Best Geroscience Podcasts (2025)

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Is Creatine Harming Your Kidneys? The Blood Test Myth Explained. 9:13

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3h ago9:13

9:13

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Many people taking creatine get alarming results on standard kidney function tests, suggesting their kidneys are failing. This video explains why the popular supplement can create a false positive, debunks the myth of kidney damage, …

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Superficial Vein Thrombosis 19:22

2h ago19:22

19:22

Superficial vein thrombosis (SuVT) is characterized by thrombus formation in the superficial veins, typically in the lower or upper extremities. In this podcast, the coauthor of a JAMA review on SuVT, Behnood Bikdeli, MD, MS, discusses pathophysiology, risk factors, diagnosis, and treatment of SuVT with JAMA Deputy Editor Mary McDermott, MD. Relate…

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Elite Performance: How Pro Athletes Use HRV to Train Smarter (Not Harder) 1:38:34

4d ago1:38:34

1:38:34

In this episode, Dr. Matt Kaeberlein sits down with Joel Jamieson to explore the science of heart rate variability and how it connects to longevity, recovery, and performance. Joel shares his journey from training elite fighters to becoming a global authority on HRV training, emphasizing that healthspan is built on consistency, balance, and resilie…

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# 31 He wants to save your pet with cryo - The Kai Micah Mills interview 2:08:54

5d ago2:08:54

2:08:54

When you give a child a pet, you also expose them to death—since most pets pass away long before their owners. But what if we could cryopreserve Buddy or Tiger, and bring them back from suspended animation once we have a cure for what ended their lives? Kai Micah Mills is a pioneering figure in radical life extension and biostasis. As the founder o…

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Magic Mushrooms: The Next Anti-Aging Drug? 32:45

5d ago32:45

32:45

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/A new scientific paper reports that psilocybin, the compound in magic mushrooms, can extend lifespan in mice. A longevity scientist breaks down the data, exploring the study's strengths and weaknesses and discussing the potential bio…

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Diagnosis and Management of Hypothyroidism 13:48

6d ago13:48

13:48

Untreated hypothyroidism can cause serious health complications such as heart failure and myxedema coma. Author Maria Papaleontiou, MD, of the University of Michigan joins JAMA Senior Editor Karen Lasser, MD, MPH, to discuss the current evidence regarding the epidemiology, diagnosis, clinical presentation, and treatment of primary overt hypothyroid…

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A Scientific-Backed Discussion On Fighting Cognitive Decline 1:24:46

7d ago1:24:46

1:24:46

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Today Dr. Kevin White and Erik Nelson join us for a deep-dive conversation as they unveil a new, multi-faceted program designed to halt and even reverse cognitive decline. They break down the key diagnostics, lifestyle pillars, and a…

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From the JAMA Network: Over-the-Counter Hearing Aid–Enabled Earbuds 13:42

10d ago13:42

13:42

Interview with Alexander Chern, MD, author of Over-the-Counter Hearing Aid–Enabled Earbuds—Merging Hearing Health and Technology. Hosted by Paul C. Bryson, MD, MBA. Related Content: Over-the-Counter Hearing Aid–Enabled Earbuds—Merging Hearing Health and Technology

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Debunking 10 Longevity Myths You Still Believe | 126 37:50

12d ago37:50

37:50

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein systematically breaks down ten of the most persistent myths in the health and aging space. From the truth about biological age tests and resveratrol to the real role of genetics and supplements…

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#30 Soon you'll take a drug designed by AI | Alex Zhavoronkov 2:13:52

14d ago2:13:52

2:13:52

As you may have heard, AI-designed medicines have crossed a historic line. In this episode, Alex Zhavoronkov - CEO of Insilico Medicine and founder of ARDD walks us through how Insilico’s rentosertib became the first AI-generated small molecule with peer-reviewed clinical efficacy, while arguing against AI hype and reminding us that biology still m…

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Inside the Offshore Clinics Developing Gene Therapy to Fight Aging | 125 2:00:49

26d ago2:00:49

2:00:49

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Meet the founders (Ivan Morgunov, Anna Vakhrusheva) of Unlimited Bio, a biotech company developing gene therapies in special economic zones, operating outside of traditional FDA regulation. This episode explores their model, the scie…

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Diagnosis and Management of Cutaneous Melanoma 22:49

15d ago22:49

22:49

The incidence and prevalence of cutaneous melanoma in the US and worldwide have increased over the last 5 decades. JAMA Review Author John Kirkwood, MD, discusses the epidemiology, risk factors, treatment, and prevention of melanoma with JAMA Deputy Editor Kristin Walter, MD, MS. Related Content: Cutaneous Melanoma ---------------------------------…

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Testosterone, Rapamycin & Diet Myths: A Scientist's AMA | 124 40:32

28d ago40:32

40:32

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/In this Ask Me Anything episode, longevity scientist Dr. Matt Kaeberlein tackles viewer questions on controversial topics like testosterone therapy and the longevity drug rapamycin. He also offers his science-based perspective on die…

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Diagnosis and Treatment of Hemorrhoidal Disease 18:40

22d ago18:40

18:40

Hemorrhoidal disease, pathology of the tissue lining the anal canal, affects approximately 10 million individuals in the US. Author Jean H. Ashburn, MD, of Wake Forest University School of Medicine and JAMA Senior Editor Karen E. Lasser, MD, MPH, discuss the current evidence on the epidemiology, pathophysiology, diagnosis, and treatment of hemorrho…

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A Geroscience Roundtable: de Grey, Kennedy & Kaeberlein on the Path to Longevity Escape Velocity | 123 1:06:39

1M ago1:06:39

1:06:39

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Join longevity pioneers Dr. Aubrey de Grey, Dr. Brian Kennedy, and Dr. Matt Kaeberlein for a rare, unfiltered discussion on the future of aging. They debate the timeline for longevity escape velocity, the promise of new damage-repair…

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Treatment of Complicated Staphylococcus aureus Bacteremia 11:35

1M ago11:35

11:35

Dalbavancin, a long-acting IV lipoglycopeptide, may be an option for the treatment of complicated Staphylococcus aureus bacteremia without requiring long-term IV access. Author Thomas L. Holland, MD, MSc, from Duke University School of Medicine discusses key points of the DOTS randomized clinical trial and more with JAMA Deputy Editor Preeti Malani…

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Diagnosis and Management of Prostatitis 17:51

1M ago17:51

17:51

Prostatitis affects approximately 9.3% of men in their lifetime and includes acute and chronic bacterial infection and nonbacterial chronic prostatitis with chronic pelvic pain syndrome. Author Minh N. Pham, MD, from University of North Carolina School of Medicine discusses this and more with JAMA Deputy Editor Mary M. McDermott, MD. Related Conten…

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Geroscience in Medicine 16:23

1M ago16:23

16:23

Geroscience aims to define and modify biologic pathways associated with aging and age-related diseases. Author Stephen B. Kritchevsky, PhD, of the Wake Forest University School of Medicine and JAMA Deputy Editor Mary M. McDermott, MD, discuss current evidence regarding geroscience, human health, and promising therapies that may slow aging and age-r…

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Longevity Conference Attendees Hospitalized After Using Peptides? | 122 1:04:05

1M ago1:04:05

1:04:05

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Following a breaking news story about hospitalizations at a longevity conference, scientist Dr. Matt Kaeberlein shares his firsthand experience from the event. He reveals the dangerous mix of legitimate science, unregulated therapies…

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I'm Taking TESTOSTERONE: My Story, Mistakes & Insights From a Longevity Perspective | 120 55:19

2M ago55:19

55:19

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Longevity scientist Dr. Matt Kaeberlein shares his personal and candid journey with testosterone therapy, from initial symptoms and hesitation to the mistakes he made starting out. This conversation breaks down the real-world benefit…

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#29 The Mindset behind longevity & strength at 75 - Natasha Vita-More 1:55:48

2M ago1:55:48

1:55:48

Anyone who is interesed in emerging science and futurism will come across the name Natasha Vita-More; a suggestive name for a charismatic and important philosopher and artist envisioning human possibilities. She wrote the Transhuman Manifesto in 1983. But did you know that she has also made a scientific discovery with big implications for cryoprese…

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Managing Adverse Effects of Obesity Medications 12:21

2M ago12:21

12:21

New medications for obesity, such as semaglutide and tirzepatide, are highly effective but can be associated with adverse effects that reduce adherence. Obesity expert and author Robert Kushner, MD, joins JAMA Deputy Editor Mary McDermott, MD, to discuss a recent JAMA Insights article on managing adverse effects of obesity medications. Related Cont…

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Patent Foramen Ovale-Associated Stroke 20:19

2M ago20:19

20:19

A patent foramen ovale (PFO) is present in approximately 25% of all adults. Author David M. Kent, MD, MS, of Tufts Medical Center and JAMA Associate Editor David Simel, MD, MHS, discuss how to evaluate the likelihood that a PFO was causal in a patient with a cryptogenic ischemic stroke, and closure of a PFO to lower the incidence of recurrent strok…

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Diverticulitis: Diagnosis and Management 15:01

2M ago15:01

15:01

Approximately 200 000 people are hospitalized for diverticulitis each year in the US, and the incidence of diverticulitis is increasing, particularly among younger people. Author Anthony Charles, MD, MPH, of the University of Vermont and JAMA Deputy Editor Mary M. McDermott, MD, discuss current evidence regarding the epidemiology, diagnosis, and tr…

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A Physicist's Radical Theory of Why We Age 1:12:26

2M ago1:12:26

1:12:26

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Physicist Jan Gruber presents a radical theory of aging, describing it as a gradual loss of resilience against random, stochastic events. This new model challenges how we think about biological clocks and could revolutionize the way …

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Ovarian Cancer: Clinical Risk Factors and Treatment 19:23

2M ago19:23

19:23

A recent Review discusses the epidemiology, risk factors, diagnosis, and treatment of ovarian cancer. William Cliby, MD, and John Weroha, MD, PhD, both from the Mayo Clinic in Rochester, Minnesota, discuss this and more with JAMA Associate Editor Margaret Wheeler, MD. Related Content: Ovarian Cancer Endometriosis Typology and Ovarian Cancer Risk Sc…

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Early-Onset Gastrointestinal Cancers 24:58

2M ago24:58

24:58

Early-onset gastrointestinal cancers, typically defined as occurring in patients younger than age 50, are increasing worldwide. A recent JAMA Review summarizes current data on early-onset colorectal, pancreatic, and esophagogastric cancers. Coauthor Kimmie Ng, MD, MPH, of Dana-Farber Cancer Institute joins JAMA Deputy Editor Kristin Walter, MD, MS …

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#28 These rats don't age - here's why | Prof. Rochelle Buffenstein 1:43:04

2M ago1:43:04

1:43:04

Even though it’s undeniably...aesthetic-challenged, the naked mole-rat is the envy of the longevity world. Its risk of death barely changes with time; it shrugs off cancer, stays fertile for decades and seems to skip every hallmark of aging that hobbles the rest of us. But why? What evolutionary forces gave a mouse-sized, subterranean rodent near-i…

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Doctors Reveal Their Blueprint for Lifelong Health (4 Pillars & Key Blood Tests) | 118 1:30:05

2M ago1:30:05

1:30:05

Subscribe to our channel: https://www.youtube.com/@optispanGet Our Newsletter (It's Free): https://www.optispan.life/Dr. Matt sits down with Dr. Nicki Byrne and Dr. Kevin White to break down the four essential pillars for a long and healthy life: eat, move, sleep, and connect. They also reveal the specific blood tests that go beyond a standard chec…

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Managing Lower Urinary Tract Symptoms in Men 16:31

2M ago16:31

16:31

Approximately 40% of men older than 50 have urinary frequency or urgency that affects their quality of life. Author John T. Wei, MD, MS, of the University of Michigan Department of Urology and JAMA Deputy Editor Mary M. McDermott, MD, discuss diagnosis and management of these symptoms in older men. Related Content: Lower Urinary Tract Symptoms in M…

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West Nile Virus 14:28

3M ago14:28

14:28

In the 25 years since its emergence in the US, West Nile virus has become the leading cause of domestic mosquito-borne disease. It causes approximately 1300 neuroinvasive disease cases and 130 deaths annually in the US. Coauthor Carolyn Gould, MD, of the CDC joins JAMA Senior Editor Karen Lasser, MD, to discuss the review on this topic published in…

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Can this 5-day diet rewind your biological age? - A conversation with Andrea Ghirardi 36:40

2M ago36:40

36:40

🎁 Our giveaway is live! 10 winners will receive FMD kits from Prolon. It’s free to enter – just follow the link below 👇 https://gleam.io/NaVa0/prolon-fasting-mimicking-diet-giveaway 🔬 Can food rejuvenate you from within? In this special episode of LEVITY, Peter talks with Andrea Ghirardi, CEO of L-Nutra Europe — the company behind Prolon, the fasti…

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#27 The mind-blowing science to bring you back from death - neuroscientist Ariel Zeleznikow‑Johnston 1:58:31

2M ago1:58:31

1:58:31

When is someone really dead? What does it mean to survive? Is mind-uploading really a possible future way of surviving? These are some of the questions we are discussing with Dr Ariel Zeleznikow-Johnston. Dr Ariel Zeleznikow‑Johnston is a neuroscientist and Research Fellow at Monash University in Melbourne, Australia, whose work delves into the neu…

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Treatment and Management of Osteoporosis 23:05

3M ago23:05

23:05

Worldwide, 1 in 3 women and 1 in 5 men older than 50 years experience osteoporotic fractures in their lifetime. Author Suzanne N. Morin, MD, MSc, of McGill University and JAMA Deputy Editor Mary M. McDermott, MD, discuss the diagnosis and management of osteoporosis. Related Content: Osteoporosis