Best Clinical Guidelines Program Podcasts (2026)

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222 - How ICH Guidelines Are Organized: Understanding the Q, S, E, and M Series 12:13

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2h ago12:13

12:13

In this episode of Let’s Combinate: Drugs + Devices, host Subhi Saadeh continues the Combinating with ICH series by breaking down how the International Council for Harmonisation (ICH) guidelines are organized and why that structure matters for drug and drug-device combination products. Subhi walks through the four main ICH guideline families, Quali…

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Antibiotic Prescribing in Dentistry + Gut Microbiome – PDP254 45:36

12h ago45:36

45:36

When are antibiotics truly indicated in dentistry? How do you manage the patient who’s begging for a prescription? And what impact are we having on the gut every time we prescribe unnecessarily? In this episode, Dr. Jeremy Lenaerts joins Jaz to explore the world of antibiotics in dentistry. Together, they cover when to prescribe, when not to, and w…

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Exploring the Complexity of Cancer: How mRNA Vaccines Could Change Everything

13h ago

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Discussion of challenges and opportunities for therapeutic mRNA cancer vaccines. Learn more about Elias Sayour, MD, PhDBy UF Health Shands Hospital

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Two New Treatments for Gonorrhea; one is available now! 15:20

1d ago15:20

15:20

In this episode of the Conversations with CEI, infectious disease specialist Dr. Steven Fine delves into groundbreaking advancements in the treatment of urogenital gonorrhea. The episode highlights the FDA's December 2025 approval of two innovative oral therapies that mark a significant step forward in combating this prevalent sexually transmitted …

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Artificial Intelligence and the Future of Psychiatry with Dr. Allen Frances 45:50

42m ago45:50

45:50

Psychiatry stands at the threshold of one of its greatest disruptions, the rise of artificial intelligence. In this episode, Dr. Mark Mullen speaks with Dr. Allen Frances, Professor Emeritus and former Chair of Psychiatry at Duke University and Chair of the DSM-IV Task Force, about the clinical, ethical, and societal implications of AI’s rapid entr…

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Disaster Podcast 2025 Year In Review 39:23

2h ago39:23

39:23

We gather our podcast regulars for a look at the past year on the show with our 2025 Disaster Podcast year in review. Dr. Joe Holley joined co-hosts Sam Bradley and Jamie Davis for this episode. Kyle Nelson, Becky DePodwin, and Dan DePodwin sent in their top episode picks by email. Joe Holley kicks off the look back at last year with a vote for the…

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221 - What Is ICH and Why It Matters 14:30

8d ago14:30

14:30

In this episode of Let’s Combinate: Drugs + Devices, Subhi Saadeh kicks off a new series focused on the International Council for Harmonisation (ICH) and its impact on drug and drug–device combination products.Subhi introduces what ICH is, why it was created, and how its guidelines shape global expectations for pharmaceutical quality, safety, effic…

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Your Patient’s Face Might Be Causing Their Sleep Problem with Dr Dave Singh – PDP253 1:10:40

7d ago1:10:40

1:10:40

Can adults really expand their maxilla? Is treating sleep apnea with a CPAP or mandibular advancement device only MASKING the problem? How does craniofacial anatomy influence airway health, and what should dentists look for? Dr. Dave Singh joins us to dive into CranioFacial Sleep Medicine. He breaks down how structural issues—like a narrow maxilla,…

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Case 13. Got PrEP? HIV Adjacent Care 31:41

9d ago31:41

31:41

Like many in HIV, Chris is also a PrEP provider. In this episode, he presents a case to Dr. Rona Vail to work through the best approach to PrEP for a young, gay Black man. They work through the issues of oral vs injectable PrEP, dosing schedules for oral PrEP, the studies that support each approach, and this patient’s eligibility for each to determ…

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220 - Managing Oneself, Reflections and a New Series on ICH 8:29

6d ago8:29

8:29

🚀 Stay ahead in combination products, pharma, and medical devices 👉 https://www.letscombinate.com 🎙️ Listen to more expert discussions on regulations, drug delivery, and quality 👉 https://www.letscombinate.com/ Get expert insights on FDA regulations, risk management, quality systems, and the latest trends in drug-device combination products. In thi…

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Best of 2025: A Year of Shared Learning 50:40

15d ago50:40

50:40

Happy New Year, Protruserati ✨ As 2025 comes to a close, we wanted to pause and reflect by revisiting the moments that genuinely shaped how we practise, think, and show up in the clinic. This Best of 2025 episode starts with restorative and aesthetics, moves through digital workflows, endo, paediatrics, surgery, communication, and finishes with wha…

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The Role Testosterone Plays in Male Fertility?

8d ago

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In this episode, Dr. Kevin Campbell, assistant professor of medicine in the Department of Urology at the University of Florida College of Medicine, discusses the relationship between testosterone levels and male fertility. We dive into symptoms, diagnosis, and how testosterone therapy can impact fertility. Learn how understanding these connections …

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Beyond Boot Camp: Conversations on Psychiatry's Future (Season 4 Trailer) 1:33

16d ago1:33

1:33

Welcome to Season 4! Join Dr. Mark Mullen and expert guests as we explore AI in psychotherapy, emerging treatments, and the ethical, clinical questions reshaping psychiatric care, and MUCH more. To share topic ideas, ask questions, and get more of the pod, visit psychiatrybootcamp.com Learn more about your ad choices. Visit megaphone.fm/adchoices…

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219 - FDA PreCheck and the Future of Inspections: PAI to Pre-Readiness 25:30

22d ago25:30

25:30

In this episode of Let’s Combinate: Drugs + Devices, host Subhi Saadeh is joined by Ben Locwin to break down what’s changing in FDA pre-approval and pre-license inspections—and why the “inspection side” of approval is becoming a bigger conversation. They cover how PAIs and PLIs fit into the approval pathway, why Complete Response Letters (CRLs) can…

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We All Have TWO Bites with Bobby Supple – PDP252 1:09:18

23d ago1:09:18

1:09:18

Do your patients really have two bites? Does their bite change when they lie down? When they sleep? And how can you explain centric relation, posture, and deprogramming in a way that patients actually understand? Dr. Bobby Supple joins Jaz for a powerful episode unpacking one of the most misunderstood topics in occlusion: the daytime chewing bite v…

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Holiday Greetings 0:41

22d ago0:41

0:41

Hello Viremic listeners. We are taking a break this week and encourage you to take a look back at our past episodes and catch up on any cases you may have missed. We'll be back on January 6, 2026 with a new case to discuss! From all of us at Viremic we hope you have a peaceful, healthy and joyous holiday season!…

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218 - ICH Q13: Continuous Manufacturing EXPLAINED (Batch vs. Continuous) 9:10

20d ago9:10

9:10

In this short episode of Let’s Combinate: Drugs + Devices, Subhi Saadeh breaks down ICH Q13 and what “continuous manufacturing” actually means. He compares batch vs. continuous, explains how a batch still exists in continuous manufacturing, and covers the essentials quality teams care about: RTD/traceability, control strategy, and disturbances/dive…

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Avoiding Surgery with Micrognathia: Novel Oral Airway Appliance

21d ago

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The oral airway appliance (OAP) is an innovative alternative to surgery in patients with Pierre Robin Sequence and airway concerns. It allows the child to avoid the risks of surgery, feed orally, and be discharged safely. Additional benefits include the narrowing of cleft palate width if a cleft is present and induction of mandibular catch-up growt…

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Parenthood and Dentistry – Life Leverage for Unique Challenges – IC065 58:08

29d ago58:08

58:08

How do you balance a high-performance dental career with being an effective parent? What strategies help you stay sane amidst the organized chaos of family life? How can showing up as your best self benefit both your patients and your children? Dr. Shandy Vijayan and Dr. Raabiha Maan join Jaz in this nonclinical episode to share their experiences o…

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Most Recent Clinical Research — Elevated CPR Discussion Part 5 1:02:01

1M ago1:02:01

1:02:01

Kurt Bramer from Advanced CPR Solutions comes back for a final look at Head-Up CPR as we pull all the pieces from the earlier four episodes together. Dr. Joe Holley is back to bring in the latest research into the process as well. We will tie all this back to the global health disaster that is sudden cardiac arrest. Recent research from across the …

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217 - 5 Fixable Problems Holding Back Drug–Device Programs 17:30

27d ago17:30

17:30

In this episode of Let's Combinate: Drugs + Devices, host Subhi Saadeh addresses five significant quality issues in the combination product space. This episode provides practical insights and strategies for overcoming these common hurdles to enhance quality and efficiency in developing combination products. 00:00 Introduction and Host Background 00…

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Case 12. Injectable ART Failure: Minor Risk of a Major Event 29:13

1M ago29:13

29:13

After 3 years on injectable CAB/RPV, a patient develops viremia, with a viral load of ~1,300 copies/mL. Failure of injectable CAB/RPV occurs in 1% to 2%, despite adherence. What factors have been associated with CAB/RPV failure? Can regimen failure be predicted or prevented? Listen as Chris and Eileen discuss the data, their advice to patients cons…

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Moving to USA for Dentistry (Advanced Standing Programs and Specialist Pathways for International Dentists) – IC064 1:11:20

1M ago1:11:20

1:11:20

Thinking of moving to the USA as a dentist? Wondering what exams, applications, and documents you’ll need to practice or specialize there? Curious about how much it costs — and what life as a dentist in the States is really like? Dr. Hazel Kerr and Dr. Dorrin Reyhani join Jaz for a deep dive into everything you need to know about moving to America …

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The Science and Physiology of Head-up CPR – Elevated CPR Discussion Part 4 54:51

1M ago54:51

54:51

Kurt Bramer from Advanced CPR Solutions returns again this week to continue the series on Head-Up CPR and other promising sudden cardiac arrest treatments. There are three previous episodes in this series. Elevated CPR Series Episode One Elevated CPR Series Episode Two Elevated CPR Series Episode Three Elevated CPR Series Episode Five After the sev…

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Advances in “Liquid Biopsy” and Circulating Tumor DNA

1M ago

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In this episode, Dr. Peter Dziegielewski explores the concept of liquid biopsy—an innovative approach to cancer diagnosis. Learn about its applications in tracking treatment efficacy, monitoring minimal residual disease, and the evolving role of circulating tumor DNA. This episode is essential for anyone interested in the future of oncology. Don’t …

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216 - How UAE and Singapore Are Redefining Regulatory Innovation with Stephen O'Rourke 21:51

1M ago21:51

21:51

In this episode of Let’s Combinate: Drugs + Devices, host Subhi Saadeh speaks with Steven O'Rourke, regulatory strategist and founder of Clarifi, a consultancy helping MedTech, biotech, and novel food startups navigate EU and US regulatory pathways. They discuss: - The hidden costs of regulatory failure and how to avoid them - Why early engagement …

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Understanding Cracked Tooth Syndrome and the Dental Occlusion Triad – PS019 52:45

1M ago52:45

52:45

You’re doing a routine exam when you spot it – a stained hairline crack snaking across the marginal ridge of a molar. Your patient hasn’t mentioned any symptoms… Yet. Should you sound the alarm? Monitor and wait? Jump straight to treatment? Cracked teeth are one of dentistry’s most misunderstood diagnoses. Colleagues debate whether to crown or moni…

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Changes in AHA CPR and Cardiac Arrest Guidelines Over the Years – Elevated CPR Discussion Part 3 1:00:48

2M ago1:00:48

1:00:48

We are joined by Kurt Bramer from Advanced CPR Solutions again this week to continue the series on Head-Up CPR and other promising sudden cardiac arrest treatments. He and Dr. Joe Holley kicked off the discussion in two previous episodes. Elevated CPR Series Episode One Elevated CPR Series Episode Two Elevated CPR Series Episode Four Elevated CPR S…

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Safeguarding Children – Actions, Scripts and Guidance – PDP251 45:23

2M ago45:23

45:23

Are you confident in spotting a child at risk of neglect? Do you know what to do if you witness abuse in your practice? How can you raise concerns safely while protecting both the child and your team? This episode with Dr. Christine Park provides tangible actions, practical scripts, and clear guidance for managing challenging scenarios—like seeing …

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215 - Why Aren’t Technical People Leading Drug-Device Audits? 13:59

1M ago13:59

13:59

In this episode of Let’s Combinate, Subhi Saadeh breaks down why more engineers in pharma, medical devices, and combination products should seriously consider becoming auditors. Sparked by a question at a PDA conference: “Why don’t more technical people lead audits?” This episode explores the gap between technical expertise and true audit competenc…

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Case 11. Unfolding Stories to Untangle Syphilis Testing 37:13

2M ago37:13

37:13

A 32-year-old man with well-controlled HIV, seen after a recent relationship split and sexual activity with new partners, is screened and diagnosed with syphilis. Eileen discusses this case with guest Dr. Matthew Hamill, who reviews his approach to STI screening and risk reduction, emphasizing an approach that normalizes screening. Matthew then rev…

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Occlusion for Aligners – Clinical Guidelines for GDPs – PDP250 1:04:18

2M ago1:04:18

1:04:18

Let’s be honest – the occlusion after Aligner cases can be a little ‘off’ (even after fixed appliances!) How do you know if your patient’s occlusion after aligner treatment is acceptable or risky? What practical guidelines can general dentists follow to manage occlusion when orthodontic results aren’t textbook-perfect? Jaz and Dr. Jesper Hatt explo…

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Flawed Approaches to Sudden Cardiac Arrest Research – Elevated CPR Discussion Part 2 28:03

2M ago28:03

28:03

Kurt Bramer from Advanced CPR Solutions comes back on the show this week to continue the series on Head-Up CPR and other promising sudden cardiac arrest treatments. He and Dr. Joe Holley kicked off the discussion in a previous episode. Elevated CPR Series Episode One Elevated CPR Series Episode Three Elevated CPR Series Episode Four Elevated CPR Se…

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PrEParing for Lenacapavir Implementation in Your Clinic: Early Lessons Learned 28:23

2M ago28:23

28:23

On June 18, 2025, the FDA approved Yeztugo, the brand name for subcutaneous lenacapavir, a prescription medication used for the pre-exposure prophylaxis of HIV. Subcutaneous lenacapavir is administered twice a year (every six months) to reduce the risk of sexually acquired HIV-1 infection in adults and adolescents at risk. With patients only needin…

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Surgical Extrusion Technique Update – Alternative to Ortho Extrusion or CLS – PDP249 1:07:28

2M ago1:07:28

1:07:28

Do you have a “hopeless” retained root you’re ready to extract? Think implants, dentures, or bridges are the only way forward? What if there’s a way to save that tooth — predictably and biologically? In this episode, Dr. Vala Seif shares his experience with the Surgical Extrusion Technique — a game-changing approach that lets you reposition the roo…

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214 - The Best 5 Certifications for ANY Quality Career Path (CQE, Green Belt, CQA & More) 19:15

2M ago19:15

19:15

In this episode of Let's Combinate: Drugs + Devices host Subhi Saadeh welcomes back Andy Robertson, founder of CQE Academy. Andy shares his transformative journey involving CQE certification and how it boosted his confidence and expertise in quality engineering. They explore the practical applications of Design of Experiments (DOE), including a rea…

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Chronic Lung Allograft Dysfunction: Where Are We in 2025?

2M ago

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Dr Valverde will Explore the frontiers of transplant immunology, challenges and, hope in long-term graft survival. Learn more about Adriana Valverde Zuniga, MDBy UF Health Shands Hospital

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Replacement Options for Incisors – Denture? Bridge? Implant? – PS018 52:11

2M ago52:11

52:11

Are you confident in replacing a single missing central incisor? When is a denture the right option — and when should you consider a bridge or implant instead? Why is the single central incisor one of the hardest teeth to replace to a patient’s satisfaction? In this Back to Basics episode, Jaz and Protrusive Student Emma Hutchison explore the uniqu…

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The Global Disaster of Sudden Cardiac Arrest — Elevated CPR Discussion Part 1 35:05

2M ago35:05

35:05

Kurt Bramer from Advanced CPR Solutions comes on the show this week with Dr. Joe Holley. Kurt has a background in EMS since 1979 and worked as an emergency manager in Minneapolis. He currently works for Advanced CPR Solutions as a clinical educator. Sudden cardiac arrest is a global disaster that rivals the recent viral pandemic in scope. Cardiac a…

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Keeping an Eye on STIs – Have You Heard of TMVII? 18:04

2M ago18:04

18:04

This month, host Dr. Marguerite Urban chats with Dr. Jason Zucker, an adult and pediatric infectious diseases physician at Columbia University and the assistant medical director of the New York City HIV/STI Prevention Training Center, about an emerging fungal infection, Trichophyton mentagrophytes Genotype VII, also known as TMVII. Curious about wh…

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“I Committed Fraud – Learn from My Mistakes” – PDP248 6:40

2M ago6:40

6:40

What if one bad decision completely changed the course of your career? In this exclusive, members-only episode, Jaz sits down with a fellow dentist from our community who shares his raw, honest story about a moment of misjudgment — committing fraud — and the painful lessons that followed. This isn’t about blame. It’s about insight, accountability, …

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213 - From Generic Underdog to Billion‑Dollar Exit: How Usman Ahmed Built & Sold a Sterile Injectable Site 43:30

2M ago43:30

43:30

What happens when you go all in on a generic injectable that no one else wants, and it turns into a one hundred million dollar product in the first year? In this episode of Let’s Combinate: Drugs + Devices, host Subhi Saadeh speaks with Usman Ahmad, former CEO of Nexus Pharmaceuticals and now CEO of Quetzal Therapeutics. Together they trace his jou…

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Case 10. A Growing Problem: ART-Associated Weight Gain 30:11

2M ago30:11

30:11

A 54-year-old woman with longstanding HIV and obesity is stable on ART, but concerned that it is causing weight gain. How best to address this growing concern? Listen as Chris and Eileen decipher the evidence related to weight gain and ART and weigh the best strategies for addressing this increasingly common and social media inflected concern for p…

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Occlusograms are Lying To Us! Don’t Trust the ‘Heat Map’ – PDP247 43:09

2M ago43:09

43:09

Ever had a patient swear their bite feels “off” – even though the articulating paper marks look perfect and you’ve adjusted everything twice over? Or maybe you’ve placed a beautiful quadrant of onlays, only to have them return saying, “these three teeth still feel proud.” If that sounds familiar, you’re not alone. In this episode, I’m joined (in my…