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ASBMB AudioPhiles is a monthly 'best of' summary which features research highlights from ASBMB journals. Our objective for this series of podcasts is to spotlight articles published in the Journal of Biological Chemistry, as well as other news of interest to biochemists and JBC readers. These include announcements, highlights of JBC Papers of the Week, JBC Classics, JBC Reflections, and JBC Mini Reviews. In the future, we will also be highlighting articles from the Journal of Lipid Research ...
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The first growth factors identified and studied during the early 1970s were Epidermal Growth Factor (EGF) and Nerve Growth Factor (NGF). It was soon demonstrated that EGF and NGF mediate their cellular and physiological effects by binding to specific cell membrane receptors: the EGF receptor (EGFR) and the NGF receptor (NGFR), respectively. The mec…
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The joy of teaching lies not only in helping students surpass their own expectations but in the collaborative process that makes learning a shared journey. In my approach, fostering a love for science and learning happens through meaningful collaboration—with students, colleagues, and the broader academic community. I believe that when we embrace c…
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The study of DNA damage has broad relevance to human pathophysiology with its involvement in birth defects, cancer, premature aging syndromes, and certain neurologic disorders. Single strand breaks (SSBs) are among the most common form of endogenous DNA damage. Here we will describe mechanisms by which SSBs threaten genome integrity in mitotic and …
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Science is not performed in a vacuum, and scientists do not make strides without other who have helped them along the way. Throughout my career, I have been fortunate to have had many mentors who have been instrumental in my scientific journey. Now with a career in academia, I have worked hard to improve academia for scientists at all levels, espec…
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A multitude of hydrophobic lipids are present within the cell. Their distribution between the aqueous milieu of the cytosol and amphipathic membranes, and between different organellar membranes, is remarkably variant. In addition to their direct involvement as substrates and intermediates for energy storage and utilization, lipids play key roles in…
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Background: Metabolic dysfunction-associated steatotic liver disease (MASLD) is the fastest-growing etiology of hepatocellular carcinoma (HCC). This work identifies novel gene and lipid associations in human MASLD-driven HCC that may be exploited for therapeutic benefit. Methods: Human HCC tumor (n=8) and adjacent non-tumor samples (n=8) were obtai…
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Keynote presented by Rohit V. Pappu, Washington University in St. Louis, recipient of the 2025 ASBMB DeLano Award for Computational Biosciences.The ASBMB DeLano Award for Computational Biosciences is given to a scientist for accessible and innovative developments or applications of computation to enhance research in the life sciences at the molecul…
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My laboratory has made major contributions to our understanding of non-canonical functions for protein kinases by discovering diverse and unanticipated biochemical activities that are performed by this protein superfamily. Protein kinases have been studied for decades and play important roles in many physiological and pathological processes. The te…
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Success in poker requires taking risks based on incomplete information, reassessing as new information emerges, perseverance in the face of adversity, and a healthy dose of luck. The same is true in scientific research. I will speak to how persistence and serendipity helped define my career and why understanding poker fundamentals can up your scien…
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The rationale, design, and mechanism of GABA aminotransferase and ornithine aminotransferase inactivators will be presented as well as in vitro and in vivo efficacy and pharmacokinetic results, toxicology studies, and a clinical trial with one of the inactivators.By ASBMB
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The Alice and C.C. Wang Award in Molecular Parasitology recognizes established investigators who are making seminal contributions to the field of molecular parasitology. David S. Roos is a professor of biology at the University of Pennsylvania. His laboratory studies the biochemistry, cell biology, molecular genetics, genomics and evolutionary biol…
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The Walter A. Shaw Young Investigator Award in Lipid Research recognizes outstanding research contributions in the area of lipids by a young investigator. Judith Simcox is an assistant professor of biochemistry at the University of Wisconsin–Madison. Her lab studies plasma lipids that regulate metabolic disease and explores how these lipids functio…
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*The award lecture and its accompanying slides are also available to watch here: https://youtu.be/AmP_8FG0dDU.The Earl and Thressa Stadtman Distinguished Scientist Award is awarded to a distinguished scientist for their outstanding achievement in basic research in the fields encompassed by the ASBMB. Bruce Stillman is president and chief executive …
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The Avanti Award in Lipids recognizes outstanding research contributions in the area of lipids. Tamás Balla is a senior investigator at the Eunice Kennedy Shriver National Institute of Child Health and Human Development. He leads the Section on Molecular Signal Transduction, which studies the spatial and temporal organization of cellular membrane l…
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*The award lecture and its accompanying slides are also available to watch here: https://youtu.be/h8-_Kyqyoq0.The ASBMB William C. Rose Award for Exemplary Contributions to Education recognizes an individual who demonstrates an exceptional contribution to the teaching of biochemistry and molecular biology. Peter J. Kennelly is a professor at the Vi…
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*The award lecture and its accompanying slides are also available to watch here: https://youtu.be/XmjU5aXYtjU.The Ruth Kirschstein Diversity in Science Award honors an outstanding scientist who has shown a sustained commitment to breaking down local and/or systemic barriers against scientists and students from historically marginalized or excluded …
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The ASBMB Mildred Cohn Young Investigator Award recognizes outstanding research contributions to biochemistry and molecular biology. Nozomi Ando is an associate professor at Cornell University’s chemistry and chemical biology department. Her lab works on new structural biology methods, such as diffuse scattering analysis of X-ray diffraction images…
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*The award lecture and its accompanying slides are also available to watch here: https://youtu.be/-SEHPd6UwCE.The DeLano Award for Computational Biosciences is given to a scientist for the most accessible and innovative development or application of computer technology to enhance research in the life sciences at the molecular level. Ruppin is a com…
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*The award lecture and its accompanying slides are also available to watch here: https://youtu.be/fM6aPNO8MxY.The Herbert Tabor Research Award is given for outstanding, innovative accomplishments in biological chemistry and molecular biology and contributions to the community of scientists. Margaret Phillips is chair of the biochemistry department …
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*The award lecture and its accompanying slides are also available to watch here: https://youtu.be/brIHwjoGqRc.The Bert & Natalie Vallee Award in Biomedical Science is awarded to an established scientist for outstanding accomplishments in basic biomedical research. Hao Wu is a professor at Harvard Medical School. Wu’s lab uses cryo-electron microsco…
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John Boothroyd, a professor and administrator at Stanford University, won the 2022 Alice and C. C. Wang Award in Molecular Parasitology, which recognizes established investigators who are making seminal contributions to the field of molecular parasitology. Boothroyd leads a lab that studies the pathogenesis of parasitic infections, in particular To…
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Tatyana Sharpee, a professor and chair at the Salk Institute for Biological Studies, won the 2022 DeLano Award for Computational Biosciences, which recognizes the most accessible and innovative development or application of computer technology to enhance research in the life sciences at the molecular level. Sharpee’s lab studies how the brain and o…
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Susan S. Taylor, a distinguished professor at the University of California, San Diego, won the 2022 Herbert Tabor Research Award, which is given for excellence in biological chemistry and molecular biology and contributions to the community of scientists. Taylor has done pioneering structural studies of protein kinase A, revealing fundamental theme…
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Tracy Johnson, dean of life sciences and a professor at UCLA and a Howard Hughes Medical Institute professor, won the 2022 Ruth Kirschstein Diversity in Science Award, which the ASBMB Minority Affairs Committee gives to an outstanding scientist who has shown a strong commitment to the encouragement of underrepresented minorities to enter the scient…
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Elaine Fuchs, a professor at the Rockefeller University and a Howard Hughes Medical Institute investigator, won the 2022 Bert and Natalie Vallee Award in Biomedical Science. Established in 2012 by the Bert and Natalie Kuggie Vallee Foundation, this award recognizes outstanding accomplishments in basic biomedical research. She presented her award le…
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J. Martin Bollinger Jr., a professor at the Pennsylvania State University, won the 2022 William C. Rose Award, which recognizes outstanding contributions to biochemical and molecular biological research and a demonstrated commitment to the training of younger scientists. He presented his award lecture, "Progress Toward Understanding Protein Control…
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Alex Toker, winner of the 2022 Avanti Award in Lipids, which recognizes outstanding lipid research contributions, presented his lecture, "PI 3-Kinase signaling: A journey in three AKTs," on Monday, April 4, at the 2022 ASBMB Annual Meeting, held in conjunction with Experimental Biology, in Philadelphia. Learn more about his work: https://www.asbmb.…
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Janet Smith, a professor at the University of Michigan Medical School, associate director of the UM Life Sciences Institute and scientific director of the GM/CA beamlines at the Argonne synchrotron, won the 2022 Mildred Cohn Award in Biological Chemistry, which honors scientists at all stages of their careers who have made substantial advances in u…
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Kathleen Collins, winner of the 2022 Earl and Thressa Stadtman Distinguished Scientist Award, presented her lecture, "Telomerase holoenzymes" on Monday, April 4, at the 2022 ASBMB Annual Meeting, held in conjunction with Experimental Biology, in Philadelphia. Learn more about her work: https://www.asbmb.org/asbmb-today/people/122121/telomerase-stud…
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Joseph Provost, winner of the 2022 ASBMB Exemplary Contributions to Education Award, presented his lecture, "It's all about the students," on Sunday, April 3, at the 2022 ASBMB Annual Meeting, held in conjunction with Experimental Biology, in Philadelphia. Learn more about his work: https://www.asbmb.org/asbmb-today/people/121421/provost-makes-chem…
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Michael Airola, winner of the 2022 Walter A. Shaw Young Investigator Award in Lipid Research, presented his lecture, "Snapshots of lipid synthesis and fat storage" on Sunday, April 3, at the 2022 ASBMB Annual Meeting, held in conjunction with Experimental Biology, in Philadelphia. Learn more about his work: https://www.asbmb.org/asbmb-today/people/…
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Robert V. Farese Jr. and Tobias C. Walther won the 2022 ASBMB–Merck Award, which recognizes outstanding contributions to research in biochemistry and molecular biology. The pair’s joint lab studies lipid homeostasis and storage and neurodegeneration. Farese and Walther are professors at Harvard Medical School and the Harvard T.H. Chan School of Pub…
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Greg G. Wang, a professor at the University of North Carolina School of Medicine and member of the UNC Lineberger Comprehensive Cancer Center, won the 2022 ASBMB Young Investigator Award, which recognizes outstanding research contributions to biochemistry and molecular biology and contributions to the community of scientists. Wang’s lab studies how…
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Apprenticeships offer pathways into biotechnology for a growing number of students. How does the training model work, why are policymakers excited about it, and who wants to be an apprentice? Laurel Oldach, a science writer for the ASBMB, and Sarina Neote, ASBMB's science policy manager, have the story. Read their ASBMB Today article to learn even …
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Host Benjamin Corb interviews the National Institutes of Health's Director of the Center for Scientific Review (CSR) Dr. Noni Byrnes. They discuss how the CSR has moved to an all remote peer review process during the COVID-19 pandemic crisis, and how peer reviewers are adopting to this newer format.Benjamin Corb - @bwcorb on twitterNoni Byrnes (CSR…
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ASBMB Public affairs director Benjamin Corb is joined by the National Science Foundation's Dr. Joanne Tornow. Dr. Tornow is the Assistant Director of the Biological Sciences Division of the NSF. They discuss programs implemented by the NSF to support funded investigators in these trying times, how NSF is handling remote peer review of grants, and t…
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Host Benjamin Corb is joined by Dr. Regina Richards. Dr. Richards is the Director of the Office of Diversity and Inclusion at the University of Colorado School of Medicine. They discuss how preexisting health disparities are felt more acutely during the COVID-19 pandemic, and how scientists, doctors and the community can begin to take steps to over…
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ASBMB Public Affairs Director Benjamin Corb is joined by Christopher Pickett. Pickett is the Director of Rescuing Biomedical Research, a project started by identifying the need to take action to improve the biomedical research workforce and enterprise. RBR is hosting a series over the next several weeks which is aimed at identifying what systemic c…
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In our latest installment, ASBMB Public Affairs Director and host Benjamin Corb speaks with John Arnst, a staff writer for ASBMB Today and Laurel Oldach, a science communicator for ASBMB. Their conversation explored what its like to be a professional science communicator in a time when the public is consuming science news like never before. Benjami…
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