Base by Base explores advances in genetics and genomics, with a focus on gene-disease associations, variant interpretation, protein structure, and insights from exome and genome sequencing. Each episode breaks down key studies and their clinical relevance—one base at a time. Powered by AI, Base by Base offers a new way to learn on the go. Special thanks to authors who publish under CC BY 4.0, making open-access science faster to share and easier to explore.
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Coin Base Podcasts
Crypto Current is a podcast where Srijan Bharadwaj breaks down the complex subject of cryptocurrency into small, bite-sized episodes so you can understand cryptocurrency better and start your investing journey. Srijan shares his first-hand experiences of investing in cryptocurrency, the lessons he has learned, and the wisdom he has gained on the subjects of investing, money and cryptocurrencies. Listen in to become a smart and successful crypto investor.
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Three Wall Street and Silicon Valley insiders (your friendly neighborhood Stock Jocks) provide candid, thoughtful, and most importantly, "colorful" insights on stocks, with a focus on the tech sector. Think "All-In", minus the sweater vests and tech bro culture (sorry if that hit a little close to home) -- plus a little of that locker room "spice." Laugh. Love. Trade. Win!
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Blueshift ministries this ministry is for the mature Christian for those who are ready to face there demons in their bloodline ANIMALS GO HEAVEN https://youtu.be/fP-CKPK6C70?si=2bgIVlrO-e9roiu5 WORTH OF SACRIFICE https://youtu.be/iJOeiT1IkhY?si=ixbHeC6oUaMUYPkF CAPACITY https://youtu.be/UoIl5s2c_L8?si=As5mbJEFtelzbGV6 3 DAYS OF DARKNESS https://youtu.be/fE5pIjl4pLE https://youtu.be/MdsH0qiVW80 https://youtu.be/qfQlXa0AkMY https://youtu.be/hVZQOlET7ms https://youtu.be/agbG1xexTf8 https://yout ...
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A personal finance and investing podcast on money, how it works, how to invest it and how to live without worrying about it. J. David Stein is a former Chief Investment Strategist and money manager. For close to two decades, he has been teaching individuals and institutions how to invest and handle their finances in ways that are simple to understand. More info at moneyfortherestofus.com
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Host Sweetman is shipping a lot on Base. This is one method of distribution everything from the ideas to the end product. Everything is open source & free to use: https://github.com/sweetmantech/ ⌐Ⓟ-Ⓢ practice sincerely
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Crypto assets and blockchain technology are about to transform every trust-based interaction of our lives, from financial services to identity to the Internet of Things. In this podcast, host Laura Shin, an independent journalist covering all things crypto, talks with industry pioneers about how crypto assets and blockchains will change the way we earn, spend and invest our money. Tune in to find out how Web 3.0, the decentralized web, will revolutionize our world. Disclosure: I'm a nocoiner.
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Here we share the Latest News related to Technology, Crypto, and Everything.
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Epicenter - Learn about Crypto, Blockchain, Ethereum, Bitcoin and Distributed Technologies
Epicenter Media Ltd.
Epicenter brings you in-depth conversations about the technical, economic and social implications of cryptocurrencies and blockchain technologies. Every week, we interview business leaders, engineers academics and entrepreneurs, and bring you a diverse spectrum of opinions and points of view. Epicenter is hosted by Sebastien Couture, Brian Fabian Crain, Friederike Ernst, Meher Roy and Felix Lutsch. Since 2014, our episodes have been downloaded over 8 million times.
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Ben Benson on The Performance Capability Network Thoughts on the Life of Business & the Business of Life Timely and Timeless Insights for Performance Capability, Leadership, Entrepreneurship, Sports Psychology and Organizational Effectiveness. Join Ben Benson Founder at Performance Capability a platform dedicated to exploring the dynamic interplay between the governing principles of human effectiveness and the powerful distinctions of performance development in all areas of life. This podcas ...
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Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.
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Bitcoin pioneer Charlie Shrem peels back the layers on the lives and backgrounds of the world's most impactful innovators. Centering around intimate narratives, Shrem uncovers a detailed, previously unspoken story of the genesis and evolution of bitcoin, cryptocurrency, artificial intelligence, and the web3 movements. Join Shrem as he journeys through the uncharted territories of tech revolutions, revealing the human side of the stories that shaped the digital world we live in today.
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Web3 Unraveled" is your go-to podcast for making sense of the evolving world of blockchain, cryptocurrency, and the decentralized web. We break down complex Web3 concepts like account abstraction, interoperability, and the future of digital finance in a way that's accessible to everyone. Whether you're a tech enthusiast, an investor, or simply curious about the next evolution of the internet, our episodes are designed to inform, inspire, and spark your interest in the digital revolution. Joi ...
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This podcast is a part of a series for, CBSE Class 10 Maths. We recommend that you take a look at our YouTube channel, to enter this new world of virtual learning at its best. || Youtube: Shiksha Abhiyan || t.ly/dN9j8 ||
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This podcast is a part of a series for, CBSE Class 10 Maths. We recommend that you take a look at our YouTube channel, to enter this new world of virtual learning at its best. || Youtube: Shiksha Abhiyan || t.ly/dN9j8 ||
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151: EQA of ctDNA Mutation Testing Across the COIN Consortium
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16:21️ Episode 151: EQA of ctDNA Mutation Testing Across the COIN Consortium In this episode of PaperCast Base by Base, we explore how 16 Dutch laboratories evaluated their real‑world workflows for circulating tumor DNA (ctDNA) mutation testing across BRAF, EGFR, and KRAS using a coordinated external quality assessment within the COIN consortium. Study …
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How DoubleZero Built a Faster Internet for Crypto and Helped All DePIN - Ep. 914
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36:07DoubleZero just launched its mainnet-beta, offering a new type of high-performance fiber network for blockchains, live across 5 continents and already adopted by 20%+ of Solana stake. Co-founder Austin Federa joins Unchained to walk through: How DoubleZero creates a dedicated internet for crypto Who contributes fiber and why they earn the 2Z token …
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155: EIF3A/EIF3B Loss-of-Function: A Cardiocraniofacial Neurodevelopmental Syndrome
15:53
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15:53️ Episode 155: EIF3A/EIF3B Loss-of-Function: A Cardiocraniofacial Neurodevelopmental Syndrome In this episode of PaperCast Base by Base, we explore how loss-of-function variants in EIF3A and EIF3B—core components of the eIF3 translation initiation complex—cause a multisystem disorder marked by congenital heart defects, craniofacial differences, and…
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Why Every Company Will Have a Stablecoin — and Why One L2 Isn’t Enough - Ep. 912
1:32:05
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1:32:05This week on Unchained, we’ve got a double-header. First, Zach Abrams, CEO of Bridge (acquired by Stripe), unveils Open Issuance, a platform designed to let any company launch its own stablecoin. He explains why the stablecoin duopoly is ending, why fragmentation won’t slow adoption, and how stablecoins could pair with AI to reshape global money mo…
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Bits + Bips: Where Is the Most Wealth to Be Made in Crypto: DeFi or CeFi? - Ep. 913
1:05:49
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1:05:49Crypto’s bull run may be far from over, but the battleground is shifting. On this week’s Bits + Bips, Bill Barhydt of Abra and Robert Leshner of Superstate join Ram Ahluwalia and Steven Ehrlich to debate: The current state of the markets with a looming government shutdown SWIFT’s move to build on Linea, an Ethereum layer 2 Hyperliquid vs Aster The …
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154: Multiple-testing corrections in selection scans using identity-by-descent segments
20:05
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20:05️ Episode 154: Multiple-testing corrections in selection scans using identity-by-descent segments In this episode of PaperCast Base by Base, we explore how Temple and Browning develop principled genome-wide significance thresholds for IBD-based scans of recent positive selection by explicitly modeling correlation along the genome. Study Highlights:…
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153: Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits
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15:13️ Episode 153: Skeletal muscle eQTL meta-analysis implicates genes in the genetic architecture of muscular and cardiometabolic traits In this episode of PaperCast Base by Base, we explore a large skeletal muscle eQTL meta-analysis that integrates GTEx and FUSION data to pinpoint regulatory variants and genes underlying muscular and cardiometabolic …
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From Chaos to Strength: Transforming Life’s Struggles Into Breakthroughs
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15:28Are you facing career setbacks, relationship challenges, financial stress, health struggles, or dreams that feel impossible? This episode will shift how you see your situation and help you discover the hidden strength within your chaos. Drawing on insights from interviewing 174 success stories, [Host Name] explains why your toughest challenges aren…
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152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia
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16:53️ Episode 152: One-Well Multiplex ddPCR for Hereditary Alpha Tryptasemia In this episode of PaperCast Base by Base, we explore a validated single‑well multiplex digital droplet PCR (ddPCR) assay that reconstructs the TPSAB1 locus by quantifying α‑ and β‑tryptase copy numbers to diagnose hereditary alpha tryptasemia (HαT) in symptomatic patients. St…
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#521: Red Teaming LLMs and GenAI with PyRIT
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1:02:40English is now an API. Our apps read untrusted text; they follow instructions hidden in plain sight, and sometimes they turn that text into action. If you connect a model to tools or let it read documents from the wild, you have created a brand new attack surface. In this episode, we will make that concrete. We will talk about the attacks teams are…
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150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck
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17:52️ Episode 150: Patrilineal segmentary systems and the post‑Neolithic Y‑chromosome bottleneck In this episode of PaperCast Base by Base, we explore a Nature Communications study that proposes a peaceful, socio‑cultural explanation for the sharp decline in male effective population size observed 3,000–5,000 years ago. Instead of widespread violence, …
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The Chopping Block: Perp Wars & Stablecoin Battles: Hyperliquid, Aster, Tether - Ep. 911
1:02:47
1:02:47
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1:02:47Welcome to The Chopping Block – where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. This week, we’re joined by Farooq Malik, co-founder and CEO of Rain, as two parallel wars erupt across crypto: the Perp DEX war between Hyperliquid and the CZ-backed Aster, and the deepening batt…
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Plasma's Successful Launch, Revenue Over TVL & the Future of Pump.fun - Ep. 910
1:27:54
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1:27:54How do stablecoin-first blockchains win distribution? Does TVL actually map to value? And why speculation may become the default language of online culture. In this 3-part episode, we explore three different important stories. Segment 1: CoinFund’s Seth Ginns explains how newly launched stablecoin chain Plasma aims to compete, plus why the “stablec…
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149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck
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15:04️ Episode 149: Cultural Hitchhiking and the Post‑Neolithic Y‑Chromosome Bottleneck In this episode of PaperCast Base by Base, we explore how patrilineal social structures and intergroup competition can reshape genetic diversity, offering a cultural explanation for the striking male‑specific bottleneck observed 5,000–7,000 years ago across the Old W…
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148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants
14:44
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14:44️ Episode 148: Systematic Minigene-Based Splicing Analysis and Tentative Clinical Classification of 52 CHEK2 Splice-Site Variants In this episode of PaperCast Base by Base, we explore a comprehensive functional assessment of splice-site variants in CHEK2 using reporter minigenes, revealing how disrupted pre-mRNA splicing contributes to hereditary b…
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This week there isn’t a regular Money for the Rest of Us episode, but David shares an update on what’s happening behind the scenes. He previews an exclusive Plus member livestream on the forces shaping the next decade, explains why there won’t be a new episode next week, and highlights fresh content available on YouTube, Instagram, LinkedIn, and Su…
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Why Hyperliquid Should Cut Its Total Token Supply Nearly in Half - Ep. 909
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36:32Crypto investors love to throw around “FDV” as if it’s the ultimate measure of value. But what if that number is more misleading than helpful? In this episode, DBA’s Jon Charbonneau explains his proposal to cut Hyperliquid’s supply by nearly half, why he believes FDV overstates real valuations, and how outdated tokenomics are holding projects back.…
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147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants
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15:37️ Episode 147: Comprehensive Annotation of Complete ABO Alleles and Resolution of ABO Variants In this episode of PaperCast Base by Base, we explore a groundbreaking study that introduces an improved long-read sequencing method to fully resolve ABO haplotypes, spanning from the 5′ to the 3′ untranslated regions. This work addresses a major gap in b…
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Send us a text There are many different kinds of prophets that has there training even without realizing itBy Syria
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Send us a text ARE YOU READY! Here on in we are going to go deeper into the Bible. Between the lines and divine origin. From here on in these videos will only be seen on this podcastBy Syria
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Bits + Bips: How Wall Street Could Make a Killing off the Next Crypto Winter - Ep. 908
1:01:39
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1:01:39Markets had a flood of liquidations on Monday, and traders lost over $1.5 billion in positions. So, why are liquidations spiking? Is this a warning or a blip? Also, could a flood of DAT issuance be setting the stage for not just a crypto winter, but a crypto “nuclear” winter? If so, hedge funds and market structure could accelerate the pain. This w…
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146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors
15:56
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15:56️ Episode 146: Automated and Decentralized Genomic Profiling of Plasma Cell-Free DNA in Solid Tumors In this episode of PaperCast Base by Base, we explore the clinical feasibility of an automated and decentralized cfDNA sequencing system designed to identify actionable and resistance alterations in advanced solid tumors. Study Highlights: Researche…
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#520: pyx - the other side of the uv coin (announcing pyx)
1:00:11
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1:00:11A couple years ago, Charlie Marsh lit a fire under Python tooling with Ruff and then uv. Today he’s back with something on the other side of that coin: pyx. Pyx isn’t a PyPI replacement. Think server, not just index. It mirrors PyPI, plays fine with pip or uv, and aims to make installs fast and predictable by letting a smart client talk to a smart …
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Mento: Onchain FX Markets - Decentralising World Currencies - Markus Franke
1:06:14
1:06:14
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1:06:14TradFi FX markets are slow, expensive and often lack liquidity for direct swaps between different world currencies, having to route through USD pairs. While crypto could technically solve pairing through AMM pools, those needed to be arbitraged in order to reflect TradFi rates. With 15 fully-backed stablecoins, Mento is building the largest FX infr…
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145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD
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16:59️ Episode 145: A Validated Highly Sensitive Microsatellite Instability Assay Identifies PMS2 Variants in CMMRD In this episode of PaperCast Base by Base, we explore a study that validates a next-generation sequencing-based highly sensitive microsatellite instability (hs-MSI) assay for the diagnosis of constitutional mismatch repair deficiency (CMMR…
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144: Revised time estimation of the ancestral human chromosome 2 fusion
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17:10️ Episode 144: Revised time estimation of the ancestral human chromosome 2 fusion In this episode of PaperCast Base by Base, we explore a study that revisits one of the most defining events in human evolution: the fusion that gave rise to chromosome 2. This work refines previous estimates and provides a clearer timeline for when this pivotal genomi…
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143: The genetic history of the Southern Caucasus: 5,000 years of continuity despite high mobility
18:56
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18:56️ Episode 143: The genetic history of the Southern Caucasus: 5,000 years of continuity despite high mobility In this episode of PaperCast Base by Base, we explore a comprehensive archaeogenomic study tracing 230 ancient individuals from Georgia and Armenia over 5,000 years, from the Bronze Age to the Early Middle Ages. The research investigates how…
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Debate: Should Stablecoin Chains Have an Ethereum L2 or Their Own L1? - Ep. 907
1:25:35
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1:25:35In this episode, Cyber Capital’s Justin Bons and Codex’s Haonan Li challenge the new orthodoxy: whether payments chains should be alt L1s or Ethereum L2s, how “neutrality” and finality matter for real-world transactions, and why fragmentation could make or break onchain dollars. We dig into Stripe’s Tempo (and its permissioned start), what it would…
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142: Specifications of the ACMG/AMP Guidelines for PALB2 Variant Interpretation
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16:35️ Episode 142: Specifications of the ACMG/AMP Guidelines for PALB2 Variant Interpretation In this episode of PaperCast Base by Base, we explore how the Hereditary Breast, Ovarian, and Pancreatic Cancer Variant Curation Expert Panel (HBOP VCEP) developed gene-specific ACMG/AMP guidelines for the interpretation of PALB2 germline sequence variants, a …
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The Chopping Block: Stablecoin-as-a-Service: The Next Big Crypto Gold Rush? - Ep. 906
1:00:44
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1:00:44Welcome to The Chopping Block – where crypto insiders Haseeb Qureshi, Tom Schmidt, Tarun Chitra, and Robert Leshner chop it up about the latest in crypto. This week, we’re joined by Gordon Liao, Chief Economist at Circle, to dissect the Stablecoin Wars. From Circle’s Arc and Stripe + Paradigm’s Tempo, to Solana’s native stablecoin push and Hyperliq…
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141: RetiGene, a comprehensive gene atlas for inherited retinal diseases
26:12
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26:12️ Episode 141: RetiGene, a comprehensive gene atlas for inherited retinal diseases In this episode of PaperCast Base by Base, we explore RetiGene, an expert-curated resource that consolidates genetic, transcriptomic, and functional information on inherited retinal diseases (IRDs). The study highlights the urgent need for a unified gene catalog to g…
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#519: Data Science Cloud Lessons at Scale
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1:02:56Today on Talk Python: What really happens when your data work outgrows your laptop. Matthew Rocklin, creator of Dask and cofounder of Coiled, and Nat Tabris a staff software engineer at Coiled join me to unpack the messy truth of cloud-scale Python. During the episode we actually spin up a 1,000 core cluster from a notebook, twice! We also discuss …
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Resilient Wealth in an Era of Infinite Money
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25:53What happens when the money supply grows too slowly or too quickly? From gold-standard deflation to QE-driven inflation and inequality, we trace the lessons of monetary history, and what we can do today to protect ourselves in an age of infinite money. Topics covered include: How is the money supply measured, and why is it a subjective exercise Wha…
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Bits + Bips: Could a Base Token Be Coinbase's Key to a Super App? - Ep. 905
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1:04:31This week on Bits + Bips, hosts Steve Ehrlich and Ram Ahluwalia speak with Blockchain.com’s Nic Cary and Franklin Templeton’s Max Gokhman. We talk about how the potential Base token would alter the L2 landscape, and who should capture the value if Coinbase becomes the backbone for DeFi. Also, whether Web2 and TradFi giants will buy their way onchai…
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140: Landscapes of missense variant impact for human superoxide dismutase 1
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20:18️ Episode 140: Landscapes of missense variant impact for human superoxide dismutase 1 In this episode of PaperCast Base by Base, we explore a large-scale functional analysis of missense variants in SOD1, a key gene implicated in amyotrophic lateral sclerosis (ALS). The study addresses the challenge of classifying variants of uncertain significance …
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Base Will Likely Have a Token: Why Now, Who Wins, and How Big It Gets - Ep. 904
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49:48Base just crossed its own Rubicon. After months of saying “no token,” Jesse Pollak now says Base must decentralize and is “exploring” a token. What changed? On this episode, Proof of Play’s ICO Beast and former Coinbase Ventures investor Ryan Yi unpack why “exploring” is the operative word, how policy (the Clarity Act) could shape the rollout, and …
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139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data
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14:03️ Episode 139: MosCoverY: A new method to estimate mosaic loss of Y chromosome from sequencing coverage data In this episode of PaperCast Base by Base, we explore the development of MosCoverY, a computational method designed to detect and quantify mosaic loss of the Y chromosome (mLOY) from exome and whole-genome sequencing data. This condition, th…
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138: Social exposome and brain health outcomes of dementia across Latin America
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19:43️ Episode 138: Social exposome and brain health outcomes of dementia across Latin America In this episode of PaperCast Base by Base, we explore how a multidimensional social exposome across the lifespan—covering education, food insecurity, financial status, assets, access to healthcare, childhood labor, subjective socioeconomic status, childhood ex…
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137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views
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25:11️ Episode 137: Rethinking RNA-binding proteins: Riboregulation challenges prevailing views In this episode of PaperCast Base by Base, we explore how a sweeping expansion of the RNA-binding proteome has reframed long‑held assumptions about RNA–protein interactions, spotlighting ‘non‑canonical’ RBPs and the emerging concept of riboregulation—RNA dire…
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f(x) Protocol: Decentralized Yield-Bearing Stablecoin & 0-Liquidation Perp - Cyrille Brière
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1:00:22Without a doubt, the introduction of stablecoins has vastly increased overall crypto liquidity, adoption and real-world use cases as they offered a safe haven against the industry’s volatility, especially during bearmarkets. However, despite being extremely efficient, the main stablecoin actors (i.e. Circle & Tether) are centralised entities. Many …
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Euler: The DeFi Super App - Michael Bentley
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1:00:01Euler is a DeFi lending protocol built around the idea of permissionless modularity, enabling users to lend and borrow almost any crypto asset with flexible, permissionless pools, tailored to individual risk profiles. Moreover, Euler Vault Kit (EVK) and Ethereum Vault Connector (EVC) enable the creation of custom lending vaults which, in turn, can …
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136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance
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14:48️ Episode 136: Gene Context Drift Identifies Drug Targets to Mitigate Cancer Treatment Resistance In this episode of PaperCast Base by Base, we explore RECODR, a graph‑embedding pipeline that reads single‑cell and single‑nucleus transcriptomes as co‑expression networks to quantify “gene context drift” during therapy and expose druggable vulnerabili…
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Send us a text ONLY! Love by the expectations that Father in Heaven Elohim Yawah has for you and NO! one else’sBy Syria
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The Chopping Block: USDH Bake-off—Native Markets, Validators & the “Beauty Contest” Debate - Ep. 903
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56:55Hyperliquid’s USDH ticker set off the most dramatic “RFP” in recent memory. The crew breaks down why Native Markets ran away with validator support, whether the process was theater or strategy, and how the Bake-off became a marketing masterstroke—and potential leverage on Circle. We dig into Polymarket odds, the last‑minute Paxos bribery allegation…
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