This Week in Evolution is a podcast on the biology of what makes us tick. Hosts Nels Elde and Vincent Racaniello take you through the new evolution that has been revolutionized by the field of genomics and molecular biology.
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Genotype Podcasts
Stay up to date on novel, clinically-relevant research findings in Parkinson's disease and other movement disorders. Each episode of the International Parkinson and Movement Disorder Society podcast discusses a relevant development in the field, including highlighted journal articles and interviews with the authors.
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The Agri Focus Podcast Series is brought to you by the team in Agriland. In each episode Stella Meehan, joined by an industry expert , takes a closer look at some of the key issues that directly impact on farmers and farming, rural communities and the agricultural sector both in Ireland and beyond.
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Editors at The Lancet Microbe, in conversation with the journal’s authors, explore their latest research and its impact on people’s health, healthcare, and health policy. A monthly audio companion to this open access journal, this podcast covers a broad range of topics, from using probiotics to reduce Staphylococcus aureus, to phage therapy and monitoring antimicrobial resistance using faecal metagenomes, and more.
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Weekly Neurology Deep Dive - A review of recent impactful publications in the field of Neurology
Amer Ghavanini
A selection of recent neurology papers is summarized and discussed, with a focus on review articles and those that have the potential to change clinical practice. Please note that AI has been used in generating the content.
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Monthly discussion of recent publications from the research literature on Alexander Disease, hosted by Albee Messing from the University of Wisconsin-Madison.
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These podcasts are an invaluable resource for anyone interested in child and adolescent mental health. They bridge the gap between rigorous research and practical application, featuring expert discussions on mental health. Each episode highlights cutting-edge studies offering insights into findings, and implications for practice. The series caters to clinicians, researchers, and those interested in mental health. Available on major platforms like Spotify and Apple Podcasts, it’s an accessibl ...
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Every Monday, Antonio and Joe talk about the things that they find interesting from physics, to philosophy, to technology.
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Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.
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This podcast is about personal growth experiences and philosophies. The focus is oriented towards personal transformation of the Psyche and continued introspection.
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Welcome to Nanya’s Dumal(Dumal means thoughts). Here we are going to talk about mental health, experiences, friendship and relationship. We are passionate about sharing as we are passionate about people. Let us all be part of the experience. We would be dropping these episodes every week.
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Do you wish to know issues related to your health and its maintenance? Do you seek clarity in search of healthcare? Do you wish to make safety a top priority? Are you concerned about your health and that of your loved ones? Then this podcast is for you. Our mantra is Health is wealth. This is tied to the fact that health can not be separated from nature, Nuture and Nutrition, hence the name Triple Health. Tune in weekly to listen; subscribe to https://anchor.fm/Amara-Uzodigwe
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234: MTHFR genotype and methionine metabolism predict COVID-19 severity
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20:27️ Episode 234: MTHFR genotype and methionine metabolism predict COVID-19 severity In this episode of PaperCast Base by Base, we explore IMPACC longitudinal metabolomics and genomics analyses show that disruptions in one‑carbon/methionine metabolism together with MTHFR C677T genotype at hospital admission improve prediction of severe COVID‑19 and lo…
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Phenotype-Genotype Correlations in Myelin Protein Zero (MPZ) Variants
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12:47A comprehensive research paper by Laurini et al. (2025) investigating phenotype-genotype correlations in early-onset Charcot-Marie-Tooth type 1B (CMT1B), a neuropathy linked to Myelin Protein Zero (MPZ) variants. The authors analyzed data from a large cohort of 75 Italian patients to understand how different MPZ mutations affect disease severity an…
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240: CYFIP1 controls cortical axon development by modulating calcium
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18:46️ Episode 240: CYFIP1 controls cortical axon development by modulating calcium In this episode of PaperCast Base by Base, we explore Reduction of CYFIP1 delays callosal axon growth and arborization by lowering intracellular calcium and impairing mitochondrial function Study Highlights: In vivo, Cyfip1+/- mice show delayed callosal axon growth at P5…
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239: Genomic Adaptations of the Svalbard Reindeer
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19:21️ Episode 239: Genomic Adaptations of the Svalbard Reindeer In this episode of PaperCast Base by Base, we explore Comparative whole-genome analyses identify 150 differentiated genomic regions and candidate genes linked to fat metabolism, energy conservation, cold tolerance, reduced body size, fur morphology, and circadian rhythm that likely underpi…
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238: Germline polymorphisms shape antibody light chain repertoires
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18:14️ Episode 238: Germline polymorphisms shape antibody light chain repertoires In this episode of PaperCast Base by Base, we explore Long-read sequencing of IGK and IGL paired with AIRR-seq shows that common germline SNVs, SVs, and alleles drive inter-individual differences in light chain gene usage and CDR3 properties Study Highlights: The authors c…
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S6 Ep1: Inside the CAMHS Digital Lab: Apps AI and Young People's Mental Health
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49:16In this episode of Mind the Kids, host Dr. Clara Faria sits down with Dr. Alice Wickersham, Zoe Frith, and Professor Johnny Downs from the CAMHS Digital Lab at King's College London to explore how digital innovation is transforming child and adolescent mental health services. The conversation delves into their groundbreaking work bridging the gap b…
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237: Tracing enteric pathogens in Africa with metagenomics and WGS
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20:00️ Episode 237: Tracing enteric pathogens in Africa with metagenomics and WGS In this episode of PaperCast Base by Base, we explore This study combines whole-genome sequencing and metagenomics to map the diversity, abundance, and genomic relationships of enteric foodborne pathogens across human, animal, food and environmental samples in four African…
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Britt Koskella on bacteriophages as a signature of microbiome health
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26:50Elena Dalla Vecchia of The Lancet Microbe speaks to Dr Britt Koskella about bacteriophages and phageome, their role in modulating the bacteriome, their potential use as signatures of microbiome health and dysbiosis, and hence, indirectly, as markers of host health and disease status. From an ecological perspective, parasites (such as bacteriophages…
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236: XPD translocation and genetic disease etiology
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19:54️ Episode 236: XPD translocation and genetic disease etiology In this episode of PaperCast Base by Base, we explore Computational modeling reveals how ATP-driven conformational cycles of the XPD helicase drive directional 5′→3′ translocation on single-stranded DNA and how mutations disrupt this process to cause disease Study Highlights: The authors…
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Hot Topic: Integrating palliative care into routine care for patients with movement disorders
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15:18Dr. Sarah Camargos continues her conversation on palliative in movement disorders by interviewing Mr. Victor McConvey. Together they discuss the current state of palliative care in movement disorders including current barriers, challenges, and future goals.
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Treating psychiatric comorbidities in patients with epilepsy.
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12:09Patients diagnosed with epilepsy frequently encounter psychiatric and behavioral comorbidities, such as anxiety, depression, and ADHD, at rates significantly higher than the general population. This text outlines the pharmacological management of these conditions, emphasizing that effective seizure control often depends on addressing a patient's ov…
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235: Maternal H3K9 methyltransferases control aRMAE in C. elegans
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17:56️ Episode 235: Maternal H3K9 methyltransferases control aRMAE in C. elegans In this episode of PaperCast Base by Base, we explore Using dual-color reporters in C. elegans, the study shows maternal H3K9 methyltransferases MET-2 and SET-25 antagonistically regulate autosomal random monoallelic expression initiated in the early embryo Study Highlights…
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The prognosis and treatment outcomes for individuals with focal epilepsy
14:30
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14:30This review explores the prognosis and treatment outcomes for individuals with focal epilepsy, a common neurological condition where seizures originate in specific brain regions. While roughly two-thirds of patients achieve seizure freedom using anti-seizure medications (ASMs), approximately one-third develop drug-resistant epilepsy (DRE). The auth…
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Global surge of early-onset Parkinson’s disease (EOPD)
11:27
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11:27This research analyzes the global surge of early-onset Parkinson’s disease (EOPD) between 1990 and 2021, revealing that incidence and prevalence rates have nearly tripled worldwide. The study highlights a disproportionately high burden in Latin American countries, likely driven by specific genetic mutations and environmental factors such as arsenic…
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New-onset refractory status epilepticus (NORSE) and febrile infection-related epilepsy syndrome (FIRES)
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13:23New-onset refractory status epilepticus (NORSE) and its subcategory, febrile infection-related epilepsy syndrome (FIRES), are rare clinical presentations characterized by the sudden onset of drug-resistant seizures in individuals without prior epilepsy. These conditions typically follow a biphasic course, beginning with a catastrophic acute phase o…
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233: Mechanistic basis of NuA3 recognition and H3K14 acetylation
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18:48️ Episode 233: Mechanistic basis of NuA3 recognition and H3K14 acetylation In this episode of PaperCast Base by Base, we explore Cryo-EM structures of the yeast NuA3 complex reveal how a cooperative Sas3–Nto1 binding cleft recognizes the H3 tail and directs acetylation of H3K14 Study Highlights: The authors report cryo-EM structures of NuA3 in apo,…
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232: Lamin A/C steers fork restart via H3K9me3 and PARylation
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17:58️Episode 232: Lamin A/C steers fork restart via H3K9me3 and PARylation In this episode of PaperCast Base by Base, we explore Nucleoplasmic Lamin A/C, together with LAP2α, enforces active replication fork slowing during mild replication stress by promoting local H3K9me3 and ADP-ribosylation to restrain RECQ1-mediated restart and protect genome stabi…
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231: Transcription start sites as a germline mutational hotspot
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17:01️Episode 231: Transcription start sites as a germline mutational hotspot In this episode of PaperCast Base by Base, we explore This study identifies a pronounced germline mutational hotspot centered on transcription start sites (TSSs) driven in part by early embryonic mosaic variants and transcription-associated DNA damage Study Highlights: Extreme…
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S5 Ep8: Mind the Kids - Therapy and Autism: Actions for Adaptions
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48:14This Mind the Kids episode, ‘Therapy and Autism: Actions for Adaptations’, asks what does truly neurodiversity affirming therapy look like for autistic young people with co occurring mental health difficulties? Dr Jane Gilmour and Professor Umar Toseeb are joined by clinician researcher Professor Francisco Musich to step inside the therapy room and…
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230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome
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18:27️Episode 230: MIDEAS Y654S hyperactivates MiDAC in a dominant neurodevelopmental syndrome In this episode of PaperCast Base by Base, we explore A recurrent de novo MIDEAS p.Tyr654Ser variant disrupts an autoinhibitory loop in the MiDAC complex, increasing HDAC1 deacetylase activity and causing a multisystem neurodevelopmental disorder Study Highlig…
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Live from the European Parliament in Strasbourg, MEP Ciaran Mullooly speaks to AgriFocus about the momentum that is building this week in opposition to the EU Mercosur trade deal in its current form.By Agriland
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229: Inhibiting PCBP2 condensates in Alzheimer’s
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19:55
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19:55️Episode 229: Inhibiting PCBP2 condensates in Alzheimer’s In this episode of PaperCast Base by Base, we explore Elevated PCBP2 forms liquid-like condensates that sequester mitochondrial and RNA-binding proteins, stabilize BACE1 mRNA, and promote amyloid pathology while the small molecule CN-0928 reduces PCBP2 via INTS1 to lower Aβ and improve cogni…
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Waveform-based analysis of head tremor using a marker-less tracking algorithm with 2D-video
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23:08Differentiating a dystonic head tremor from a head tremor in essential tremor can sometimes be diagnostically challenging. In this episode, Dr. Mitra Afshari interviews Dr. Jung Hwan Shin and Prof. Beomseok Jeon on their investigation into the rhythmicity and sinusoidality of head tremors in cervical dystonia versus essential tremor using simple 2D…
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Long-term outcomes of seizures and epilepsy in patients with untreated cerebral cavernous malformations
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11:30This prospective, population-based cohort study focuses on the long-term outcomes of seizures and epilepsy in patients with untreated cerebral cavernous malformations (CCMs). The research tracked 300 patients in Scotland for a median of 15 years to assess the risk of developing seizures and experiencing seizure recurrence without surgical intervent…
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228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity
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18:02️ Episode 228: Two non-competing H3N2 stem antibodies reveal evolving antigenicity In this episode of PaperCast Base by Base, we explore Structural and functional characterization of two group 2 H3 HA stem antibodies, 2F02 and AG2-G02, shows distinct non-overlapping epitopes, protection in mice, and antigenic changes driven by HA2 position 32 that …
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Cardiac Involvement in Myotonic Dystrophy Type 1 and 2
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10:43This article focuses on the risk of cardiac disease in a population cohort of individuals with Myotonic Dystrophy Type 1 (DM1) and Type 2 (DM2). This study, conducted by Nicholas E. Johnson et al. using data from the Muscular Dystrophy Surveillance, Tracking, and Research Network (MD STARnet), investigated the frequencies of cardiac arrhythmias and…
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227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation
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16:21
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16:21️ Episode 227: 1q gain enables rescue of aneuploid hESCs during RPE differentiation In this episode of PaperCast Base by Base, we explore This study shows that spontaneous RPE differentiation eliminates most aneuploid human pluripotent stem cells but permits expansion of cells with chromosome 1q gains when they are co-cultured with wild-type cells …
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226: FGF4 protects podocytes in diabetic kidney disease
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16:09️ Episode 226: FGF4 protects podocytes in diabetic kidney disease In this episode of PaperCast Base by Base, we explore This study shows that podocyte-derived FGF4 is reduced in DKD and that recombinant FGF4 preserves podocyte survival and glomerular function in diabetic models via FGFR1-AMPK-FOXO1 signaling Study Highlights: FGF4 expression is dow…
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225: VRK-1 and BAF-1 release meiotic chromosomes
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17:13️ Episode 225: VRK-1 and BAF-1 release meiotic chromosomes In this episode of PaperCast Base by Base, we explore VRK-1 phosphorylates BAF-1 to remove chromatin from the nuclear periphery during early meiotic prophase in C. elegans, and failure of this step impairs pairing and synapsis and generates heritable genome lesions Study Highlights: The aut…
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224: AntennAlive — wireless in-body sensing with engineered bacteria
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18:41️ Episode 224: AntennAlive — wireless in-body sensing with engineered bacteria In this episode of PaperCast Base by Base, we explore A bio-hybrid, battery-free implant converts engineered bacterial activity into microwave backscatter signals by controlled degradation of a biodegradable antenna Study Highlights: The AntennAlive system uses a magnesi…
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S4 Ep4: Mind the Kids - The Lowdown on Meltdowns
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48:05
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48:05What actually is a ‘meltdown’, and when do big feelings in kids become a problem that families and schools can’t ignore? In this episode of Mind the Kids, hosts Dr. Jane Gilmour and Professor Umar Toseeb sit down with Associate Professor Erin Gonzalez from the University of Washington School of Medicine, to unpack meltdowns in real-life, everyday l…
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223: Torsion Regulates DNA Replication Stalling and Restart
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16:26️ Episode 223: Torsion Regulates DNA Replication Stalling and Restart In this episode of PaperCast Base by Base, we explore New single-molecule angular optical trap assays reveal that DNA torsion directly controls T7 replisome stalling and reactivation Study Highlights: A high-resolution, label-free angular optical trap (AOT) assay was developed to…
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222: snaR-A hijacks splicing to drive proliferation
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17:57️ Episode 222: snaR-A hijacks splicing to drive proliferation In this episode of PaperCast Base by Base, we explore This episode examines how the cancer-associated Pol III transcript snaR-A binds core splicing factors, localizes near nuclear speckles, perturbs U2-dependent splicing to increase intron retention, and promotes cell proliferation linke…
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Collegiality and friendship - MDS 40th Anniversary
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16:19
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16:19To celebrate the 40th Anniversay of the MDS, Dr. Michele Matarazzo sits down with two key leaders of the MDS Asian Oceanian section, Prof. Carolyn Sue and Prof. Beomseok Jeon. Together they discuss the early years of movement disorder “rock stars”, how the society has changed through their eyes, and impacts it has had on their careers.…
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A lifetime of experiences and learnings - MDS 40th Anniversary
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20:32To celebrate the 40th Anniversary of the MDS, Dr. Michele Matarazzo sits down with two key leaders of the MDS Pan-American section, Dr. Cynthia Comella and Dr. Oscar Gershanik. Together they discuss how they got involved in the society, what they are most proud of, and what the Society means to them, both professionally and personally.…
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Rituximab Therapy for Resistant Myasthenia Gravis
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10:24The paper presents a single-center prospective cohort study from Latvia examining the use of the anti-CD20 monoclonal antibody, rituximab, as a treatment for refractory myasthenia gravis (MG). Conducted on nine patients who had failed conventional treatments, the study evaluated the effects of a single low dose over a six-month period. Results indi…
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221: Allele-resolved nanopore tour of the human placental methylome
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20:23️ Episode 221: Allele-resolved nanopore tour of the human placental methylome In this episode of PaperCast Base by Base, we explore Using phased long-read nanopore and short-read sequencing across eight trios, the study maps allele-specific DNA methylation and transcription in female human placentas, identifies hundreds of DMRs and novel imprinted …
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220: The AML cellular state space reveals NPM1 immune evasion subtypes
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15:48️Episode 220: The AML cellular state space reveals NPM1 immune evasion subtypes In this episode of PaperCast Base by Base, we explore Single-cell and bulk sequencing of 120 AML cases reveal two NPM1-mutated subtypes with distinct immune evasion mechanisms and divergent responses to hematopoietic stem cell transplantation Study Highlights: Bulk RNA-…
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219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain
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16:41️Episode 219: Multi-omic mapping of lipid dysregulation in Parkinson’s brain In this episode of PaperCast Base by Base, we explore Targeted multi-region lipidomics with proteomic and mitochondrial data reveals region- and stage-specific lipid alterations in Parkinson’s disease that converge on mitochondrial dysfunction Study Highlights: The study q…
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218: SIM1 and the multi-ancestry genomics of erectile dysfunction
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19:37️Episode 218: SIM1 and the multi-ancestry genomics of erectile dysfunction In this episode of PaperCast Base by Base, we explore A large multi-ancestry GWAS meta-analysis identifies a dominant SIM1-linked locus and multiple genetic connections between electronic health record-defined erectile dysfunction and cardiometabolic, psychiatric, and substa…
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S4 Ep6: Mind the Kids - Mental Health Needs in Care, but Missed Out
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41:07‘Mental Health Needs in Care, but Missed Out’ takes listeners inside the realities and challenges faced by children in the UK care system. This episode brings real human stories and statistics together, highlighting that care experiences are diverse and often compounded by instability, repeated moves, and separation from familiar environments. The …
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217: Multiscale triads of meiotic crossover patterning
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17:47️Episode 217: Multiscale triads of meiotic crossover patterning In this episode of PaperCast Base by Base, we explore FFT and inverse-FFT analysis of Zip3/Zip2, Hop1 and Zip1 on yeast pachytene chromosomes reveals two interdigitated tiers of evenly spaced protein triads that correspond to canonical and minority crossovers and are differentially reg…
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Everything you need to know about bluetongue
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25:51Over the past week Agriland reported on the news that there was a suspected bluetongue case reported on a farm near Bangor, Co. Down in Northern Ireland. Results from the Department of Agriculture, Environment and Rural Affairs (DAERA) active surveillance for bluetongue indicated the presence of the disease in two cows. As a result they have activa…
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216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair
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18:27️ Episode 216: 53BP1-RIF1 and DNA-PKcs: distinct interactions in chromosomal break repair In this episode of PaperCast Base by Base, we explore This episode reviews a study showing that 53BP1-RIF1 and DNA-PKcs have different genetic relationships across blunt end joining, deletion patterns, HDR, and radiosensitivity Study Highlights: Using EJ7-GFP …
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215: Protein Set Transformer for high-diversity viromics
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20:07️ Episode 215: Protein Set Transformer for high-diversity viromics In this episode of PaperCast Base by Base, we explore Protein Set Transformer (PST) is a protein-based genome language model that represents genomes as sets of proteins to improve genome and protein representations across diverse viral datasets Study Highlights: PST embeds proteins …
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The lasting impacts of scholarly debates - MDS 40th Anniversary
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15:06To celebrate the 40th Anniversay of the MDS, Dr. Sara Schaefer sits down with two key leaders of the MDS European Regional Section, Prof. Marie Vidailhet and Prof. Alberto Albanese. Listen as they share their fond memories of scholarly debate, Congress experiences, and hopes for the future.
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Promoting diversity and access to care and education - MDS 40th Anniversary
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21:49To celebrate the 40th Anniversay of the MDS, Dr. Sara Schaefer sits down with two key leaders of the MDS African Regional section, Dr. Njideka Okubadejo and Dr. Jonathan Carr. Together they discuss their experiences within MDS and what makes them proud to be long-standing members.
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Advances in Treatment of Myasthenia Gravis
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16:13This neurological update details the substantial advancements in treating Myasthenia Gravis (MG), emphasizing transformative developments since 2016. A major focus is the proven efficacy of thymectomy in non-thymomatous disease and the introduction of novel targeted immunotherapies, including complement inhibitors and FcRN inhibitors that actively …
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214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion
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18:21️ Episode 214: PI(4,5)P2 Asymmetry Enables Rapid FGF2 Secretion In this episode of PaperCast Base by Base, we explore This study shows that an asymmetric transbilayer distribution of PI(4,5)P2 lowers the energy barrier for lipidic pore formation and accelerates unconventional secretion of Fibroblast Growth Factor 2 Study Highlights: The authors gen…
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213: BRAIN-MAGNET: a functional atlas for non-coding variants
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20:29️ Episode 213: BRAIN-MAGNET: a functional atlas for non-coding variants In this episode of PaperCast Base by Base, we explore BRAIN-MAGNET couples a ChIP-STARR-seq atlas of 148,198 neural regulatory elements with a validated convolutional neural network to predict enhancer activity and prioritize disease-relevant non-coding variants Study Highlight…
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