Best José Chan Podcasts (2025)

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31 Oct - CAF Champions League - key Morocco football academy - U17 World Cup - Iwobi reaches EPL milestone 29:30

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4d ago29:30

29:30

This week we catch up on the teams that have made the group stage of the CAF Champions League, as South Africa’s Orlando Pirates missed out. Also we go to Morocco and find out about the Mohammed VI Football Academy, a key factor in Morocco’s success in winning the Fifa Under-20 World Cup. We look ahead to the Fifa U-17 Men’s World Cup, which starts…

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202: Fighting Antimicrobial Resistance: How AI Cuts Phage Therapy Access from 6 Months to 5 Days with José Bila - Part 2 24:00

5d ago24:00

24:00

What if the answer to battling antibiotic-resistant infections isn’t a new antibiotic, but harnessing viruses that have been quietly dominating bacterial populations? Bacteriophages, viruses that target and kill bacteria, have been saving lives for a century, but their true potential is only now being unlocked by modern machine learning. The race i…

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201: Fighting Antimicrobial Resistance: How AI Cuts Phage Therapy Access from 6 Months to 5 Days with José Bila - Part 1 24:46

7d ago24:46

24:46

Antibiotic resistance isn’t just a looming problem. It’s a global crisis. Every year, more than one million people die directly from resistant infections, and another 5 million die indirectly. Routine infections are becoming life-threatening, and healthcare systems worldwide are under pressure. Despite decades of warnings, pharmaceutical solutions …

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24 Oct- Morocco U20 World Cup success - Hakimi heads African top player list - Frank Onyeka - Utd beat Reds 29:30

11d ago29:30

29:30

This week we talk about Morocco’s success in winning the Fifa Under-20 World Cup in Chile, becoming the second African team to win the trophy. Also, Achraf Hakimi heads the 10-man shortlist for the African Footballer of the Year award. We look at the main contenders. We speak to Nigeria and Brentford midfielder Frank Onyeka, on life in London and o…

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200: Mastering Quality by Design: From Product Failures to Commercial Success in Biologics CMC Development - Part 2 20:32

12d ago20:32

20:32

Your process works perfectly at two-liter bench scale. Then you hit fifty liters and titer drops 20%. By two hundred liters, aggregation appears and charge variants shift. Your management team asks: "How long to fix this?" The honest answer? Three to twelve month, because you're flying blind. In Part 2 of this Quality by Design Master Class, David …

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199: Mastering Quality by Design: From Product Failures to Commercial Success in Biologics CMC Development - Part 1 21:28

14d ago21:28

21:28

Over 40% of biotherapeutic failures during clinical development stem from stability problems—and most trace back to protein aggregation that could have been prevented. In this episode of the Smart Biotech Scientist Podcast, David Brühlmann exposes the hidden manufacturing crisis that derails promising biologics programs and delivers the systematic …

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17 Oct Cape Verde make World Cup history - Morocco in U20 WC Final - EPL managerial changes 29:31

18d ago29:31

29:31

This week we talk World Cup qualifying as the games concluded with Cape Verde claiming a historic maiden qualification, and with Cote d’Ivoire, Senegal, South Africa and Ghana also making it in the last round of matches. We analyse the action and also take a look at the play-offs. Also, Morocco are through to the final of the Under-20 World Cup, an…

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198: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 2 21:57

17d ago21:57

21:57

What happens when the most complex molecules in biotech meet the organizational challenge of managing 300+ analytical scientists? The answer lies not just in the science, but in building systems that turn technical complexity into reliable delivery. In Part 2 of our deep dive with Amanda Hoertz, VP of Analytical and Formulation Sciences at KBI Biop…

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197: Mastering ADC Development: CDMO Strategies for Analytics and Scale-Up with Amanda Hoertz - Part 1 25:58

21d ago25:58

25:58

What if the key to unlocking ADC manufacturing success lies in abandoning the platform mindset entirely? Antibody-drug conjugates represent biotech's most promising weapon against cancer: precision-targeted therapeutics that deliver cytotoxic payloads directly to tumor cells while sparing healthy tissue. But beneath the clinical promise lies a manu…

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10 Oct World Cup qualification - CAF profitability - apology to Osimhen 29:30

25d ago29:30

29:30

This week we talk World Cup qualifying as Egypt and Algeria book their spots, while Ghana are almost there and Cape Verde’s possible maiden qualification will go down to the final day. Also, CAF has announced a return to profitability after several years of losses – we look at the details. And former England striker Gary Lineker has apologised to N…

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196: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 2 25:04

26d ago25:04

25:04

What if solving tomorrow’s bioprocessing challenges meant questioning the very physics of chromatography and reimagining downstream processing from the ground up? For years, large biomolecules like viral vectors and exosomes have squeezed through the limitations of traditional chromatography, leaving scientists to wrestle with capacity trade-offs a…

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195: Monolithic Chromatography Innovations: Solving High-Capacity Purification for Gene Therapy Vectors with Alois Jungbauer - Part 1 20:48

26d ago20:48

20:48

By David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

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3 Oct - World Cup qualifying - 3 die in Morocco AFCON protests - Angola appoints Patrice Beaumelle - Liverpool wobble 29:27

1M ago29:27

29:27

This week we talk World Cup qualifying as South Africa have been docked three points, leaving Group C wide open. With Morocco hosting the AFCON in December and co-hosting the World Cup in 2030, three people are reported to have died as hundreds of young protesters have taken to the streets across Morocco to protest against the cost of the tournamen…

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194: Viral Vector CDMO Mastery: Singapore's Answer to Cell and Gene Therapy Supply Shortages with Lucas Chan - Part 2 19:18

1M ago19:18

19:18

What if the future of affordable, life-changing cell and gene therapies comes down to one critical yet often overlooked factor: manufacturing efficiency? In advanced therapy medicinal products (ATMPs), groundbreaking science abounds, but the path to the clinic is still strewn with bottlenecks, especially when it comes to cost, complexity, and safet…

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193: Viral Vector CDMO Mastery: Singapore's Answer to Cell and Gene Therapy Supply Shortages with Lucas Chan - Part 1 29:11

1M ago29:11

29:11

Viral vectors are the backbone of cutting-edge cell and gene therapies, delivering life-altering treatments to patients with genetic diseases. But making these biological delivery vehicles is a high-wire act: unpredictable, complex, and fraught with hurdles that traditional biologics manufacturers have never faced. While the world races toward next…

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26 Sept Ballon DOr awards - Salah Dembele Hakimi - Luca Zidane - Tolu Arokodare 29:21

1M ago29:21

29:21

This week we analyse the Ballon d’Or awards, as Mohamed Salah took fourth place behind Ousmane Dembele, and Achraf Hakimi was sixth – did they deserve higher rankings? Also, as Luca Zidane, the son of France legend Zinedine Zidane, has switched his international allegiance from France to Algeria, we ask whether Zinedine Zidane could have been the b…

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192: Process Intensification Secrets: A Process Engineer's Decision Framework with Andreas Castan - Part 2 19:43

1M ago19:43

19:43

Is continuous manufacturing delivering the transformative results everyone promised, or are you being sold an expensive solution to the wrong problem? While industry headlines tout revolutionary productivity gains, the economic reality behind continuous bioprocessing tells a more nuanced story that every process engineer needs to understand before …

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191: Process Intensification Secrets: A Process Engineer's Decision Framework with Andreas Castan - Part 1 21:16

1M ago21:16

21:16

What if process intensification could transform your bioprocessing economics without the complexity most engineers fear? Getting 3x productivity gains and 30-150% titer increases once seemed reserved for Big Pharma's endless R&D budgets, but a strategic approach to technology selection is making these results achievable for companies of any size. I…

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19 Sept - Serhou Guirassy - African legends on FIFA anti-racism panel - South African U17 Championship - Jose back at Benfica 29:31

2M ago29:31

29:31

This week we talk about the scoring exploits of Borussia Dortmund’s Guinean forward Serhou Guirassy, who’s continued his outstanding form into this new season. Also we look at the new FIFA anti-racism panel, which includes African football legends George Weah, Didier Drogba, Emmanuel Adebayor, Khalilou Fadiga and Mercy Akide – will it succeed in fi…

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190: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later) - Part 2 18:47

2M ago18:47

18:47

Still think you can "figure out CMC later"? Your competitors just implemented a systematic framework that cuts their IND timeline in half while you're still debating whether CMC matters. The founders who file INDs predictably aren't smarter than you. They just stopped gambling with ad-hoc CMC approaches and started executing proven systems. While y…

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189: Why Smart Biotech Founders Plan CMC First (While Competitors Burn Cash Later) - Part 1 16:04

2M ago16:04

16:04

Think you can crack the science first and worry about CMC when you "need it"? That's exactly how promising therapies die in regulatory limbo while patients keep waiting. Your breakthrough discovery means nothing if it's trapped in CMC chaos. While you're perfecting your molecular mechanism, competitors with inferior science but superior CMC strateg…

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12 Sept Africa and VAR - World Cup qualifiers as Nigeria struggle - UEFA Champions League and EPL 29:28

2M ago29:28

29:28

This week we catch up on the drama of the latest World Cup qualifiers in Africa, as Cape Verde are a win away from qualifying, Cameroon and Nigeria are in trouble, and North African teams are impressing. Also we talk about VAR in Africa. Outside of North Africa, only Mauritania is using the technology. We look at the prospects for the continent. An…

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188: From Biology Is Messy to Designable: The Smart Bioprocessing Transformation with Carmen Jungo Rhême - Part 2 24:41

2M ago24:41

24:41

For too long, biotech innovators have viewed biological systems as inherently messy, unpredictable, and full of “black box” mysteries. But what if, armed with the latest digital tools, AI, and cross-disciplinary thinking, you could transform bioprocessing from a series of trial-and-error experiments to a streamlined, proactive design process? Carme…

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187: From Biology Is Messy to Designable: The Smart Bioprocessing Transformation with Carmen Jungo Rhême - Part 1 21:19

2M ago21:19

21:19

Almost every corner of modern medicine and sustainable food production today is facing a massive challenge: how do we outpace drug-resistant “superbugs” and create food for a growing population using fewer resources? The answer, it turns out, may come down to how well we understand and control the biomanufacturing processes underpinning these bioma…

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5 Sept - top African EPL transfers Wissa - Arokodare - Jackson - plus Zim coach Michael Nees 29:27

2M ago29:27

29:27

This week we take a look at some of the big transfers made on deadline day – how will Yoane Wissa do at Newcastle, what about Wolves signing Nigeria striker Tolu Arokodare, and we talk about Senegal and Chelsea forward Nicolas Jackson joining Bayern Munich on loan. Also, with the latest rounds of World Cup qualifiers underway we hear from Zimbabwe …

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186: How Generative AI Accelerates Protein Design for Biotech Discovery with Elise de Reus - Part 2 17:33

2M ago17:33

17:33

Imagine unlocking a world where designing custom proteins is not only feasible - but faster, smarter, and more powerful than ever before, thanks to artificial intelligence. As the promise of programmable biology takes center stage, AI-driven protein engineering is rapidly moving from theoretical dream to industry standard. In this episode, David Br…

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185: How Generative AI Accelerates Protein Design for Biotech Discovery with Elise de Reus - Part 1 24:36

2M ago24:36

24:36

For decades, protein design has hinged on painstaking rounds of wet lab mutagenesis and trial-and-error, a process limited not by human ingenuity, but by time and complexity. Yet as the biotech field seeks faster, greener, and more effective solutions for therapeutics and industrial applications, the next leap might not come solely from the lab ben…

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29 Aug - CHAN Final Morrocco v Madagascar - Sudan joy with Kwesi Appiah - EPL 29:29

2M ago29:29

29:29

This week we’re at the CHAN again, the African Nations Championship in East Africa. It’s Morocco against Madagascar in the final this Saturday, as all three co-hosts went out at the quarter-final stage - Kenya, Tanzania and Uganda. We look ahead to the final and assess the tournament. We also look at Sudan’s success story as they reached the semi-f…

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184: From Lab to Market: Secrets to Commercializing Cutting-Edge Biotech Innovations with Chervee Ho - Part 2 19:21

2M ago19:21

19:21

What’s the secret to turning a cutting-edge scientific breakthrough into a commercial biotech success? For every inspiring lab discovery, countless prototypes stall before ever reaching the market. The barriers? Securing the right beta testers, outmanoeuvring industry giants, and building teams who understand not just the science, but the user expe…

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183: From Lab to Market: Secrets to Commercializing Cutting-Edge Biotech Innovations with Chervee Ho - Part 1 24:54

2M ago24:54

24:54

Every year, cutting-edge biomedical technologies are left stranded in the lab, not for lack of innovation, but because they miss the crucial leap from technical performance to genuine industry adoption. The gap between scientific brilliance and commercial success is deceptively simple: deeply understanding and building for your customer’s real-worl…

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22 August - CHAN quarter final line-up - Dango Ouattara - EPL opener lessons 29:28

2M ago29:28

29:28

This week we’re at the CHAN again, the African Nations Championship, with co-hosts Kenya, Tanzania and Uganda all through to the quarter-finals, Uganda doing it in truly dramatic fashion. With the EPL underway we highlight a few of the potential African stars this season, and we take a look at Burkina Faso forward Dango Ouattara’s move from Bournem…

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182: Innovating Continuous Bioprocessing with Vibrating Membrane Filtration with Jarno Robin - Part 2 17:04

2M ago17:04

17:04

What if the secret to making continuous bioprocessing practical, sustainable, and far simpler has been shaking - literally - just beneath our feet? For years, the industry has grappled with the complexities of continuous manufacturing, with technologies like ATF (alternating tangential flow) steadily dominating the perfusion landscape. But what if …

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181: Innovating Continuous Bioprocessing with Vibrating Membrane Filtration with Jarno Robin - Part 1 25:45

3M ago25:45

25:45

What if one of biotech’s biggest production breakthroughs was hiding in plain sight? Not in a new gene or a wonder drug, but in the way we process and purify biologics. Perfusion technology, once dismissed as a pipedream in top biopharma boardrooms, is now quietly powering some of the industry’s most efficient and productive manufacturing platforms…

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15 August - Nigeria out at the CHAN - Wilfred Ndidi part 2 - Man Utd EPL preview 29:30

3M ago29:30

29:30

This week we’re at the CHAN again, the delayed 2024 African Nations Championship, with Kenya, Tanzania and Uganda co-hosting. We’re getting to the end of the group stage, with Tanzania the first team to qualify for the quarter-finals, and Nigeria surprisingly the first team eliminated. Also we have the second part of our chat with Nigeria midfielde…

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180: How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay Davis - Part 2 26:52

3M ago26:52

26:52

The promise of advanced cell therapies is undeniable, but as demand skyrockets, the challenges of taking a living drug from bench to bedside have never been greater. Each batch brings variability, each jurisdiction adds regulatory hurdles, and every strategic decision can determine whether a lifesaving therapy reaches patients or fizzles out behind…

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179: How Mesenchymal Stromal Cells Are Transforming Care for Diabetes and Autoimmune Diseases with Lindsay Davies - Part 1 23:33

3M ago23:33

23:33

By David Brühlmann - CMC Development Leader, Biotech C-level Advisor, Business Strategist

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8 Aug - Tanzania & Kenya do well in African Nations Championship - Wilfred Ndidi 29:30

3M ago29:30

29:30

This week we’re at the CHAN again, the delayed 2024 African Nations Championship, with Kenya, Tanzania and Uganda co-hosting. A great start for Tanzania and Kenya, but Uganda have to recover from a crushing defeat to Algeria in their opener. Also we speak to Nigeria midfielder Wilfred Ndidi, on the Super Eagles struggles, and on the pain of relegat…