast on Psychedelics for the British Podcast awards. Without further adieu, here is the 30 minute tape we sent for the second stage of the nomina…
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Funding for Bioelectronic Medicines does not come from traditional venture capital. It also comes from grant funding agencies. While the most well known grant funding bodies are NIH and DARPA in this area, there is also a renewed deeper interest in funding early research to develop products for clinical applications from the EU as well. So we invit…
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“Laugh and the world laughs with you. Snore and you sleep alone” is a famous quote from the author Anthony Burgess. Sleep Apnea affects 425 million adults over the age of 40. Yet, good treatments are unavailable. In this episode we address how Bioelectronic Medicines helps to alleviate the problem. Links as promised: Inspire Medical - the first hyp…
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We are joined by Imran Eba of GlaxoSmithKline's Bioelectronic Medicine fund - Action Potential Venture Capital to talk about investing in Bioelectronic Medicines. APV is the only fund that invests exclusively in bioelectronic medicines - and they've been here since the beginning. This leads to the ongoing question: what is and what is not a bioelec…
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Most of us can pretty certainly say that we are alone within our heads. We may joke about inner voices, but what really happens when there genuinely is an external influence deep within a brain? The answer? In the case of two research pioneers, Ian Burkhart and Benjamin Stecher, the answer is nothing short of a miracle. These two souls both underwe…
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PUT YOUR HEADPHONES ON! What does a 4 cm long and 25g in weight crustacean have to teach us about Bioelectronic Medicine and human health? And what does its feeding habits have to tell us about how we deal with tumours? Well, there is more than what meets the eye! If we reveal more than this, we are breaking the plot to you and making your life eas…
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The saying, as grotesque as it might be, goes "there's more than one way to skin a cat." In our case, there's more than one way to stimulate a nerve and we've gathered some experts leading the charge (pun very much intended.) Gather around the fire, bring some marshmallows and listen in as we chat with Hubert Lim of the University of Minnesota, Chr…
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Have you ever wondered what decisions go behind deciding if a pharmaceutical is to be administered either orally or intravenously or via inhalation. Who decides that? Well, the short answer is that it is decided based on a tested pharmaceutical developmental framework that has stood the test of time. First, it is determined by a clinical need, then…
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Join Arun & JoJo as they go behind the wall of the science that underpins new treatments for Major Depressive Disorder (MDD). While MDD is the leading cause of both personal and societal disability, there are still inadequate treatment options. But the advent of two very areas are bringing hope! The first area is psychedelic assisted psychotherapy …
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The NIH's Neuromodulation Prize was announced on Jan 17, 2002. The $9.8 million dollar prize pot will be awarded over three phases. So we did an interview for Ladan Jiracek & Neural Implant Podcast around this prize, purely because Arun has experience in working as part of the team that did the GSK Innovation Prize. If anyone has not listened to La…
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What in the world is a Bioelectronic Medicine? As promised, link to schema below 👇🏻👇🏻 Link to Schema on Bioelectronics Medicines Framework: here SKRAPS will remain free, but the production is not. If you would like to help us, please visit here. Episode Description: “Tis but thy name that is my enemy; Thou art thyself, though not a Montague. What’s…
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As promised last month, here is part 2 of the story of sound design for the PsychedeRx series - a documentary exploring the therapeutic potential of psychedelics. This series in its entirety can be accessed here using this LINK and PODCAST PLAYER of your choice. The transcripts of every episode is located at our website: www.psychederx.com Remember…
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We talked before about the different ways to make a career in science. We've had people from finance, and entrepreneurs driving the start-up world. We've even had a scientific illustrator. There's one area of science and technology that we're covering for the first time today - this one is near and dear to our hearts because it's something that we …
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Recently, one of our loyal listeners sent a very kind message. It was extremely appreciate of our PsychedeRx series and asked a key question about how we went about doing the music as they referred to. That's when I realized that what I had taken as a necessary and mandatory part of our podcast was appreciated by the listener. It was a very pleasan…
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This re-run was triggered by a news article of a horrible event in Ecuador where a prison riot killed 68 people. Such type of events are becoming increasingly commonplace due to organised crime. The rioters and instigators must be dealt with appropriately to control the violence, but beyomnd that where does that leave us? We can take one stance, wh…
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It's the climate change summit week. So in preparation for everyone, we wanted to re-run this crucial episode that we hope everyone gets to listen to. She gives a personal viewpoint as a scientist, coming from a coal-mining family and being the first graduate in her family to going on to be the Vice-Provost and Chief Research Officer of Villanova U…
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It's the start of Season 4 of SKRAPS. So first, credit where it is due, thanks so much for the support! Have you ever wondered where the food you eat comes from? No, we do not talk about your carbon footprint or the location of the farm Food and flavour evokes a strong sense of nostalgia, likes and dislikes in our mind so much so that a particular …
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If you’ve listened to the PsychedRx series, or ever contemplated experiencing psychedelics, you’ve probably asked yourself what a trip is really like. Well, I’d very much like to tell you what it’s like, but it’s much like trying to describe an exact shade of purple velvet. It’s deep, rich, bright, dark, it changes as the light shifts. When you tou…
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October 4, 2021 marked the announcement of the Nobel Prize in Physiology and Medicine to Dr. David Julius and Dr. Ardem Parpoutian. This episode goes behind the relevance of their findings and why it is such an important moment for a field that brings together biology, physics, chemistry and medicine. Key Reviews to dig into: TRP channels: Click he…
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Hello all, This is JoJo, your friend and co-host of SKRAPS. I grew up around construction. Tradesmen and experts at the crafts of building and repairing homes were omnipresent in my childhood. From a very young age, I knew more about framing than I did about Barbie dolls. I was comfortable in the world of power tools and knew the importance of “mea…
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Join us to listen to the bi-weekly news round up on all things #NeuroTech and #BioelectronicMedicine. This week we talk about academic news with Cleveland NeuroTech Entrepreneurs workshop, UConn hiring spree in Engineering with focus on NeuroTech. On industry side, we cover Rune Labs, Tivic Health, Opinions on Nyxoah and their FDA breakthrough desi…
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Over the ten episodes in this series, it’s clear that we are enthusiastic about the future of psychedelic medicines. There are so many potential applications for responsible, physician-assisted therapies that it almost seems as though psychedelics are a silver bullet, or a little black dress - perfect for any occasion and applicable to myriad disea…
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New molecules, new IP, new opportunities. How can investors be induced to support the massive, but necessary funds required to support the important and carefully regulated research necessary to bring psychedelic therapies to market. Not to be crass, but if something isn’t going to bring a profit, it’s unlikely to receive much funding, regardless o…
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Mushrooms changed the world in the 20th century, some say. Others say, psychedelics are older than humankind. But instead of synthesising molecules and providing it people in a clandestine manner, what if, proper systematic drug discovery and development was done to make psychedelics better? In this penultimate episode of PsychedeRx, we explore a f…
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