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Big Ideas Lab

Mission.org

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Your exploration inside Lawrence Livermore National Laboratory. Hear untold stories, meet boundary-pushing pioneers and get unparalleled access to groundbreaking science and technology. From national security challenges to computing revolutions, discover the innovations that are shaping tomorrow, today.
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LEVITY

Peter Ottsjö

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LEVITY is a podcast offering high-quality, science-informed editorial content focused on aging science and radical life extension. This includes discussions on lifestyle, biotechnology, ethical considerations of life extension, healthcare innovations, research breakthroughs and the role artificial intelligence might play. Our mission is to explore and communicate the scientific and societal pathways toward solving aging. Hosted on Acast. See acast.com/privacy for more information.
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Before We Die

Ariel Nachman & Joey Brenneman

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Before We Die follows the stories of the brave, audacious, and stubbornly persistent problem-solving gizmologists from the Med-Tech world. Join us as top doctors, scientists, bio-designers, and entrepreneurs share their stories of unimaginable successes and heartbreaking failures as they strive to bring their life-saving technology and diagnostic innovations to the patients who need them the most. The Med-Tech industry is booming, but the obstacles and delays are an endless challenge. Can he ...
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The Straight and Marrow

Yvonne and Alex - Bone Marrow Transplant Specialist Nurses

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A show that discusses all things Allogeneic bone marrow transplant. From pre transplant considerations to survivorship using experiences of health care professionals patients & carers with current evidence to keep it straight. The Straight and Marrow podcast is sponsored by ARROW, the Bone Marrow Transplant Foundation.
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Founder Storiez

ephraim yarmak

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The purpose of "FounderStoriez Channel" is to interview Entrepreneurs from around the world to share their story, experience, and wisdom with you so you can learn from them and be inspired.
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Data in Biotech is a fortnightly podcast exploring how companies leverage data to drive innovation in life sciences. Every two weeks, Ross Katz, Principal and Data Science Lead at CorrDyn, sits down with an expert from the world of biotechnology to understand how they use data science to solve technical challenges, streamline operations, and further innovation in their business. You can learn more about CorrDyn - an enterprise data specialist that enables excellent companies to make smarter ...
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Work Talk Podcast

John Salangsang

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Enjoy, learn & be inspired by the stories of the people in the Bay Area - what they do for work, what they know & who they are. Host, John Salangsang, is a college career counselor, job developer & instructor. Instagram.com/worktalkpodcast Twitter.com/worktalkpodcast Facebook.com/worktalkpodcast
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This podcast focuses on interviewing current Product Manager in tech regarding their unique background and experiences with the goal to answer the question “what does it take to become a PM”
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Spit It Out

Avi Robbins

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Have you ever wondered what you can learn about yourself from your Saliva? Are you already an expert in Saliva Diagnostics? Or are you maybe just interested in cool science? Every month Spit it Out will bring you engaging discussions with thought leaders from academia and industry. Through these dialogues, you’ll find out everything from what’s in your saliva to why it’s a good indicator of your overall health. Join us on our mission to make the world safer, healthier and more productive as ...
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We think that death is bad, but why exactly is it bad? We cannot suffer when we do not exist, so why would it be bad? In this episode we have a long, deep conversation with Professor Travis Timmerman, whose philosophical work delves deeply into the nature and ethics of death. An Associate Professor at Seton Hall University, Professor Timmerman has …
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What if scientists could use the peculiar world of quantum mechanics to design solutions once thought impossible - changing how we build, heal, and communicate? At Lawrence Livermore National Laboratory, researchers are developing quantum systems that could help us do just that. These machines think differently, tapping into the strange rules of qu…
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In this episode of Data in Biotech, host Ross Katz sits down with Scott Lipnick, Co-Founder and President of Etiome, to explore how preemptive medicine is changing the way biotech approaches therapeutic modeling and intervention. Discover how Etiome’s recently launched, AI-driven platform is built to detect disease earlier, identify precise biomark…
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Dr Katherine Cummins (Haematologist at the Peter MacCallum Cancer Centre and The Royal Melbourne Hospital with a focus on clinical translation of CAR T-cells and Allogeneic Stem Cell Transplantation) joins Alex and Hannah to discuss the long term complications post CAR T, focusing on infections. Katherine discusses the impact of lymphodepleting che…
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There were two reasons why Dr. Valter Longo was featured so prominently in my longevity book Evigt Ung (2022). First, if you had to name a single scientific thread running through the history of longevity research, calorie restriction is hard to beat. And few have done more to modernize and translate that insight into real-world practice than Longo…
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Artificial intelligence is transforming how science is conducted at Lawrence Livermore National Laboratory. From accelerating drug discovery to optimizing complex experiments, AI is helping researchers work faster, smarter and with greater precision. Today we’ll explore how scientists are using Cognitive Simulation - an AI-driven approach that comb…
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In this episode of Data in Biotech, host Ross Katz speaks with Patrick Torbey, CEO and Co-Founder of Neoplants, about using genetic engineering and microbiome innovation to tackle indoor air pollution. Patrick explains how Neoplants is turning everyday houseplants into powerful air purifiers using synthetic biology, offering insights into VOC degra…
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Three top-tier rising VCs – Jordan Siegel (RedPoint), James Green (CRV), and Morgan Gerlak (TCV) – pull back the curtain on venture capital. In this candid conversation, these friends and competitors share their journey from career pivots and childhood lessons to competitive deal wins and investment philosophies. Discover how they evaluate founders…
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Nicole O'Leary - an experienced CAR-T nurse practitioner - discusses the importance of the role of the carer. CAR T therapy is not a solo journey and in this episode, we shine a light on the unsung heroes: the carers. From managing medications and monitoring for side effects to providing emotional support through the highs and lows, carers play a c…
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This is our first — and probably our last — episode where the guest has brought with him an actual punch card and proceeds to explain why it is, in fact, caca (which is Spanish for 💩, by the way). Welcome to the wild world of José Cordeiro. Stick around and you might hear anecdotes about Robert Kennedy Jr. in Memphis 🎸, late-night karaoke sessions …
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From fusion experiments to cancer-fighting tech, the Jupiter Laser Facility is where bold ideas meet billion-watt lasers. In this episode, we go inside the lab where students and scientists alike get hands-on with some of the most powerful laser systems on Earth - turning science fiction into real-world breakthroughs, one laser shot at a time. -- B…
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Phage therapy is stepping into the spotlight as antibiotic resistance rises - and Jessica Sacher is helping lead the charge. In this episode, Ross Katz speaks with Jessica, Co-Founder of Phage Directory and Staff Scientist at Stanford, about sourcing phages, operationalizing therapy, and predicting efficacy through data. This conversation explores …
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Dr Valeriya Kuznetsova, a neuropsychologist, joins the Straight and Marrow team to discuss the neurological side effects of CAR T cell therapy, including ICANS (immune effector cell-associated neurotoxicity syndrome). From confusion and seizures to subtle cognitive changes, we explore how these toxicities manifest, why they occur, and what can be d…
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Lately, there's been growing pushback against the idea that AI will transform geroscience in the short term. When Nobel laureate Demis Hassabis told 60 Minutes that AI could help cure every disease within 5–10 years, many in the longevity and biotech communities scoffed. Leading aging biologists called it wishful thinking - or outright fantasy. The…
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CAR T-cell therapy is revolutionising cancer treatment, but it comes with unique side effects that every patient and caregiver should understand. In this episode, Dr Hamish Scott joins Alex and Hannah to break down the most common side effects, including cytokine release syndrome (CRS) and neurological toxicities, explaining how they present, how t…
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How do you drug the undruggable? In this episode of Data in Biotech, Ross Katz sits down with Will Fondrie, Head of Data Science and Engineering at Talus Bio, to explore how machine learning, mass spectrometry, and innovative computational models are transforming drug discovery. Learn how Talus Bio is targeting transcription factors—once considered…
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In this episode, we speak with Yair Kuznitsov, CEO and co-founder of Anecdotes. Yair recently led the company through a successful Series B funding round, securing a total of $55 million. Yair provides fascinating insights into the strategic decision to extend Series B rather than rushing to Series C and how Anecdotes is positioned to disrupt the G…
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Peter Fedichev is a visionary scientist, biotech entrepreneur, and physicist at the forefront of longevity research. With a background in theoretical physics, he has seamlessly merged cutting-edge science with real-world applications, making groundbreaking contributions to the fields of aging, biotechnology, and artificial intelligence in healthcar…
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In this episode of the Data and Biotech Podcast, host Ross Katz sits down with Dr. Jonathan Usuka to discuss Usuka’s extensive background in bioinformatics and genomics, leading to his current role as CEO of Sapient. The conversation dives into the importance of deep molecular characterization of diseases, the role of proteomics and metabolomics in…
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Before a laser fires or a rocket launches, machinists make the mission possible. This episode explores the world of machining at Lawrence Livermore National Laboratory—where skilled craftspeople transform raw materials into components for fusion research, national security, and space exploration. From time-tested manual tools to advanced digital ma…
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In this episode of LEVITY, we speak with Laurence Ion, a tech entrepreneur whose experience with a rare genetic disease led him to tackle one of humanity's greatest challenges: aging. Starting as a shy coder who 'couldn't talk to strangers,' Laurence has become a movement leader pioneering a bold new approach: creating specialized cities where exte…
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In the vast silence of space, security is anything but quiet. At Lawrence Livermore National Laboratory, cutting-edge science and strategic defense converge to protect the satellites we rely on—guarding them from cyber threats, kinetic attacks, and space debris. As the risks above grow more complex, we’ll uncover the evolving dangers and the invisi…
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In this powerful episode, Tomer Targin CEO of Yotpo, shares his extraordinary journey of surviving stage 4 lymphoma twice while building a successful company. Tomer reveals how cancer transformed his approach to leadership, family, and life itself. Through meditation, gratitude, and unwavering positivity, he turned devastating diagnoses into fuel f…
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How can AI improve clinical trials and accelerate drug development? In this episode of Data in Biotech, Ross Katz sits down with Patrick Leung, CTO of Faro Health, to explore how AI-driven tools are reshaping clinical trial design. Patrick shares insights into document generation, patient burden analysis, and AI governance in biotech. Learn how Far…
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Today we’ll explore how technologies developed at Lawrence Livermore National Laboratory make their way from the Lab into industry — impacting lives every day, in ways that might surprise you. We’ll explore how scientific breakthroughs like high-peak-power laser peening, 3D metal printing, and more spotlight LLNL’s Innovation and Partnerships Offic…
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"The biggest risk isn't failing—it's not pushing yourself far enough." — Gil, CEO of Orca Security In this episode, we dive deep with Gil Geron, CEO & co-founder of Orca Security. With over $600M in funding and a unicorn valuation, Gil reveals the mindset that's disrupting the cloud security landscape. This isn't your typical success story. Gil ope…
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We have another amazing guest for this episode: Anders Sandberg is a visionary philosopher, futurist, and transhumanist thinker whose work pushes the boundaries of human potential and the future of intelligence. As a senior research fellow at Oxford University’s Future of Humanity Institute until its closing in 2024 Sandberg explores everything fro…
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What if we could harness the same energy that powers the stars to fuel our world? Scientists at Lawrence Livermore National Laboratory are working towards turning this vision into reality. In this episode, we explore how fusion works, why it’s fundamentally different from today’s nuclear energy, and how the groundbreaking achievement of ignition at…
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In this episode of Data In Biotech, Ross Katz interviews Naren Tallapragada, CEO and Co-founder of Tessel Bio, about his background in electrical engineering and physics and how personal circumstances led to him pivoting his focus to enter biotech and start Tessel Bio. Naren breaks down Tessel Bio’s unique approach to drug discovery, which involves…
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Lawrence Livermore National Laboratory is celebrated for its groundbreaking science - from Fusion Ignition to safeguarding the nuclear stockpile. But there’s another story - grounded in community, connection, and a deep culture of giving. In this episode, we’ll explore how the same passion that drives scientific discovery fuels the Lab’s commitment…
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In this in-depth conversation, Dr. Aubrey de Grey discusses his Robust Mouse Rejuvenation (RMR) studies at the LEV Foundation and why he believes we're close to achieving the crucial RMR milestone within just three years - a breakthrough that could transform aging research forever. You'll also hear about: His predictions for reaching Longevity Esca…
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For centuries, drug discovery was a slow, trial-and-error process—sometimes taking decades to develop life-saving treatments. But what if we could speed up that timeline? At Lawrence Livermore National Laboratory, scientists are using supercomputing, machine learning, and AI to revolutionize how new medicines are found, tested, and developed. In th…
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Shae Disney - an expert Apheresis nurse - talks to Hannah and Alex about what to expect when your cells are being collected, from vein assessments to buffy coat and citrate toxicity as she maps out the journey of the cells from collection to infusion.By Yvonne and Alex - Bone Marrow Transplant Specialist Nurses
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In this episode of the Data and Biotech Podcast, host Ross Katz sits down with Alexander Junge, Co-Founder and CTO of amass, to break down how AI is reshaping scientific research in life sciences. Alex walks us through how his platform is creating professional tools for researchers, biotech companies, and venture firms to navigate the (rapidly!) gr…
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Inside the National Ignition Facility, 192 laser beams push the limits of science and technology, supporting critical national security and scientific research. But the extreme energy takes a toll, leaving tiny cracks and damage on the system’s delicate optics. Instead of replacing these costly components, scientists at Lawrence Livermore National …
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Jamie Justice takes us inside the $101M XPRIZE Healthspan competition - one of the world's largest efforts to develop therapeutics that could reverse aging. As Executive Vice President of XPRIZE Healthspan, Jamie reveals how teams must demonstrate they can restore muscle, cognitive, and immune function in older adults within just one year. The stak…
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Asteroids have reshaped Earth before—and scientists know another impact is inevitable. When traditional deflection methods won’t work, what’s the last resort? At Lawrence Livermore National Laboratory, experts are exploring nuclear deflection: using nuclear energy to alter an asteroid’s path or break it apart before impact. But how does it work, wh…
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In this episode of Data in Biotech, Ross sits down with Dipen Sangurdekar, VP of Data Sciences at KSQ Therapeutics, to discuss the role of data-driven approaches in therapeutic design and development. The conversation explores the intersection of computational biology, machine learning, and bioinformatics in advancing personalized medicine and impr…
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In this powerful episode of Founder's Stories, Bruce, Managing Director of Blumberg Capital, takes us through his remarkable journey in venture capital and shares deeply personal insights about life, loss, and leadership. From humble beginnings to managing over a billion dollars in assets, Bruce's story is a testament to the power of perseverance, …
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In 2013, a house-sized asteroid exploded over Chelyabinsk, Russia, with the force of 30 atomic bombs. A century earlier, an asteroid impact flattened 830 square miles of Siberian forest. And while Hollywood loves to dramatize asteroid threats, the real work of planetary defense isn’t happening in action movies—it’s happening in research labs. At La…
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Harnessing Immunity: The CAR T Story is your guide to one of the most ground breaking cancer treatments of our time. This podcast season unpacks how CAR-T therapy is revolutionizing immunotherapy, giving T-cells the power to seek and destroy cancer like never before. From the science behind it to real patient experiences, expert insights, and the l…
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A pediatric cardiac surgeon turned longevity pioneer, Dr. David Luu shares his journey from humanitarian medical missions to building a global network of physicians focused on prevention. Learn about critical health markers your doctor might be missing, how AI is transforming healthcare, the truth about longevity interventions, and why the future b…
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How do you maintain a facility built to achieve the impossible? In this episode, we explore the National Ignition Facility Sustainment Project—an undertaking to ensure that the world’s most energetic laser continues to deliver on its mission. Discover how scientists at the National Ignition Facility keep this technological marvel running, overcomin…
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This week on Data in Biotech, we welcome Timothy Jenkins, the Head of Data Science and Associate Professor at DTU Bioengineering, a leading scientific community dedicated to advancing areas of biotechnology, food technology, and health through innovative teaching and research. Timothy starts the conversation by walking us through his background and…
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The ground beneath us is always moving—but what can it reveal about our future? At Lawrence Livermore National Laboratory, seismic monitoring has evolved into a cornerstone of national security and disaster preparedness. From detecting nuclear tests halfway across the globe to simulating the devastating effects of earthquakes before they strike, th…
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When it comes to skin/cutaneous GVHD, it takes more than thick skin to face the challenges. In this episode, we uncover the layers of this condition—its causes, treatments, and the impact on daily life. With insights from medical experts with a wealth of experience, we peel back the complexities to help you navigate life with skin GVHD, one step at…
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Meet Aleksandr Yampolskiy, the founder and CEO of Security Scorecard, whose journey embodies the American dream. Arriving from Moscow at 14 without speaking English, Aleksandr transformed early hardships into fuel for success, building a cybersecurity company now valued at $1 billion with over $100M in annual revenue. In this episode, Aleksandr ope…
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