Best IMD Podcasts (2025)

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Is AI good or bad for sustainability? 26:01

Play Pause

2d ago26:01

26:01

AI is a double-edged sword for the environment. Its growth requires masses of energy, water, and rare earth metals. The LLMs of tomorrow may even require the world to bring old power plants, powered by fossil fuels, back online. On the other hand, AI has the potential to accelerate sustainable transformation by providing innovative approaches to en…

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IMD Research round-up: Glycogen Storage Disorders 32:51

8d ago32:51

32:51

In this episode, Dr Joost Groen, a clinical biochemist at the University Medical Center Groningen, and Dr Matt Gentry, Professor & Chair of Biochemistry & Molecular Biology in the College of Medicine at University of Florida, join Rodrigo and Silvia to discuss new insights, AI, cancer metabolism and some of their favourite papers on Glycogen Storag…

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Diagnostic delay in Metachromatic Leukodystrophy 21:31

1d ago21:31

21:31

Dr Laura Adang returns to the podcast, this time discussing diagnostic delays in early onset forms of metachromatic leukodystrophy and explains why the only logical route to prompt diagnosis is newborn screening and how gene therapy might lead to a 'normal' life for children, if only we can find them early enough.Characterizing Diagnostic Delays in…

1
Is AI good or bad for sustainability? 26:01

2d ago26:01

26:01

AI is a double-edged sword for the environment. Its growth requires masses of energy, water, and rare earth metals. The LLMs of tomorrow may even require the world to bring old power plants, powered by fossil fuels, back online. On the other hand, AI has the potential to accelerate sustainable transformation by providing innovative approaches to en…

1
First-time CEO pitfalls, and how to avoid them 32:49

9d ago32:49

32:49

What got you here won’t get you there. But that’s not all, says Kevin O’Brien, CEO of Gammon Construction in conversation with Professor Ric Roi. You’re also going to need to really unpack the detail of your new brief, marshal the data to spot the opportunities, figure out how to unlock future potential, and bring everyone with you on the journey.…

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“We were so scared of our IPO”: Leaders Unplugged with former On-CEO Marc Maurer 42:15

15d ago42:15

42:15

Marc Maurer didn’t build ON by playing it safe. In this live conversation with IMD’s Alyson Meister, the outgoing Co-CEO explains why betting on purpose, rejecting hype, and ignoring the industry playbook paid off: 1. Culture over hype. “We’re actually the anti-metaverse.” ON doubled down on real-life movement instead of pixels, and built a brand w…

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Future therapies in galactosemia 33:35

16d ago33:35

33:35

In this latest episode, we explore what's next for treating classic galactosemia. The discussion is anchored in two fascinating recent publications, including the wide-angle perspective from “Reshaping the Treatment Landscape of a Galactose Metabolism Disorder” and a deep dive into something delightfully unexpected: purple sweet potato color (PSPC)…

1
Halfway 2025: How to read two quarters under Trump 2.0 27:50

16d ago27:50

27:50

Richard Baldwin delves into the Trump administration, and what to glean from months of economic madness. Looking ahead, Richard discussed how trade and tariffs will directly impact businesses, from small enterprises to large corporations, and what business leaders can do to mitigate risk potential regional variations and sector-specific impacts.…

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Metabolic mysteries: GI bleeding, gallbladder polyps and evolving developmental delay 8:25

23d ago8:25

8:25

Dr JP Stevens shares the mystery of a 5-year-old boy presenting with severe gastrointestinal bleeding and cholestasis. Inpatient investigation reveals gallbladder polyps and, on assessment after recovery he is found to have signs of developmental delay. Can you recognise the clues in the presentation?https://onlinelibrary.wiley.com/doi/10.1097/PG9.…

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Why do the biggest headlines go to the worst leaders? Howard Yu and Martin Gutmann 40:24

28d ago40:24

40:24

Historian-turned-business-professor Martin Gutmann talks to IMD’s Howard Yu about busting the “hero” myth, how Churchill really won WWII, and the silent strategist who conquered both poles while the flashy explorers froze. Along the way he reveals humility as the ultimate power-skill and hands leaders a playbook for quietly, predictably winning.…

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Speech and Language in Batten disease 23:34

30d ago23:34

23:34

Lottie Morison joins the podcast to discuss recent insights around speech and language progression and assessment in CLN2 and CLN3 disease. Lottie is the first speech and language pathologist to lead an episode and brilliant exemplifies the multidisciplinary nature of IMD care. Speech, Language and Non-verbal Communication in CLN2 and CLN3 Batten D…

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Metabolic Minds 2025 23:41

1M ago23:41

23:41

A special episode of the podcast as we visit the presentation day for the Metbionet Metabolic Minds leadership programme to hear about a plan to safeguard the future of specialist biochemistry services in the UK. Dr Rachel Carling explains the programme and then we hear from three of the course candidates, Dr Alana Burns, Annabel Wong and Freya Has…

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IMD Research Round-Up: Redox metabolism 35:46

1M ago35:46

35:46

Dr Luciana Hannibal, Research Group Leader / Head of Translational Metabolomics at the Centre for Integrative Biological Signalling Studies in Freiburg, and Dr Julien Park, a Physician-scientist at the Children's University Hospital Münster, are Rodrigo and Silvia's latest guests, providing a thorough overview of disorders of Redox Metabolism. Auth…

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In an age of grievance, find every opportunity to listen - Cynthia Hansen and Richard Edelman 20:12

1M ago20:12

20:12

Richard Edelman, CEO of the communications firm Edelman, explores in a conversation with Cynthia Hansen, Managing Director of Adecco Group’s Innovation Foundation, why so many people are dissatisfied with authority and institutions.By IMD

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ECHS1 deficiency and valine restriction 14:42

1M ago14:42

14:42

Dr Travis Johnson and Dr Sarah Mele join the podcast to explain why flies make great models for Short-chain enoyl-CoA hydratase 1 deficiency (ECHS1D) and how their work is shedding light on different treatment modalities.Valine Restriction Extends Survival in a Drosophila Model of Short-Chain Enoyl-CoA Hydratase 1 (ECHS1) DeficiencySarah Mele, et a…

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Metabolic mysteries: A child with episodic seizures and multiple diagnoses 5:21

2M ago5:21

5:21

Dr Mrinmayee Takle and Dr Kuntal Sen discuss the challenging dilemma of a child, presenting from infancy with recurrent seizures and three different (wrong) diagnoses including opsoclonus-myoclonus-ataxia syndrome.Read the article: https://doi.org/10.1002/cns3.20098Mrinmayee Takle, Dhwani Sahjwani, Diana Bharucha-Goebel, Tyler Rapp, Cecilia Bouska,…

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From the classroom to the boardroom – why do IMD alumni lead differently? 26:29

2M ago26:29

26:29

Three alumni. Three decades. One question: What makes IMD’s leadership journey so lasting? What do a former Olympic basketball player, a Japanese strategist in London, and a Swiss energy executive have in common? IMD. In this special MBA reunion episode of Leaders Unplugged, IMD President David Bach welcomes - John Hatch (MBA 1990) - Kazumi Nakayam…

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Managing Metabolic Emergencies - Intoxication type disorders 26:35

2M ago26:35

26:35

Treatment is available for most intoxication-type disorders, but would you know what to do in an emergency. In this podcast, Dr Dexter Tarr discusses the acute management when these conditions cause encephalopathy, seizures, stroke-like episodes, thromboses, liver failure, cardiac failure, arrhythmias and rhabdomyolysis. Emergency Management of Int…

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IEMs in Adult Metabolic Centres: 10 Years Later 22:50

2M ago22:50

22:50

Michel Tchan and Mirjam Langeveld join the podcast to look at changes to adult IMD services over the last decade and consider the challenge to develop services to meet the needs of growing patient numbers over the next 10 years.The Frequencies of Different Inborn Errors of Metabolism in Adult Metabolic Centres: 10 Years Later, Another Report From t…

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How do deans lead when the world turns upside down? 38:28

2M ago38:28

38:28

Global deans on leading through turbulence — and why optimism, not certainty, is the real power in today’s business education. In today’s episode, IMD President David Bach discusses how the rapid global shifts of the moment impact leadership education, with two of his peers: – Catherine Duggan, Dean of the University of Cape Town Graduate School of…

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IMD Research Round-Up: Methylmalonic Aciduria 34:17

2M ago34:17

34:17

Dr Sabine Fuchs, Professor of Metabolic diseases and innovative therapies at the UMC Utrecht, and Dr Sean Froese, a Principal Investigator in the Metabolism Division at University Children’s Hospital Zürich, join Rodrigo and Silvia to discuss new insights and some of their favourite papers on Methylmalonic Aciduria. Authors opinions are their own a…

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Shortcast: Sleep quality in children with hepatic GSDs, a prospective observational pilot study 8:38

3M ago8:38

8:38

Lucas Agnoletto and Dr Rebecca Halligan report work looking at sleep quality in children with hepatic GSDs, considering whether sleep is impacted by poor glycemic control or our efforts to improve this through overnight feeding.Sleep quality in children with hepatic glycogen storage diseases, a prospective observational pilot studyLucas Agnoletto, …

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David Bach: Why we all benefit from America’s top universities 35:45

3M ago35:45

35:45

In the latest episode, IMD President David Bach explains the vital importance of the partnership between the US government and the elite research universities, what we can learn from the vibrancy of the Middle East, and why Ted Lasso is a better leadership role model than Elon Musk. “The US built its global edge by attracting the world’s best. Now,…

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NAXD deficiency 32:57

3M ago32:57

32:57

Dr Carole Linster and Dr Nicole van Bergen explain why metabolism isn't perfect and how disorders of enzyme repair present their own challenges. In an episode that explores Niacin and longevity, we also hear why NAXD deficiency is an important differential in acute cardiomyopathy and provides an aetiology that could be highly amenable to treatment.…

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Imaging readiness in the gene therapy era 22:54

3M ago22:54

22:54

Asthik Biswas, Spyros Batzios, and Kshitij Mankad expand on their recent letter to the editor to explain why ushering in the new era of gene therapy treatments requires not just clinical but also imaging readiness. Imaging readiness in the gene therapy era-exploring standardized protocols for response assessmentAsthik Biswas, et alhttps://doi.org/1…

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Episode 3: David Bach with Stuart DeCew and Geraldine Matchett 38:23

3M ago38:23

38:23

Welcome to the third episode of Leaders Unplugged, presented by IMD, and hosted by IMD's president David Bach, together with Remote Daily's founder Felix Zeltner. Leaders Unplugged is real talk with the impactful – candid, honest, and fresh from behind the scenes. Today, we take you behind the scenes of a recent gathering led by the World Business …

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IMD Research Round-Up: Congenital Disorders of Glycosylation 39:58

3M ago39:58

39:58

Dr Matthew Wilson, Postdoctoral Fellow at the Centre for Human Genetics, KU Leuven, joins hosts Silvia Radenkovic and Rodrigo Starosta to discuss a scintillating selection of CDG papers in our first ever research round-up. Authors opinions are their own and do not represent their institutions.The papers discussed include:A pseudoautosomal glycosyla…

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Exploring the disease burden in Arginase 1 deficiency 27:51

3M ago27:51

27:51

It's an Arg1 extravaganza as Reena Sharma, Sara Olofsson, Karolina Stepien and Alison Woodall discuss three separate papers looking at the Salford Royal experience of a cohort of adults with Arginase 1 deficiency and the wider health and societal cost of the condition. Retrospective analysis of arginase 1 deficiency progression in adults over 5 yea…

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The Interview: Jim Pulcrano speaks with Ruchita Sinha of AV8 Ventures 17:54

3M ago17:54

17:54

This interview with Ruchita Sinha, partner at AV8 Ventures, explores her journey from science to venture capital and her approach to early-stage investing. She discusses AV8’s focus on AI-driven innovation in healthcare, enterprise tech, and financial services, and shares insights on evaluating founders, what distinguishes a good company builder, n…

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Episode 2: David Bach and UBS CEO Sergio Ermotti 32:34

4M ago32:34

32:34

Welcome to the second episode of Leaders Unplugged, a bi-weekly podcast by IMD, hosted by IMD President David Bach with Felix Zeltner. In this wide-ranging chat, David goes from the global to the personal with one of the world’s most prominent bankers: UBS CEO Sergio Ermotti. At a recent event in Lausanne, Sergio Ermotti joined Bach on stage and pu…

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Shortcast: D,L-3-hydroxybutyrate in the treatment of glucose transporter 1 deficiency syndrome (Glut1DS) 5:12

4M ago5:12

5:12

In this Shortcast, Dr Aya Amer presents the New Zealand experience of using ketone (D,L-3-HB) supplementation in 12 patients (aged 10-50 years) with GLUT1DS.D,L-3-hydroxybutyrate in the treatment of glucose transporter 1 deficiency syndrome (Glut1DS)Aya Amer, et alhttps://doi.org/10.1002/jmd2.12461By Journal of Inherited Metabolic Disease

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Can biodiversity credits alter the landscape for nature conservation? 25:49

4M ago25:49

25:49

IMD Senior Researcher Adrian Dellecker is joined in the latest I by IMD podcast by Mariana Sarmiento, Founder and CEO of Terrasos, a company developing innovative solutions for environmental conservation and restoration. In this episode, you will learn about the business opportunities in the new market for voluntary biodiversity credits and more. F…

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Can eDNA revolutionize biodiversity monitoring? 31:43

4M ago31:43

31:43

IMD Senior Researcher Adrian Dellecker is joined in the latest I by IMD podcast by Kristy Deiner, a well-respected academic and entrepreneurial figure in Environmental DNA (eDNA) science. She was a professor on the subject at ETH Zurich, and in 2021 she co-founded SimplexDNA, where she is now CEO. In this episode, you will learn some fundamentals o…

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Citrulline: beyond the urea cycle 26:29

4M ago26:29

26:29

Marshall Summar explains why common polymorphisms and basic physiology mean that L-citrulline may have a role in sickle cell disease, bronchopulmonary dysplasia and even asthma.Potential therapeutic uses of L-citrulline beyond genetic urea cycle disordersMarshall Summarhttps://doi.org/10.1002/jimd.12810…

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The Interview: Howard Yu speaks with Julie Linn Teigland of EY 32:57

4M ago32:57

32:57

Leaders are under pressure to project certainty and to know all the answers. In this interview podcast, Julie Linn Teigland, a Managing Partner at EY, tells IMD’s Howard Yu why it’s better to admit you’re unsure and collaborate to find a solution. ***** Read our magazine, I by IMD, here: https://www.imd.org/ibyimd/ Discover IMD's leadership program…

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Welcome to Leaders Unplugged! 30:49

4M ago30:49

30:49

Welcome to the inaugural episode of Leaders Unplugged, presented by IMD and hosted by IMD President David Bach and Felix Zeltner. To kick things off, David and Felix discuss the key learnings from David's recent travels that took him from the World Economic Forum to the World Government Summit, to business school conferences in Las Vegas and Lisbon…

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Metabolic mysteries: Hypoglycemia? Don't forget the urine 6:11

4M ago6:11

6:11

Dr Ashlee Stiles discusses the work-up of a 13-month-old girl with hypoglycaemia and discusses the need to balance prompt metabolic work-up with managing the acutely unwell patient in front of you. Critical sample collection is key and don't forget the urine. Read the report here: https://www.sciencedirect.com/science/article/pii/S2214426924000156?…

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Metabolic mysteries: New weakness, poor balance and paresthesia at 55 years of age 7:00

4M ago7:00

7:00

In this Metabolic Mystery, Dr Eamon McCarron unravels an unexpected diagnosis in a 55-year-man with a 2-year history of dragging his legs, poor balance, and paresthesia along the outer aspect of his right thigh. He underwent various assessments and investigations over the next 3 years before a diagnosis was made. https://onlinelibrary.wiley.com/doi…

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Transition & executive function in MSUD 16:30

4M ago16:30

16:30

Dr Jessica Gold discusses observations around executive function in early treated MSUD patients and how this impacts on outcomes around transition to adulthood. Executive and adaptive function impacts long-term outcomes for adults with maple syrup urine diseaseJessica I. Gold, et alhttps://doi.org/10.1002/jimd.12827…

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The future of agritech investing, with Jim Pulcrano & Rob Trice 22:40

5M ago22:40

22:40

Rob Trice is an established international venture capital investor. He is currently leveraging his background in telecom, mobile and internet investing to fund companies that apply IT to the food and agriculture sectors via Better Food Ventures, a seed stage investment entity established in 2013. Jim Pulcrano is Adjunct Professor of Entrepreneurshi…

1
The Trump effect on tech 20:49

5M ago20:49

20:49

Michael Wade is a Professor of Innovation and Strategy and Director of the IMD Global Center for Digital Business Transformation. He also holds the Cisco Chair in Digital Business Transformation. An expert in digital transformation, he has published 10 books and more than 100 case studies, as well as articles on topics such as digital business tran…

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Shortcast: TFP deficiency caused by a deep intronic deletion leading to aberrant splicing 3:05

5M ago3:05

3:05

Dr Thomas Cassini explains how the Undiagnosed Diseases Network group used advanced sequencing techniques to clarify the genotype in a child with an unusual phenotype for mitochondrial trifunctional protein deficiency.Mitochondrial trifunctional protein deficiency caused by a deep intronic deletion leading to aberrant splicingThomas Cassini, et alh…

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CBS Deficiency in the E-HOD Registry 15:58

5M ago15:58

15:58

Dr Andrew Morris joins the podcast to discuss insights from 311 patients with CBS deficiency (classical homocystinuria), their response to treatment and clinical outcomes. Cystathionine β-Synthase Deficiency in the E-HOD Registry—Part II: Dietary and Pharmacological TreatmentAndrew A. M. Morris, Jitka Sokolová, Markéta Pavlíková, Florian Gleich, St…

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Beyond the obvious: quiet predictors of VC fund performance with Michael Kim 36:07

5M ago36:07

36:07

Cendana Capital is a San Francisco-based fund of funds investing in early-stage venture capital ventures. The firm was launched in 2010 and has over $2B in assets. Cendana has invested in many VC teams that have gone on to enjoy great success, like Forerunner Ventures, K9 Ventures, and IA Ventures. In this episode, the founder of Cendana, Michael K…

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Velmanase alfa for alpha-mannosidosis 25:34

6M ago25:34

25:34

Nathalie Guffon joins the podcast to discuss alpha-mannosidosis and the long term efficacy of enzyme replacement therapy with velmanse alfa.Extended long-term efficacy and safety of velmanase alfa treatment up to 12 years in patients with alpha-mannosidosisNathalie Guffon, et alhttps://doi.org/10.1002/jimd.12799…

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The Treatabolome: Don't miss the chance to treat! 22:40

6M ago22:40

22:40

Eva Hoytema van Konijnenburg and Clara van Karnebeek tell the podcast about the treatabolome an epic project to include all current IMD treatments and add them to the IEMbase. The Metabolic Treatabolome and Inborn Errors of Metabolism Knowledgebase therapy tool: Do not miss the opportunity to treat!Bibiche den Hollander, et alhttps://doi.org/10.100…

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Alternative Exit Options for VC Funds, with Liz Campbell 32:32

6M ago32:32

32:32

Liz Campbell, CIO at Portfolio Advisors, discusses the challenges of realising returns in an increasingly sophisticated VC market. Founded in 1994, Portfolio Advisors is an experienced private markets manager with dedicated primary, secondary, co-investment, real estate and direct credit teams. In 2023, Portfolio Advisors combined with FS Investmen…

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The rules of VC, with David Clark CIO at VenCap International 22:20

7M ago22:20

22:20

Since its inception, VenCap has committed $2.9 billion to over 450 venture capital funds in the US, Europe, China and India. As CIO David Clark has decades of experience and access to unparalleled data, and in this episode of Capital Conversations he explores the cycles, metrics and misconceptions associated with VC. *** Through our research, thoug…

1
An update on autophagy disorders 49:08

7M ago49:08

49:08

It seems everyone is talking about autophagy but what is it and what happens when it goes wrong? Hormos Salimi Dafsari, Carlo Dionisi-Vici, and Heinz Jungbluth join the podcast to answer these questions, discuss their experience across 3 (or 2.5) generations of clinical practice and why you never see an obese 100-year-old.An update on autophagy dis…

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Models in Leigh Syndrome 41:32

7M ago41:32

41:32

Marie-Thérèse Henke, Alessandro Prigione, and Markus Schuelke get 2025 off to an informative start discussing why so many models exist for Leigh Syndrome, why we need them and how insights from disease models have led to Sildenafil being used in some patients. Disease models of Leigh syndrome: From yeast to organoidsMarie-Thérèse Henke, Alessandro …