AudioHelicase, the podcast of Whitehead Institute: Unwinding the science and the people behind some of the Institute’s most exciting discoveries. Whitehead Institute is a world-renowned non-profit research institution dedicated to improving human health through basic biomedical research. By cultivating a deeply collaborative culture and enabling the pursuit of bold, creative inquiry, Whitehead fosters paradigm-shifting scientific achievement. For more than 30 years, Whitehead faculty have de ...
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AudioHelicase Podcasts
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AudioHelicase Special: When cells are in their element
12:23
12:23
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12:23In this episode of AudioHelicase, we sit down with four Whitehead Institute researchers who are gaining unique insights into biological processes—from regeneration, organ function, and immune response to embryonic development—by studying them within the rich context of their natural environment. Credits: Interviews, production, and hosting by Shafa…
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AudioHelicase Special: How foundational research takes medicines from lab to shelf
21:50
21:50
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21:50In this episode of AudioHelicase, we sit down with three Whitehead Institute researchers driving breakthroughs in disease treatment. Join us as we explore some of the toughest challenges they’re overcoming to move transformative therapies from lab bench to your medicine cabinet. Credits: Interviews, production, and hosting by Shafaq Zia. Music and …
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AudioHelicase Special: Getting a handle on hibernation
12:27
12:27
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12:27Whitehead Institute Member Siniša Hrvatin discusses his research on the neuroscience of hibernation.By AudioHelicase
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AudioHelicase Special: RNA in health and disease
17:57
17:57
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17:57Whitehead Institute researchers Silvi Rouskin, Ankur Jain, and David Bartel discuss how their RNA research connects to health and disease, including viral infections and neurodegeneration. This podcast is part of a multimedia series on RNA.By AudioHelicase
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In this special episode of AudioHelicase, we talk to three researchers about the cells in our bodies that can regenerate – and those that can’t. We ask, why can some cells no longer renew themselves? And, importantly, can we change that? This podcast is part of our multimedia series, Cells Over Time.…
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AudioHelicase Special: How researchers at Whitehead Institute are building a more sustainable future
18:33
18:33
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18:33Making our world more sustainable to preserve it for future generations will take not just one but many solutions. Researchers at Whitehead Institute are exploring how the natural world could teach us how to improve the sustainability of how we produce food, how we make medicines, how we make products more durable, and potentially how we remove car…
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Whitehead Institute’s Silvi Rouskin on solving the structure of the coronavirus genome
17:26
17:26
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17:26In this episode of AudioHelicase Podcast, Whitehead Fellow Silvi Rouskin discusses her research on solving the structure of the novel coronavirus’s RNA genome, with the goal of revealing weak points in the virus’s gene regulation that new drugs could potentially target. Music: “Versailles” by Pierce Murphy (CC-BY 4.0). Produced by Conor Gearin.…
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Whitehead Institute’s Olivia Corradin on a New Way to Probe Disease Genetics
25:12
25:12
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25:12On this episode of AudioHelicase podcast, Whitehead Fellow Olivia Corradin talked about investigating the genetic underpinnings of diseases through a new technique she developed, the outside variant approach. Applying the method to study the autoimmune disease multiple sclerosis (MS), Corradin and colleagues identified a role for a cell type in the…
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Whitehead’s Jing-Ke Weng on COVID-19 treatments taking root in plant science
7:57
7:57
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7:57Plants have been used as medicine for thousands of years; could they contribute to a solution to the COVID-19 pandemic? This is what Whitehead Institute Member Jing-Ke-Weng set out to address in a new paper, published May 20 in the journal Molecular Plant. We talked to Weng about an herbal treatment being used to treat COVID-19 in China derived fro…
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AudioHelicase Special: The Conductors of the Cell’s Symphony
21:23
21:23
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21:23In this special episode of AudioHelicase podcast, we’re taking a look at how our researchers are identifying the key players that help conduct the cell’s symphony — the proteins and molecules that direct many other parts of the cell on when and how to do their jobs. The episode features highlights from interviews with Whitehead Institute Members Da…
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Whitehead Institute’s Pulin Li on creating multicellular patterns in a Petri dish
17:27
17:27
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17:27By AudioHelicase
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Whitehead Institute’s Ankur Jain on RNA clumps and the neurodegenerative diseases they are associated with
12:11
12:11
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12:11In this episode of AudioHelicase, Whitehead Institute Member Ankur Jain discusses how RNA can clump in cells and the diseases, such as Huntington’s and amyotrophic lateral sclerosis (ALS), that are associated with these aggregations.By AudioHelicase
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Whitehead’s Iain Cheeseman discusses cell division and what can happen when it goes wrong
12:44
12:44
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12:44In this episode of AudioHelicase, Whitehead Institute Member Iain Cheeseman discusses how his work on the kinetochore provides a window into cell division and what happens when this vital cellular function goes awry.By AudioHelicase
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Whitehead’s Mary Gehring discusses how gene regulation can be passed from one generation to the next
12:31
12:31
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12:31In this episode of AudioHelicase, Whitehead Institute Member Mary Gehring discusses how her research on the plant Arabidopsis thaliana reveals how gene regulation can be passed from one generation to the next.By AudioHelicase
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Whitehead’s Robert Weinberg on cancer research’s past, present, and future
20:20
20:20
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20:20From his discovery of the first oncogene and tumor suppressor, to his work revealing critical aspects of the mutational basis of cancer, and more recently its metastatic behavior, Whitehead Founding Member Robert Weinberg’s work has been foundational in our understanding of cancer biology.By AudioHelicase
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Whitehead’s Sebastian Lourido on Toxoplasma, malaria parasites, and global health
15:47
15:47
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15:47Whitehead Member Sebastian Lourido studies a group of parasites called the Apicomplexa. These single-celled organisms are among the most common pathogens and are capable of causing devastating diseases in humans and animals, including toxoplasmosis, malaria, and infant diarrhea. Lourido’s laboratory is investigating in particular how the Apicomplex…
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NASA’s Kathleen “Kate” Rubins on her journey from studying pox viruses to sequencing DNA in space
16:18
16:18
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16:18NASA Astronaut and Former Whitehead Fellow Kathleen “Kate” Rubins sits down with Whitehead’s Director David Page to discuss her journey from studying pox viruses to sequencing DNA in space.By Whitehead Institute
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Whitehead’s David Sabatini discusses mTOR, a protein connecting metabolism, nutrition, and disease
10:34
10:34
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10:34As a graduate student, Whitehead Member David Sabatini identified mTOR, the keystone molecule in a cellular pathway connecting nutrition, metabolism, and aging. In this episode, he discusses how the molecule was first discovered and what his lab is currently working on, including mTOR’s role in cancer, growth, and metabolism.…
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