Best Functioning Tumor Podcasts (2025)

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133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth 24:31

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18h ago24:31

24:31

️ Episode 133: Culture-Independent Meta‑Pangenomics Reveals Gut Genome Links to Child Growth In this episode of PaperCast Base by Base, we explore how long‑read metagenomics enables recovery of complete metagenome‑assembled genomes directly from fecal samples of Malawian toddlers and applies meta‑pangenomics and microbial GWAS to connect microbial …

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132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer 20:35

2d ago20:35

20:35

️ Episode 132: Tumor transcriptome classifiers predict treatment sensitivity in advanced prostate cancer In this episode of PaperCast Base by Base, we explore how transcriptome-wide RNA expression classifiers from advanced prostate cancers can inform treatment selection and improve patient outcomes. Study Highlights: Researchers analyzed tumor tran…

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Mortality Awareness: Meaning, Motivation, and Your To-Die-For Life with Karen Salmansohn 1:01:27

2d ago1:01:27

1:01:27

Delanie Fischer is joined by Behavioral Change Expert and Bestselling Author, Karen Salmansohn, to discuss insights from her latest book, Your To-Die-For Life: How to Maximize Joy and Minimize Regret . . . Before Your Time Runs Out. Karen combines neuroscience, psychology, philosophy, and personal stories to share effective mindset hacks, exercises…

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131: pBI143: The Human Gut’s Hidden Heavyweight 17:59

3d ago17:59

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️ Episode 131: pBI143: The Human Gut’s Hidden Heavyweight In this episode of PaperCast Base by Base, we explore how a tiny 2.7 kb cryptic plasmid, pBI143, emerges as one of the most numerous genetic elements in industrialized human gut microbiomes, mobilizes across Bacteroidales, persists as monoclonal lineages with vertical transmission, and incre…

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Tumoroid-on-a-Chip as a Physiologically Relevant Model for Immunotherapy 1:02:48

1d ago1:02:48

1:02:48

Explore the cutting-edge integration of organoid technology and microfluidic systems in this exclusive webinar by Creative Biolabs. Discover how Tumoroid-on-a-Chip platforms revolutionize preclinical immunotherapy research. *Key Learning Points:* 🔬 Principles of 3D Tumoroid-on-a-Chip technology ⚙ Microphysiological system design for immune-tumor in…

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The Double-Edged Role of Extracellular Vesicles in Alzheimer's Disease 1:01:08

1d ago1:01:08

1:01:08

In this webinar, we explore the emerging role of extracellular vesicles (EVs) and exosomes in Alzheimer’s disease (AD), focusing on their potential as biomarkers for early diagnosis and novel therapeutic targets. Key topics include: The biology of EVs in neurodegenerative diseases Advances in EV-based biomarker discovery for AD Therapeutic applicat…

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130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution 20:24

4d ago20:24

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️ Episode 130: Combining Evidence from Human Genetic and Functional Screens to Identify Pathways Altering Obesity and Fat Distribution In this episode of PaperCast Base by Base, we explore a large-scale study that integrates genetic association testing with functional CRISPR experiments in human adipocytes to uncover mechanisms influencing obesity …

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129: Structural variation and diversification of the NPIP gene family from the human pangenome 22:11

5d ago22:11

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️ Episode 129: Structural variation and diversification of the NPIP gene family from the human pangenome In this episode of PaperCast Base by Base, we explore how long-read sequencing technologies reveal the structural variation, evolutionary pressures, and expression patterns of the NPIP gene family, one of the most positively selected gene famili…

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128: LINE‑1 Promoters Orchestrate Early Human Brain Development 15:26

6d ago15:26

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️ Episode 128: LINE‑1 Promoters Orchestrate Early Human Brain Development In this episode of PaperCast Base by Base, we explore how evolutionarily young LINE‑1 retrotransposons are actively expressed in human induced pluripotent stem cells and function as cis‑acting promoters that shape primate‑ and human‑specific transcript isoforms during early n…

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127: In silico generation of synthetic cancer genomes using generative AI 17:36

7d ago17:36

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️ Episode 127: In silico generation of synthetic cancer genomes using generative AI In this episode of PaperCast Base by Base, we explore OncoGAN, a generative AI pipeline designed to produce highly realistic synthetic cancer genomes. The study addresses the challenge of limited access to real cancer genomes due to privacy concerns by creating shar…

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126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models 20:59

8d ago20:59

20:59

️ Episode 126: Molecular and developmental deficits in Smith-Magenis syndrome human stem cell-derived cortical neural models In this episode of PaperCast Base by Base, we explore a study that investigates the molecular and developmental mechanisms underlying Smith-Magenis syndrome (SMS) using human induced pluripotent stem cell (hiPSC)-derived cort…

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125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities 22:46

9d ago22:46

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️ Episode 125: Tackling a disease on a global scale, the Global Parkinson’s Genetics Program, GP2: A new generation of opportunities In this episode of PaperCast Base by Base, we explore how the Global Parkinson’s Genetics Program (GP2) is addressing the critical lack of diversity in Parkinson’s disease genetics research. The article outlines the p…

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“You’re So Sensitive”: Understanding Everyday Microaggressions, Implicit Bias, and Best Practices with Billie Lee & Dr. Gina Torino 45:19

10d ago45:19

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Delanie Fischer is joined by Billie Lee—comedian, activist, and the first openly transgender cast member on BravoTV’s Vanderpump Rules—and Dr. Gina Torino, psychologist and microaggression expert, to share insights from their book, Why Are You So Sensitive?: Navigating Everyday, Unintended Microaggressions. They discuss why microaggressions aren’t …

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124: Exploring the Omnigenic Architecture of Selected Complex Traits 23:47

10d ago23:47

23:47

️ Episode 124: Exploring the Omnigenic Architecture of Selected Complex Traits In this episode of PaperCast Base by Base, we explore how researchers are uncovering the organizational principles behind complex traits through the lens of the omnigenic model. The study focuses on ulcerative colitis as a case example and investigates how core and perip…

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123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease 18:12

11d ago18:12

18:12

️ Episode 123: Dominant‑Negative ATP5F1A Variants Uncouple Complex V and Drive Neurological Disease In this episode of PaperCast Base by Base, we explore how de novo heterozygous ATP5F1A missense variants disrupt mitochondrial ATP synthase and manifest as pediatric neurological disorders, revealing a dominant‑negative mechanism and an isolated Comp…

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122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences 19:57

12d ago19:57

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️ Episode 122: Patient Stratification Reveals the Molecular Basis of Disease Co-Occurrences In this episode of PaperCast Base by Base, we explore a study that investigates the molecular underpinnings of why certain diseases tend to co-occur. By using large-scale RNA sequencing data, the authors present a novel approach to identify disease co-occurr…

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121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma 19:02

13d ago19:02

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️ Episode 121: G-quadruplexes as a Source of Vulnerability in BRCA2-deficient Granule Cell Progenitors and Medulloblastoma In this episode of PaperCast Base by Base, we explore how DNA secondary structures called G-quadruplexes (G4s) contribute to genome instability and tumor development in BRCA2-deficient cerebellar granule cell progenitors, leadi…

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120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment 22:30

14d ago22:30

22:30

️Episode 120: Rare BMAL1 Variants Link the Circadian Clock to Neurodevelopment In this episode of PaperCast Base by Base, we explore how ultrarare heterozygous variants in BMAL1—a core circadian clock gene—are associated with a neurodevelopmental syndrome featuring developmental delay, autism spectrum disorder, and musculoskeletal findings. Study H…

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119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells 18:35

15d ago18:35

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️ Episode 119: G‑Quadruplex Stabilization Triggers Pericentromeric DNA Breaks in B Cells In this episode of PaperCast Base by Base, we explore how stabilizing G‑quadruplex DNA structures with small molecules reshapes genome stability in B lymphocytes, revealing fragile hotspots in pericentromeric repeats and ribosomal DNA and exposing checkpoint-de…

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The Science Behind Humanized Mouse Models 8:15

15d ago8:15

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This video by Creative Biolabs, tailored for biological researchers, delivers a conversational overview of the science behind humanized mouse models—covering their definition, classification, construction strategies, core applications (drug screening, drug metabolism and toxicity assessment, personalized therapy), success cases in tumor immunothera…

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118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B 19:11

16d ago19:11

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️ Episode 118: Cancer cells subvert the primate-specific KRAB zinc finger protein ZNF93 to control APOBEC3B In this episode of PaperCast Base by Base, we explore how cancer cells co-opt a primate-specific KRAB zinc finger protein, ZNF93, to fine-tune the mutagenic enzyme APOBEC3B and manage replication stress. Study Highlights: Using genome-wide KZ…

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Release Your Perfectionism Handbrake: Power Planning, Clean Rest, and Demystifying Procrastination with Sam Laura Brown 1:11:11

17d ago1:11:11

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Delanie Fischer is joined by Sam Laura Brown, host of The Perfectionism Project and Founder of Perfectionists Getting Shit Done, to discuss how to approach your personal and professional goals in a way that works with your brain, not against it. Sam shares insights on Power Planning, the importance of clean rest, and an astounding reason why we pro…

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117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection 16:00

17d ago16:00

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️ Episode 117: Pol III–linked polyadenylation fuels SINE RNA accumulation during infection In this episode of PaperCast Base by Base, we explore how viral infection couples RNA polymerase III transcription with mRNA-like 3′ end processing to stabilize noncoding retrotransposon RNAs, revealing a conserved mechanism that boosts SINE RNA abundance dur…

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116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation 15:53

17d ago15:53

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️ Episode 116: Cell Type–Specific Purifying Selection of Synonymous mtDNA Variation In this episode of PaperCast Base by Base, we explore how a seemingly “silent” synonymous mitochondrial DNA mutation can shape immune cell fitness, revealing cell type–specific selection in human T cells and a mechanistic link to mitochondrial translation dynamics. …

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115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System 15:24

17d ago15:24

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Episode 115: A Transcriptomic, Proteomic, and Functional Genetic Atlas Dissects Neurofibromin Function in the Peripheral Nervous System In this episode of PaperCast Base by Base, we explore how an integrated multi‑omics and CRISPR interference atlas maps the function of the NF1 tumor suppressor neurofibromin in peripheral nerve cells and reveals co…

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114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique 16:31

20d ago16:31

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️ Episode 114: One-hour extraction-free loop-mediated isothermal amplification HPV DNA assay for point-of-care testing in Maputo, Mozambique In this episode of PaperCast Base by Base, we explore the development of a rapid and affordable HPV DNA test designed for cervical cancer screening in low-resource settings. The study introduces a one-hour, ex…

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113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations 22:08

21d ago22:08

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️ Episode 113: Joint, Multifaceted Genomic Analysis Enables Diagnosis of Ultra-Rare Monogenic Presentations In this episode of PaperCast Base by Base, we explore how the Undiagnosed Diseases Network (UDN) applied whole‑genome sequencing and new, well‑calibrated statistics to jointly analyze diverse, ultra‑rare monogenic cases across the consortium,…

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112: Local Genetic Sex Differences in Quantitative Traits 21:16

22d ago21:16

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️ Episode 112: Local Genetic Sex Differences in Quantitative Traits In this episode of PaperCast Base by Base, we explore how genetic differences between males and females are distributed across the genome, moving beyond global averages of heritability and correlation. The study introduces a fine-scale approach using LAVA to examine local genetic s…

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111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer 17:06

23d ago17:06

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️ Episode 111: A Multimodal Dataset for Precision Oncology in Head and Neck Cancer In this episode of PaperCast Base by Base, we explore the creation of HANCOCK, a comprehensive multimodal dataset designed to advance precision oncology in head and neck cancer. The study addresses the urgent need for large, publicly available datasets to improve bio…

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The Psychology of Infidelity: Why People Cheat, Non-Monogamy vs. Monogamy, and Sexual Mindfulness with Dr. Tara 54:37

23d ago54:37

54:37

Delanie Fischer is joined by Dr. Tara—Tenured Professor of Relational and Sexual Communication and Quantitative Research at California State University Fullerton, TV Sexpert on Celebs Go Dating, and Co-Host of the iconic radio show Loveline—to unpack the “whys” behind infidelity. Dr. Tara shares the 3 main reasons people cheat, how to begin healing…

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110: Whole-exome sequencing identifies new schizophrenia risk genes 20:31

23d ago20:31

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️ Episode 110: Whole-exome sequencing identifies new schizophrenia risk genes In this episode of PaperCast Base by Base, we explore a landmark whole-exome sequencing study that expands our understanding of the rare genetic variants contributing to schizophrenia risk. By combining newly sequenced samples with large-scale published datasets, research…

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109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality 18:10

25d ago18:10

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️ Episode 109: Autocrine Interferon Poisoning: ADAR1–BRCA Synthetic Lethality In this episode of PaperCast Base by Base, we explore how loss of the RNA editor ADAR1 becomes lethal to BRCA1/2‑mutant cancer cells through a tumor‑cell‑autonomous interferon response, outlining a biomarker‑guided path to ADAR1‑targeted therapy. Study Highlights: A focus…

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108: Epigenome Editing Reverses HBG Silencing 20:53

26d ago20:53

20:53

️ Episode 108: Epigenome Editing Reverses HBG Silencing In this episode of PaperCast Base by Base, we explore how targeted removal of CpG methylation at the HBG promoters causally reactivates fetal hemoglobin (HbF) without cutting DNA, revealing a precise path to treat β‑hemoglobinopathies. Study Highlights: A forward CRISPR screen in adult‑type er…

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107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases 19:07

27d ago19:07

19:07

Episode 107: Genome-wide Association Study Reveals Genetic Links to Pulpal and Apical Diseases In this episode of PaperCast Base by Base, we explore a large-scale genome-wide association study investigating the genetic underpinnings of pulpal and apical diseases. Using Finnish health registry data from over 485,000 individuals in the FinnGen cohort…

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106: Decoding Brain Maps for Pharmacotranscriptomics 19:25

28d ago19:25

19:25

️ Episode 106: Decoding Brain Maps for Pharmacotranscriptomics In this episode of PaperCast Base by Base, we explore a Nature Communications study, that introduces a fast, surface-based framework to decode imaging-derived brain phenotypes by aligning high-resolution cortical gene-expression maps with PET targets and structural MRI patterns. The wor…

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105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance 18:28

29d ago18:28

18:28

️ Episode 105: Genome-level Selection as a Universal Marker of Cancer Therapy Resistance In this episode of PaperCast Base by Base, we explore groundbreaking research revealing how the evolutionary dynamics of tumor genomes can serve as a universal marker of resistance to cancer therapy. By analyzing whole-exome sequencing data from multiple cancer…

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104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation 16:56

30d ago16:56

16:56

Episode 104: Cross-population GWAS and proteomics improve risk prediction and reveal mechanisms in atrial fibrillation In this episode of PaperCast Base by Base, we explore a large cross-ancestry study that integrates genome-wide association results with plasma proteomics to map genetic architecture, nominate causal pathways and proteins, and boost…

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What's The Deal with Astrology? 12 Archetypes and Your Cosmic Zone with Madi Murphy 1:08:11

1M ago1:08:11

1:08:11

Delanie Fischer is joined by Astrologer Madi Murphy, Founder of CosmicRX and Author of In the Cosmic Zone: Embody the 12 Astro Archetypes to Unleash Your Genius and Activate Your Authentic Self, to discuss all things astrology—history, skepticism, archetypes, planetary transits, and leveraging your unique natal chart to create a life that feels lik…

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103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery 17:56

1M ago17:56

17:56

️ Episode 103: Genome Sequencing Forecasts Outcomes After Congenital Cardiac Surgery In this episode of PaperCast Base by Base, we explore how large-scale exome sequencing combined with explainable AI can predict adverse outcomes after surgery for congenital heart defects. Using a prospective cohort from the Pediatric Cardiac Genomics Consortium, t…

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102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort 14:38

1M ago14:38

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Episode 102: Clinical Impact of Pharmacogenetic Risk Variants in a Large Chinese Cohort In this episode of PaperCast Base by Base, we explore how large-scale pharmacogenomics translates to real-world care using data from the Taiwan Precision Medicine Initiative. We follow a Nature Communications study that analyzes gene–drug interactions across 486…

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101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis 18:25

1M ago18:25

18:25

️Episode 101: JAK2 Inhibition Selects RAS-Mutant Clones in Myelofibrosis In this episode of PaperCast Base by Base, we explore how JAK2 inhibition with ruxolitinib can reshape clonal architecture in myeloproliferative neoplasms (MPN), favoring outgrowth of RAS‑pathway mutant subclones and altering patient outcomes. We situate these findings within …

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️ 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia 14:44

1M ago14:44

14:44

️ Episode 100: Epigenomic Diagnosis and Prognosis of Acute Myeloid Leukemia In this episode of PaperCast Base by Base, we explore a groundbreaking study that maps the epigenomic landscape of Acute Myeloid Leukemia (AML) and develops powerful diagnostic and prognostic tools for clinical use. The research introduces the Acute Leukemia Methylome Atlas…

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️ 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis 14:36

1M ago14:36

14:36

️ Episode 99: NXT2: A Testis-Specific RNA Export Factor Essential for Spermatogenesis In this episode of PaperCast Base by Base, we explore how the testis-enriched paralog NXT2 orchestrates nucleocytoplasmic mRNA export in human germ cells and its critical role in male infertility. Study Highlights: Proteomic analyses of human testicular tissue unc…

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️ 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease 19:20

1M ago19:20

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️ Episode 98: Cell Marker Accordion: Interpretable Single-Cell and Spatial Omics Annotation in Health and Disease In this episode of PaperCast Base by Base, we explore a user-friendly platform developed by Busarello et al. that integrates and standardizes over 23 human and murine gene-marker databases into a weighted resource for robust annotation …

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️ 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial 21:43

1M ago21:43

21:43

️ Episode 97: Pancreatic Cancer Genomics: Insights from the COMPASS Trial In this episode of PaperCast Base by Base, we explore how integrated whole genome and transcriptome sequencing uncovers clinically relevant subtypes and molecular features in advanced pancreatic ductal adenocarcinoma (PDAC). Study Highlights: The COMPASS trial profiled 268 ad…

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️ 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease 16:39

1M ago16:39

16:39

️ Episode 96: Early Cerebrospinal Fluid Proteomic Changes in Down Syndrome and Alzheimer’s Disease In this episode of PaperCast Base by Base, we explore a large-scale proteomic study comparing cerebrospinal fluid (CSF) profiles in individuals with Down Syndrome (DS), late-onset Alzheimer’s disease (LOAD), and autosomal dominant Alzheimer’s disease …

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Meeting Your Soulmate (While Married) and Breaking Free From "Good Girl" Conditioning with Amber Rae 58:37

1M ago58:37

58:37

Delanie Fischer is joined by Amber Rae, author of Loveable, to unpack what it was like to meet her soulmate—while still married to her ex-husband. Amber shares her feelings about experiencing a lonely marriage, the days leading up to her decision to leave, how she transformed internalized shame, where she and her ex-husband are now in life and love…

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️ 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation 19:10

1M ago19:10

19:10

️ Episode 95: Mitochondria on the Move: Biotechnological Strategies for Transfer and Transplantation In this episode of PaperCast Base by Base, we explore recent advances in biotechnological methods for mitochondria transfer and transplantation aimed at restoring cellular function in diseases driven by mitochondrial dysfunction. Study Highlights: T…

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️ 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer 20:29

1M ago20:29

20:29

️ Episode 94: Intraindividual Epigenetic Heterogeneity in Advanced Prostate Cancer In this episode of PaperCast Base by Base, we explore how integrated DNA methylation, RNA sequencing, and histone modification profiling across metastatic lesions reveal intraindividual epigenetic diversity underlying phenotypic subtypes of castration-resistant prost…

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️ 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13 19:01

1M ago19:01

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️ Episode 93: Neuroinvasive and Pulmonary Virulence of H5N1 Clade 2.3.4.4b Genotype B3.13 In this episode of PaperCast Base by Base, we explore how a bovine-derived H5N1 virus from clade 2.3.4.4b genotype B3.13 exhibits enhanced pulmonary and neurovirulent properties in mouse models, highlighting its potential implications for zoonotic transmission…