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Stroke Alert

Negar Asdaghi, MD, MSc, FRCPC, FAHA

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Stroke has launched a monthly podcast, Stroke Alert. Hosted by Dr. Negar Asdaghi, each episode begins by posing key takeaway questions from featured articles in the current issue of Stroke. This is followed by a brief summary and analysis of these articles, as well as an interview with the author of one of these featured articles or with one of the Stroke editors.
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On Episode 59 of the Stroke Alert Podcast, host Dr. Negar Asdaghi is joined by Dr. Eva Mistry, Stroke Associate Editor and Vice Chair of Research and Divisional Director of Vascular Neurology at the Department of Neurology and Rehabilitation Medicine at the University of Cincinnati, for the 2025 Ralph Sacco Review of Top Cerebrovascular Research. I…
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On Episode 58 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2025 issue of Stroke: "Fingolimod as a Potential Cerebroprotectant Results From the Stroke Preclinical Assessment Network" and "Apixaban and Recurrent Stroke Risk With Left Ventricular Dysfunction: A Secondary Analysis of the ARCADIA Trial." …
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On Episode 57 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2025 issue of Stroke: "Oxygen Extraction Fraction on Baseline MRI Predicts Infarction Growth in Successfully Reperfused Patients" and "Tadalafil Treatment in Patients With Cerebral Small Vessel Disease: The ETLAS-2 Randomized Clinical Trial." …
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On Episode 56 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2025 issue of Stroke: "Glucagon-Like Peptide-1 Receptor Agonists and Risk of Nontraumatic Intracerebral Hemorrhage in Patients With Type 2 Diabetes" and "White Matter Hyperintensity Multispot Pattern Lesions and Cerebrovascular Amyloid Burde…
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On Episode 55 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2025 issue of Stroke: "Anticoagulation Timing in Acute Stroke With Atrial Fibrillation According to Chronic Kidney Disease: The OPTIMAS Trial" and "Risk of Intracranial Hemorrhage With Apixaban Versus Aspirin Therapy: A Meta-Analysis of Randomi…
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On Episode 54 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2025 issue of Stroke: "Association of the Timing and Type of Acute Symptomatic Seizures With Poststroke Epilepsy and Mortality" and "Effect of Argatroban Plus Dual Antiplatelet in Branch Atherosclerosis Disease: A Randomized Clinical Trial." She …
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On Episode 53 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2025 issue of Stroke: "Effects of Intensive Blood Pressure Lowering on Brain Swelling in Thrombolyzed Acute Ischemic Stroke: The ENCHANTED Results" and "Association of Ischemic Core Hypodensity With Thrombectomy Treatment Effect in Large Core Str…
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On Episode 52 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the May 2025 issue of Stroke: "Assessing the Impact of the COVID-19 Pandemic on Childhood Arterial Ischemic Stroke: An Unanticipated Natural Experiment" and "Low Hemoglobin Causes Hematoma Expansion and Poor Intracerebral Hemorrhage Outcomes." She also in…
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On Episode 51 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2025 issue of Stroke: "Clinical Severity and Outcomes in Large Infarcts With Endovascular Therapy: A Post Hoc Analysis of the ANGEL-ASPECT Trial" and "Association Between Thrombus Composition and Etiology in Patients With Acute Ischemic Stroke T…
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On Episode 50 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2025 issue of Stroke: "Impact of Subarachnoid Hemorrhage on Human Glymphatic Function: A Time-Evolution Magnetic Resonance Imaging Study" and "Thrombolysis for Ischemic Stroke Beyond the 4.5-Hour Window: A Meta-Analysis of Randomized Clinical Tr…
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On Episode 49 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the February 2025 issue of Stroke: "Safety of Adjunctive Intraarterial Tenecteplase Following Mechanical Thrombectomy: The ALLY Pilot Trial" and "Large-Scale Plasma Proteomics Profiles for Predicting Ischemic Stroke Risk in the General Population." She al…
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On Episode 48 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2025 issue of Stroke: "Hypoglycemic Events May Trigger Acute Ischemic Stroke Within 30 Days in Those With Diabetes: A Case-Crossover Study" and "Efficacy and Safety of a Dedicated Device for Cerebral Venous Thrombectomy: A Pilot Randomized Cli…
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On Episode 47 of the Stroke Alert Podcast, host Dr. Negar Asdaghi is joined by Dr. Ashutosh Jadhav, Professor of Neurology and Neurosurgery at the Barrow Neurological Institute, for the 2024 Ralph Sacco Review of Top Cerebrovascular Research. In honor of the late Dr. Ralph L. Sacco, former Editor-in-Chief of Stroke, who died in January 2023, Drs. A…
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On Episode 46 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2024 issue of Stroke: "Cerebrovascular Events in Patients Undergoing Transcatheter Aortic Valve Replacement: A Review" and "Oxygen Extraction Fraction Mapping on Admission Magnetic Resonance Imaging May Predict Recovery of Hyperacute Ischemic…
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On Episode 45 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2024 issue of Stroke: "Cigarette Smoking and Observed Growth of Unruptured Intracranial Aneurysms: A Systematic Literature Review and Meta-Analysis" and "Clinical and Prognostic Characteristics of Acute BAD–Related Stroke: A Multicenter MRI–Ba…
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On Episode 44 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2024 issue of Stroke: "Stroke Risk After Emergency Department Treat-and-Release Visit for a Fall" and "Higher Risk of Mental Illness in Patients with Diagnosed and Untreated, Unruptured Intracranial Aneurysm: Findings from a Nationwide Cohor…
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On Episode 43 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2024 issue of Stroke: "Diagnostic Accuracy of Posterior/Anterior Periventricular WMH Ratio to Differentiate CAA From Hypertensive Arteriopathy" and "Statin Overuse in Cerebral Ischemia Without Indications: Systematic Review and Annual US Burden…
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On Episode 42 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2024 issue of Stroke: "Dual Antiplatelet Therapy After Embolic Stroke of Undetermined Source: A Subgroup Analysis of the CHANCE-2 Trial" and "Risk of Stroke in Women Using Levonorgestrel-Releasing Intrauterine Device for Contraception." She also …
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On Episode 41 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2024 issue of Stroke: "Global, Regional, and National Burdens of Stroke in Children and Adolescents From 1990 to 2019: A Population-Based Study" and "Head Injury and Risk of Incident Ischemic Stroke in Community-Dwelling Adults." She also intervi…
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On Episode 40 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the May 2024 issue of Stroke: "Incidence and Outcomes of Posterior Circulation Involvement in Moyamoya Disease" and "Glymphatic System Impairment Contributes to the Formation of Brain Edema After Ischemic Stroke." She also interviews Dr. Susanne van Veluw…
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On Episode 39 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2024 issue of Stroke: "Intravenous Tirofiban Versus Alteplase Before Endovascular Treatment in Acute Ischemic Stroke: A Pooled Analysis of the DEVT and RESCUE BT Trials" and "Radial Versus Femoral Access for Mechanical Thrombectomy in Stroke Pat…
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On Episode 38 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2024 issue of Stroke: "High-Serum Brain-Derived Neurotrophic Factor Levels Are Associated With Decreased Risk of Poststroke Cognitive Impairment" and "Long-Term Risk of Arterial Thrombosis After Intracerebral Hemorrhage: MUCH-Italy." She also in…
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On Episode 37 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the February 2024 issue of Stroke: "Intravenous Thrombolysis Before Endovascular Treatment in Posterior Circulation Occlusions: A MR CLEAN Registry Study" and "Effect of the Factor XIa Inhibitor Asundexian According to Baseline Infarct Pattern and on MRI …
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On Episode 36 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2024 issue of Stroke: "Time Window for Induced Hypertension in Acute Small Vessel Occlusive Stroke With Early Neurological Deterioration" and "Patent Foramen Ovale Management for Secondary Stroke Prevention: State-of-the-Art Appraisal of Curre…
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On Episode 35 of the Stroke Alert Podcast, host Dr. Negar Asdaghi is joined by Dr. Ashkan Shoamanesh, Associate Professor of Neurology at McMaster University, for the inaugural 2023 Ralph L. Sacco Review of Top Cerebrovascular Research of the Year. In honor of the late Dr. Ralph L. Sacco, former Editor-in-Chief of Stroke, who died in January 2023, …
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On Episode 34 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2023 issue of Stroke: "Identification of Clinically Relevant Brain Endothelial Cell Biomarkers in Plasma" and "Robot-Assisted Transcranial Doppler Versus Transthoracic Echocardiography for Right to Left Shunt Detection." She also interviews D…
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On Episode 33 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2023 issue of Stroke: "Spreading Depolarizations Suppress Hematoma Growth in Hyperacute Intracerebral Hemorrhage in Mice" and "Comment on the 2023 Guidelines for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage." She also int…
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On Episode 32 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2023 issue of Stroke: "Prestroke and Poststroke Sulfonylurea Exposure and Functional Outcomes: A Post Hoc Analysis of the SHINE Trial" and "Sleep Duration Is Associated With Subclinical Carotid Plaque Burden." She also interviews Dr. Alexand…
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On Episode 31 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2023 issue of Stroke: "Cancer Prediction With Machine Learning of Thrombi From Thrombectomy in Stroke: Multicenter Development and Validation" and "Differences in Stroke Recurrence Risk Between Atrial Fibrillation Detected on ECG and 14-Day Car…
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On Episode 30 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2023 issue of Stroke: "Temporal Trends and Determinants of Stroke Risk in Patients With Medically Treated Asymptomatic Carotid Stenosis" and "Diffusion-Weighted Imaging Lesion Reversal in Older Patients With Stroke Treated With Mechanical Thrombe…
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On Episode 29 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2023 issue of Stroke: "Prevalence and Procedural Risk of Intracranial Atherosclerotic Stenosis Coexisting With Unruptured Intracranial Aneurysm" and "Adolescent Hypertension Is Associated With Stroke in Young Adulthood: A Nationwide Cohort of 1.9…
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On Episode 28 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the May 2023 issue of Stroke: "Decreased Estimated Glomerular Filtration Rate and Proteinuria and Long-Term Outcomes After Ischemic Stroke: A Longitudinal Observational Cohort Study" and "Stroke Prevention and Treatment in People With Type 2 Diabetes: Is …
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On Episode 27 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2023 issue of Stroke: "Association Between Hospital-Documented Atrial Fibrillation and Central Retinal Artery Occlusion" and "Early Stroke and Mortality After Percutaneous Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation." Sh…
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On Episode 26 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2023 issue of Stroke: "Tenecteplase Treatment and Thrombus Characteristics Associated With Early Reperfusion" and "Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke." She also interviews Dr. Mitchell Elkind abo…
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On Episode 25 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the February 2023 issue of Stroke: "Early Antiplatelet Resumption and the Risks of Major Bleeding After Intracerebral Hemorrhage" and "Using Noncontrast Computed Tomography to Improve Prediction of Intracerebral Hemorrhage Expansion." She also interviews …
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On Episode 24 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the January 2023 issue of Stroke: "Covert Brain Infarction as a Risk Factor for Stroke Recurrence in Patients With Atrial Fibrillation" and "Subarachnoid Hemorrhage During Pregnancy and Puerperium." She also interviews Dr. Georgios Tsivgoulis about his ar…
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On Episode 23 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the December 2022 issue of Stroke: "Direct, Indirect, and Combined Extracranial-to-Intracranial Bypass for Adult Moyamoya Disease" and "Contemporary Incidence and Burden of Cerebral Venous Sinus Thrombosis in Children of the United States." She also inter…
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On Episode 22 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the November 2022 issue of Stroke: "Estimating Perfusion Deficits in Acute Stroke Patients Without Perfusion Imaging" and "Five-Year Results of Coronary Artery Bypass Grafting With or Without Carotid Endarterectomy in Patients With Asymptomatic Carotid Ar…
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On Episode 21 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the October 2022 issue of Stroke: "Oral Contraceptives, Hormone Replacement Therapy, and Stroke Risk" and "Effectiveness and Safety of Antithrombotic Medication in Patients With Atrial Fibrillation and Intracranial Hemorrhage." She also interviews Dr. Sha…
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On Episode 20 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the September 2022 issue of Stroke: "Transdural Revascularization by Multiple Burrhole After Erythropoietin in Stroke Patients With Cerebral Hypoperfusion" and "Silent Infarcts, White Matter Integrity, and Oxygen Metabolic Stress in Young Adults With and …
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On Episode 19 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the August 2022 issue of Stroke: "Direct to Angiosuite Versus Conventional Imaging in Suspected Large Vessel Occlusion" and "Recurrent Ischemic Stroke and Bleeding in Patients With AF Who Suffered an Acute Stroke While on Treatment With NOACs." She also i…
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On Episode 18 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the July 2022 issue of Stroke: "Impact of Shunting Practice Patterns During Carotid Endarterectomy for Symptomatic Carotid Stenosis" and "Socioeconomic Inequalities in Reperfusion Therapy for Acute Ischemic Stroke." She also interviews Dr. Magdy Selim abo…
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On Episode 17 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the June 2022 issue of Stroke: "Vitamin D Enhances Hematoma Clearance and Neurologic Recovery in Intracerebral Hemorrhage" and "Acute Ischemic Stroke, Depressed Left Ventricular Ejection Fraction, and Sinus Rhythm: Prevalence and Practice Patterns." She a…
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On Episode 16 of the Stroke Alert Podcast, Dr. Negar Asdaghi highlights two articles from the May issue of Stroke: "Number of Affected Relatives, Age, Smoking, and Hypertension Prediction Score for Intracranial Aneurysms in Persons With a Family History for Subarachnoid Hemorrhage" and "Endovascular Treatment for Acute Ischemic Stroke With or Witho…
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On Episode 15 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the April 2022 issue of Stroke: "Kawasaki Disease May Increase the Risk of Subsequent Cerebrovascular Disease" and "Effect of Moderate and Severe Persistent Hyperglycemia on Outcomes in Patients With Intracerebral Hemorrhage." She also interviews Dr. Fran…
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On Episode 14 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the March 2022 issue of Stroke: "Natural Course of Cerebral Cavernous Malformations in Children" and "Direct Oral Anticoagulants Versus Warfarin in Cerebral Venous Thrombosis (ACTION-CVT)." She also interviews Dr. Mohammad Anadani about his article "Magni…
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On Episode 13 of the Stroke Alert Podcast, host Dr. Negar Asdaghi highlights two articles from the February 2022 issue of Stroke: "Cannabis Use and Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage" and "Infertility, Miscarriage, Stillbirth, and the Risk of Stroke Among Women: A Systematic Review and Meta-Analysis." She also interv…
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